DegronMD

Uniprot ID: Q9H0D6

Source protein: 5'-3' exoribonuclease 2

Source gene: XRN2

Class: LIG_APCC_ABBA_1

Location: 649:654

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6553

ASA_SCORE: 35.6667

COIL: 0.7

CONS_SCORE: 0.6534

DSS_SCORE: 0.0578

HELIX: 0.019

FCONS_SCORE: 1.3627

RIG_SCORE: 0.9051

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F652L	TCGA-EE-A20C	SKCM	TCGA	LLPFVD	LIG_APCC_ABBA_1	0.6981
p.R659Q	TCGA-FD-A43U	BLCA	TCGA	LLPFVD	LIG_APCC_ABBA_1	0.1944
p.K645N	DO229036	LICA	ICGC	LLPFVD	LIG_APCC_ABBA_1	0.2222
p.G644E	DO48884	LUAD	ICGC	LLPFVD	LIG_APCC_ABBA_1	0.1944
p.G641V	DO37543	SKCM	ICGC	LLPFVD	LIG_APCC_ABBA_1	0.5556
p.F646L	DO43306	UCEC	ICGC	LLPFVD	LIG_APCC_ABBA_1	0.25
p.V659I	DO42280	UCEC	ICGC	LLPFVD	LIG_APCC_ABBA_1	0.1944
p.S647Y	DO41488	UCEC	ICGC	LLPFVD	LIG_APCC_ABBA_1	0.2778
p.S647Y	DO41379	UCEC	ICGC	LLPFVD	LIG_APCC_ABBA_1	0.2778
p.K641R	SIDM01043	Other Sarcomas	GDSC	LLPFVD	LIG_APCC_ABBA_1	0.5556
p.K641R	ACH-000913	Endometrial/Uterine Cancer	CCLE	LLPFVD	LIG_APCC_ABBA_1	0.5556
p.K641R	ESS-1	endometrium	COSMIC	LLPFVD	LIG_APCC_ABBA_1	0.5556
p.L649P	SIDM00948	Burkitt's Lymphoma	GDSC	LLPFVD	LIG_APCC_ABBA_1	0.7582
p.L649P	ACH-002232	Lymphoma	CCLE	LLPFVD	LIG_APCC_ABBA_1	0.7582
p.L649P	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	LLPFVD	LIG_APCC_ABBA_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0D6	5'-3' exoribonuclease 2	LIG_APCC_ABBA_1	649:654	LLPFVD	APC,CDC20,FZR1	0.6553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons