DegronMD - Q7M4L6(SHF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G73R	TCGA-05-4398	LUAD	TCGA	PISSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1389
p.G73R	DO25847	LUAD	ICGC	PISSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1389
p.S65P	TCGA-4Z-AA7M	BLCA	TCGA	PISSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.6752
p.S65P	DO218976	BLCA	ICGC	PISSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.6752
p.Q68H	TCGA-A5-A1OF	UCEC	TCGA	PISSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.2778
p.Q68H	DO42568	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.2778
p.P52L	TCGA-FW-A3R5	SKCM	TCGA	PISSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0556
p.P52L	DO37406	SKCM	ICGC	PISSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0556
p.Q76E	TCGA-IR-A3LA	CESC	TCGA	PISSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0556
p.Q76E	DO44377	CESC	ICGC	PISSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0556
p.S64L	DO230334	COCA	ICGC	PISSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.7667
p.S64L	DO229005	COCA	ICGC	PISSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.7667
p.S64L	DO230659	LAML	ICGC	PISSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.7667
p.S64L	DO231140	LAML	ICGC	PISSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.7667
p.S64L	DO228941	LICA	ICGC	PISSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.7667
p.S67R	DO233144	GACA	ICGC	PISSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.3056
p.L53V	DO50685	ORCA	ICGC	PISSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0833
p.N54K	SIDM00487	Colorectal Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1111
p.N54K	ACH-000963	Colon/Colorectal Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1111
p.N54K	CCK-81	large intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1111
p.H59Q	ACH-001367	Neuroblastoma	CCLE	PISSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.25
p.E62D	MFE-319	endometrium	COSMIC	PISSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.6758

Kaplan plot for SHF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHF

UniProt ID: Q7M4L6

Entrez ID:

Protein name: SH2 domain-containing adapter protein F

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHF in