DegronMD

Uniprot ID: Q9ULL0

Source protein: Acrosomal protein KIAA1210

Source gene: KIAA1210

Class: DEG_SPOP_SBC_1

Location: 1507:1511

E3 ligase: SPOP

DEGRON score: 0.9387

ASA_SCORE: 87.7

COIL: 0.93

CONS_SCORE: 0.4812

DSS_SCORE: 0.5236

HELIX: 0.0296

FCONS_SCORE: 1.2626

RIG_SCORE: 0.6085

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1514M	TCGA-44-2655	LUAD	TCGA	PISSS	DEG_SPOP_SBC_1	0.25
p.R1514M	DO23557	LUAD	ICGC	PISSS	DEG_SPOP_SBC_1	0.25
p.S1505T	TCGA-44-5644	LUAD	TCGA	PISSS	DEG_SPOP_SBC_1	0.2778
p.S1505T	DO25153	LUAD	ICGC	PISSS	DEG_SPOP_SBC_1	0.2778
p.S1520I	TCGA-AN-A0FL	BRCA	TCGA	PISSS	DEG_SPOP_SBC_1	0.0833
p.S1520I	DO1836	BRCA	ICGC	PISSS	DEG_SPOP_SBC_1	0.0833
p.R1514S	TCGA-D3-A3CE	SKCM	TCGA	PISSS	DEG_SPOP_SBC_1	0.25
p.R1514S	DO37405	SKCM	ICGC	PISSS	DEG_SPOP_SBC_1	0.25
p.P1507L	TCGA-D3-A8GQ	SKCM	TCGA	PISSS	DEG_SPOP_SBC_1	0.7582
p.P1507L	DO51246	SKCM	ICGC	PISSS	DEG_SPOP_SBC_1	0.7582
p.S1505L	DO225215	BRCA	ICGC	PISSS	DEG_SPOP_SBC_1	0.2778
p.S1505L	DO227836	BRCA	ICGC	PISSS	DEG_SPOP_SBC_1	0.2778
p.S1505L	SIDM00672	Hepatocellular Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.2778
p.S1505L	SIDM00656	Burkitt's Lymphoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.2778
p.S1505L	SIDM00346	Chronic Myelogenous Leukemia	GDSC	PISSS	DEG_SPOP_SBC_1	0.2778
p.S1505L	SIDM00493	Other Solid Cancers	GDSC	PISSS	DEG_SPOP_SBC_1	0.2778
p.S1505L	SIDM00844	Burkitt's Lymphoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.2778
p.S1505L	SIDM00641	Burkitt's Lymphoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.2778
p.G1506D	DO229345	LAML	ICGC	PISSS	DEG_SPOP_SBC_1	0.3056
p.G1506D	SIDM01749	Osteosarcoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.3056
p.T1521I	DO228945	LICA	ICGC	PISSS	DEG_SPOP_SBC_1	0.0556
p.Q1499H	SIDM00534	Colorectal Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.1111
p.Q1499H	ACH-000986	Colon/Colorectal Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	0.1111
p.Q1499H	HT-115	large_intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15444	C-C motif chemokine 25	DEG_SPOP_SBC_1	132:136	PISSS	SPOP	0.8813	More...
O75030	Microphthalmia-associated transcription factor	DEG_SPOP_SBC_1	47:51	PISSS	SPOP	0.9949	More...
O94864	STAGA complex 65 subunit gamma	DEG_SPOP_SBC_1	11:15	PISSS	SPOP	0.9981	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	314:318	PISSS	SPOP	0.9982	More...
P26367	Paired box protein Pax-6	DEG_SPOP_SBC_1	286:290	PISSS	SPOP	0.8502	More...
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	586:590	PISSS	SPOP	0.963	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	931:935	PISSS	SPOP	0.9118	More...
Q8IZH2	5'-3' exoribonuclease 1	DEG_SPOP_SBC_1	1684:1688	PISSS	SPOP	0.9961	More...
Q8N983	39S ribosomal protein L43, mitochondrial	DEG_SPOP_SBC_1	184:188	PISSS	SPOP	0.8798	More...
Q92908	Transcription factor GATA-6	DEG_SPOP_SBC_1	38:42	PISSS	SPOP	0.7589	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	532:536	PISSS	SPOP	0.9978	More...
Q7M4L6	SH2 domain-containing adapter protein F	DEG_SPOP_SBC_1	62:66	PISSS	SPOP	0.9333	More...
A6NIR3	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5	DEG_SPOP_SBC_1	354:358	PISSS	SPOP	0.9883	More...
Q5VTM2	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9	DEG_SPOP_SBC_1	399:403	PISSS	SPOP	0.9606	More...
Q5VUJ5	Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7	DEG_SPOP_SBC_1	331:335	PISSS	SPOP	0.9817	More...
Q5VW22	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6	DEG_SPOP_SBC_1	331:335	PISSS	SPOP	0.9118	More...
Q8TF27	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11	DEG_SPOP_SBC_1	193:197	PISSS	SPOP	0.9254	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1507:1511	PISSS	SPOP	0.9387	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PISSS

Degron related mutations and impact score

Drug responses associated with KIAA1210 mutations

All proteins holding degron of PISSS