DegronMD

Uniprot ID: Q9H0D6

Source protein: 5'-3' exoribonuclease 2

Source gene: XRN2

Class: LIG_APCC_ABBAyCdc20_2

Location: 805:811

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6777

ASA_SCORE: 95.9857

COIL: 0.7564

CONS_SCORE: 0.2492

DSS_SCORE: 0.457

HELIX: 0.1899

FCONS_SCORE: 0.8785

RIG_SCORE: 0.7717

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P797R	TCGA-CG-5728	STAD	TCGA	RRPVHLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G800D	TCGA-D1-A103	UCEC	TCGA	RRPVHLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D811G	TCGA-EO-A22U	UCEC	TCGA	RRPVHLD	LIG_APCC_ABBAyCdc20_2	0.7198
p.P798S	DO44045	BLCA	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	0.1389
p.Q801H	DO222877	COCA	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R819Q	DO52112	HNSC	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.A811S	DO229041	LICA	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	0.7588
p.Q802P	DO48553	PAEN	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	0.25
p.P797S	DO37432	SKCM	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.W817L	DO38404	STAD	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R819W	DO38711	STAD	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q803H	DO219773	UCEC	ICGC	RRPVHLD	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0D6	5'-3' exoribonuclease 2	LIG_APCC_ABBAyCdc20_2	805:811	RRPVHLD	APC,CDC20,FZR1	0.6777	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons