DegronMD

Uniprot ID: Q8IZH2

Source protein: 5'-3' exoribonuclease 1

Source gene: XRN1

Class: DEG_SCF_FBW7_2

Location: 133:138

E3 ligase: FBXW7

DEGRON score: 0.7657

ASA_SCORE: 31.6833

COIL: 0.5113

CONS_SCORE: 0.5305

DSS_SCORE: 0.2755

HELIX: 0.3495

FCONS_SCORE: 1.2903

RIG_SCORE: 0.7771

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D129E	TCGA-AA-A010	COAD	TCGA	ITPGTE	DEG_SCF_FBW7_2	0.2222
p.A141T	TCGA-B5-A3FA	UCEC	TCGA	ITPGTE	DEG_SCF_FBW7_2	0.25
p.A141T	DO52402	UCEC	ICGC	ITPGTE	DEG_SCF_FBW7_2	0.25
p.C132Y	TCGA-J9-A8CN	PRAD	TCGA	ITPGTE	DEG_SCF_FBW7_2	0.3056
p.C132Y	DO219269	PRAD	ICGC	ITPGTE	DEG_SCF_FBW7_2	0.3056
p.E145K	DO217844	BRCA	ICGC	ITPGTE	DEG_SCF_FBW7_2	0.1389
p.D147Y	DO3110	BRCA	ICGC	ITPGTE	DEG_SCF_FBW7_2	0.0833
p.D147Y	DO50420	PRAD	ICGC	ITPGTE	DEG_SCF_FBW7_2	0.0833
p.P135Q	DO228948	LICA	ICGC	ITPGTE	DEG_SCF_FBW7_2	0.7035
p.A141D	DO229018	LICA	ICGC	ITPGTE	DEG_SCF_FBW7_2	0.25
p.P124H	DO229022	LICA	ICGC	ITPGTE	DEG_SCF_FBW7_2	0.0833
p.L130I	DO229032	LICA	ICGC	ITPGTE	DEG_SCF_FBW7_2	0.25
p.G136E	DO50970	LICA	ICGC	ITPGTE	DEG_SCF_FBW7_2	0.6087
p.R138W	DO220911	MELA	ICGC	ITPGTE	DEG_SCF_FBW7_2	0.8634
p.D135Y	DO229232	THCA	ICGC	ITPGTE	DEG_SCF_FBW7_2	0.7325
p.R125Q	DO40884	UCEC	ICGC	ITPGTE	DEG_SCF_FBW7_2	0.1111
p.K148T	SIDM01237	Hepatocellular Carcinoma	GDSC	ITPGTE	DEG_SCF_FBW7_2	0.1667
p.K148T	ACH-001021	Liver Cancer	CCLE	ITPGTE	DEG_SCF_FBW7_2	0.1667
p.K148T	C3A	liver	COSMIC	ITPGTE	DEG_SCF_FBW7_2	0.1667
p.D129Y	SIDM00681	Colorectal Carcinoma	GDSC	ITPGTE	DEG_SCF_FBW7_2	0.2222
p.D129Y	ACH-000252	Colon/Colorectal Cancer	CCLE	ITPGTE	DEG_SCF_FBW7_2	0.2222
p.D129Y	LS-1034	large_intestine	COSMIC	ITPGTE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons