DegronMD

Uniprot ID: Q7M4L6

Source protein: SH2 domain-containing adapter protein F

Source gene: SHF

Class: DEG_SPOP_SBC_1

Location: 62:66

E3 ligase: SPOP

DEGRON score: 0.9333

ASA_SCORE: 80.78

COIL: 0.9442

CONS_SCORE: 0.3867

DSS_SCORE: 0.6948

HELIX: 0.0192

FCONS_SCORE: 0.9568

RIG_SCORE: 0.5787

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S64L	DO230334	COCA	ICGC	PISSS	DEG_SPOP_SBC_1	0.7667
p.S64L	DO229005	COCA	ICGC	PISSS	DEG_SPOP_SBC_1	0.7667
p.S64L	DO230659	LAML	ICGC	PISSS	DEG_SPOP_SBC_1	0.7667
p.S64L	DO231140	LAML	ICGC	PISSS	DEG_SPOP_SBC_1	0.7667
p.S64L	DO228941	LICA	ICGC	PISSS	DEG_SPOP_SBC_1	0.7667
p.E62D	MFE-319	endometrium	COSMIC	PISSS	DEG_SPOP_SBC_1	0.6758
p.S65P	TCGA-4Z-AA7M	BLCA	TCGA	PISSS	DEG_SPOP_SBC_1	0.6752
p.S65P	DO218976	BLCA	ICGC	PISSS	DEG_SPOP_SBC_1	0.6752
p.S67R	DO233144	GACA	ICGC	PISSS	DEG_SPOP_SBC_1	0.3056
p.Q68H	TCGA-A5-A1OF	UCEC	TCGA	PISSS	DEG_SPOP_SBC_1	0.2778
p.Q68H	DO42568	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	0.2778
p.H59Q	ACH-001367	Neuroblastoma	CCLE	PISSS	DEG_SPOP_SBC_1	0.25
p.G73R	TCGA-05-4398	LUAD	TCGA	PISSS	DEG_SPOP_SBC_1	0.1389
p.G73R	DO25847	LUAD	ICGC	PISSS	DEG_SPOP_SBC_1	0.1389
p.N54K	SIDM00487	Colorectal Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.1111
p.N54K	ACH-000963	Colon/Colorectal Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	0.1111
p.N54K	CCK-81	large_intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	0.1111
p.L53V	DO50685	ORCA	ICGC	PISSS	DEG_SPOP_SBC_1	0.0833
p.P52L	TCGA-FW-A3R5	SKCM	TCGA	PISSS	DEG_SPOP_SBC_1	0.0556
p.P52L	DO37406	SKCM	ICGC	PISSS	DEG_SPOP_SBC_1	0.0556
p.Q76E	TCGA-IR-A3LA	CESC	TCGA	PISSS	DEG_SPOP_SBC_1	0.0556
p.Q76E	DO44377	CESC	ICGC	PISSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 22 of 22 entries

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Drug responses associated with SHF mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PISSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N983	39S ribosomal protein L43, mitochondrial	DEG_SPOP_SBC_1	184:188	PISSS	SPOP	0.8798	More...
Q8IZH2	5'-3' exoribonuclease 1	DEG_SPOP_SBC_1	1684:1688	PISSS	SPOP	0.9961	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1507:1511	PISSS	SPOP	0.9387	More...
Q8TF27	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11	DEG_SPOP_SBC_1	193:197	PISSS	SPOP	0.9254	More...
A6NIR3	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5	DEG_SPOP_SBC_1	354:358	PISSS	SPOP	0.9883	More...
Q5VW22	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6	DEG_SPOP_SBC_1	331:335	PISSS	SPOP	0.9118	More...
Q5VTM2	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9	DEG_SPOP_SBC_1	399:403	PISSS	SPOP	0.9606	More...
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	586:590	PISSS	SPOP	0.963	More...
O15444	C-C motif chemokine 25	DEG_SPOP_SBC_1	132:136	PISSS	SPOP	0.8813	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	314:318	PISSS	SPOP	0.9982	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	931:935	PISSS	SPOP	0.9118	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	532:536	PISSS	SPOP	0.9978	More...
O75030	Microphthalmia-associated transcription factor	DEG_SPOP_SBC_1	47:51	PISSS	SPOP	0.9949	More...
P26367	Paired box protein Pax-6	DEG_SPOP_SBC_1	286:290	PISSS	SPOP	0.8502	More...
Q5VUJ5	Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7	DEG_SPOP_SBC_1	331:335	PISSS	SPOP	0.9817	More...
Q7M4L6	SH2 domain-containing adapter protein F	DEG_SPOP_SBC_1	62:66	PISSS	SPOP	0.9333	More...
O94864	STAGA complex 65 subunit gamma	DEG_SPOP_SBC_1	11:15	PISSS	SPOP	0.9981	More...
Q92908	Transcription factor GATA-6	DEG_SPOP_SBC_1	38:42	PISSS	SPOP	0.7589	More...

Showing 1 to 18 of 18 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PISSS

Degron related mutations and impact score

Drug responses associated with SHF mutations

All proteins holding degron of PISSS