DegronMD - Q9H0D6(XRN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P797R	TCGA-CG-5728	STAD	TCGA	RRPVHLD	LIG_APCC_ABBAyCdc20_2	805:811	Mutation rewiring degron network	0.1111
p.G800D	TCGA-D1-A103	UCEC	TCGA	RRPVHLD	LIG_APCC_ABBAyCdc20_2	805:811	Mutation rewiring degron network	0.1944
p.F652L	TCGA-EE-A20C	SKCM	TCGA	LLPFVD	LIG_APCC_ABBA_1	649:654	Mutation altering degron motif	0.6981
p.D811G	TCGA-EO-A22U	UCEC	TCGA	RRPVHLD	LIG_APCC_ABBAyCdc20_2	805:811	Mutation altering degron motif	0.7198
p.R154S	TCGA-F5-6814	READ	TCGA	ITPGTE	DEG_SCF_FBW7_2	160:165	Mutation rewiring degron network	0.1667
p.R659Q	TCGA-FD-A43U	BLCA	TCGA	LLPFVD	LIG_APCC_ABBA_1	649:654	Mutation rewiring degron network	0.1944
p.P798S	DO44045	BLCA	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	805:811	Mutation rewiring degron network	0.1389
p.Q801H	DO222877	COCA	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	805:811	Mutation rewiring degron network	0.2222
p.R819Q	DO52112	HNSC	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	805:811	Mutation rewiring degron network	0.1111
p.A156S	DO21487	LAML	ICGC	ITPGTE	DEG_SCF_FBW7_2	160:165	Mutation rewiring degron network	0.2222
p.K645N	DO229036	LICA	ICGC	LLPFVD	LIG_APCC_ABBA_1	649:654	Mutation rewiring degron network	0.2222
p.A811S	DO229041	LICA	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	805:811	Mutation altering degron motif	0.7588
p.G164S	DO52243	LIHC	ICGC	ITPGTE	DEG_SCF_FBW7_2	160:165	Mutation altering degron motif	0.6993
p.G644E	DO48884	LUAD	ICGC	LLPFVD	LIG_APCC_ABBA_1	649:654	Mutation rewiring degron network	0.1944
p.Q802P	DO48553	PAEN	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	805:811	Mutation rewiring degron network	0.25
p.G641V	DO37543	SKCM	ICGC	LLPFVD	LIG_APCC_ABBA_1	649:654	Mutation blocking ubiquitination signal	0.5556
p.P797S	DO37432	SKCM	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	805:811	Mutation rewiring degron network	0.1111
p.P170Q	DO47407	SKCM	ICGC	ITPGTE	DEG_SCF_FBW7_2	160:165	Mutation rewiring degron network	0.1944
p.W817L	DO38404	STAD	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	805:811	Mutation rewiring degron network	0.1667
p.R819W	DO38711	STAD	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	805:811	Mutation rewiring degron network	0.1111
p.Q803H	DO219773	UCEC	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	805:811	Mutation rewiring degron network	0.2778
p.L153S	DO40884	UCEC	ICGC	ITPGTE	DEG_SCF_FBW7_2	160:165	Mutation rewiring degron network	0.1389
p.F646L	DO43306	UCEC	ICGC	LLPFVD	LIG_APCC_ABBA_1	649:654	Mutation rewiring degron network	0.25
p.V659I	DO42280	UCEC	ICGC	LLPFVD	LIG_APCC_ABBA_1	649:654	Mutation rewiring degron network	0.1944
p.S647Y	DO41488	UCEC	ICGC	LLPFVD	LIG_APCC_ABBA_1	649:654	Mutation rewiring degron network	0.2778
p.S647Y	DO41379	UCEC	ICGC	LLPFVD	LIG_APCC_ABBA_1	649:654	Mutation rewiring degron network	0.2778
p.K641R	SIDM01043	Other Sarcomas	GDSC	LLPFVD	LIG_APCC_ABBA_1	649:654	Mutation blocking ubiquitination signal	0.5556
p.K641R	ACH-000913	Endometrial/Uterine Cancer	CCLE	LLPFVD	LIG_APCC_ABBA_1	649:654	Mutation blocking ubiquitination signal	0.5556
p.K641R	ESS-1	endometrium	COSMIC	LLPFVD	LIG_APCC_ABBA_1	649:654	Mutation blocking ubiquitination signal	0.5556
p.L649P	SIDM00948	Burkitt's Lymphoma	GDSC	LLPFVD	LIG_APCC_ABBA_1	649:654	Mutation altering degron motif	0.7582
p.L649P	ACH-002232	Lymphoma	CCLE	LLPFVD	LIG_APCC_ABBA_1	649:654	Mutation altering degron motif	0.7582
p.L649P	DG-75	haematopoietic and lymphoid tissue	COSMIC	LLPFVD	LIG_APCC_ABBA_1	649:654	Mutation altering degron motif	0.7582
p.R154I	SNU-81	large intestine	COSMIC	ITPGTE	DEG_SCF_FBW7_2	160:165	Mutation rewiring degron network	0.1667

Kaplan plot for XRN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

XRN2

UniProt ID: Q9H0D6

Entrez ID: 22803

Protein name: 5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for XRN2 in