DegronMD

Uniprot ID: Q9H0D6

Source protein: 5'-3' exoribonuclease 2

Source gene: XRN2

Class: DEG_SCF_FBW7_2

Location: 160:165

E3 ligase: FBXW7

DEGRON score: 0.7839

ASA_SCORE: 35.6

COIL: 0.5762

CONS_SCORE: 0.8334

DSS_SCORE: 0.2048

HELIX: 0.3265

FCONS_SCORE: 1.5424

RIG_SCORE: 0.7953

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R154S	TCGA-F5-6814	READ	TCGA	ITPGTE	DEG_SCF_FBW7_2	0.1667
p.A156S	DO21487	LAML	ICGC	ITPGTE	DEG_SCF_FBW7_2	0.2222
p.G164S	DO52243	LIHC	ICGC	ITPGTE	DEG_SCF_FBW7_2	0.6993
p.P170Q	DO47407	SKCM	ICGC	ITPGTE	DEG_SCF_FBW7_2	0.1944
p.L153S	DO40884	UCEC	ICGC	ITPGTE	DEG_SCF_FBW7_2	0.1389
p.R154I	SNU-81	large_intestine	COSMIC	ITPGTE	DEG_SCF_FBW7_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons