DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PISSS
Uniprot ID:
Q5VUJ5
Source protein:
Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7
Source gene:
AGAP7P
Class:
DEG_SPOP_SBC_1
Location:
331:335
E3 ligase:
SPOP
DEGRON score:
0.9817
ASA_SCORE:
66.06
COIL:
0.8274
CONS_SCORE:
0.2592
DSS_SCORE:
0.3307
HELIX:
0.0426
FCONS_SCORE:
0.942
RIG_SCORE:
0.7148
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with AGAP7P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PISSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15444
C-C motif chemokine 25
DEG_SPOP_SBC_1
132:136
PISSS
SPOP
0.8813
More...
O75030
Microphthalmia-associated transcription factor
DEG_SPOP_SBC_1
47:51
PISSS
SPOP
0.9949
More...
O94864
STAGA complex 65 subunit gamma
DEG_SPOP_SBC_1
11:15
PISSS
SPOP
0.9981
More...
O95628
CCR4-NOT transcription complex subunit 4
DEG_SPOP_SBC_1
314:318
PISSS
SPOP
0.9982
More...
P26367
Paired box protein Pax-6
DEG_SPOP_SBC_1
286:290
PISSS
SPOP
0.8502
More...
P38398
Breast cancer type 1 susceptibility protein
DEG_SPOP_SBC_1
586:590
PISSS
SPOP
0.963
More...
Q2KHR2
DNA-binding protein RFX7
DEG_SPOP_SBC_1
931:935
PISSS
SPOP
0.9118
More...
Q8IZH2
5'-3' exoribonuclease 1
DEG_SPOP_SBC_1
1684:1688
PISSS
SPOP
0.9961
More...
Q8N983
39S ribosomal protein L43, mitochondrial
DEG_SPOP_SBC_1
184:188
PISSS
SPOP
0.8798
More...
Q92908
Transcription factor GATA-6
DEG_SPOP_SBC_1
38:42
PISSS
SPOP
0.7589
More...
Q9UPS6
Histone-lysine N-methyltransferase SETD1B
DEG_SPOP_SBC_1
532:536
PISSS
SPOP
0.9978
More...
Q7M4L6
SH2 domain-containing adapter protein F
DEG_SPOP_SBC_1
62:66
PISSS
SPOP
0.9333
More...
A6NIR3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
DEG_SPOP_SBC_1
354:358
PISSS
SPOP
0.9883
More...
Q5VTM2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9
DEG_SPOP_SBC_1
399:403
PISSS
SPOP
0.9606
More...
Q5VUJ5
Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7
DEG_SPOP_SBC_1
331:335
PISSS
SPOP
0.9817
More...
Q5VW22
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6
DEG_SPOP_SBC_1
331:335
PISSS
SPOP
0.9118
More...
Q8TF27
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11
DEG_SPOP_SBC_1
193:197
PISSS
SPOP
0.9254
More...
Q9ULL0
Acrosomal protein KIAA1210
DEG_SPOP_SBC_1
1507:1511
PISSS
SPOP
0.9387
More...