DegronMD

Uniprot ID: P26367

Source protein: Paired box protein Pax-6

Source gene: PAX6

Class: DEG_SPOP_SBC_1

Location: 286:290

E3 ligase: SPOP

DEGRON score: 0.8502

ASA_SCORE: 54.72

COIL: 0.8876

CONS_SCORE: 0.6045

DSS_SCORE: 0.5227

HELIX: 0.0388

FCONS_SCORE: 1.2099

RIG_SCORE: 0.6403

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P296H	TCGA-39-5040	LUSC	TCGA	PISSS	DEG_SPOP_SBC_1	0.1667
p.R289I	TCGA-AG-A002	READ	TCGA	PISSS	DEG_SPOP_SBC_1	0.8102
p.R289I	SIDM01611	Endometrial Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.8102
p.R289I	ACH-000996	Endometrial/Uterine Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	0.8102
p.R290I	TCGA-BC-A69H	LIHC	TCGA	PISSS	DEG_SPOP_SBC_1	0.8102
p.R286K	TCGA-W3-AA1R	SKCM	TCGA	PISSS	DEG_SPOP_SBC_1	0.7237
p.S292N	DO222790	COCA	ICGC	PISSS	DEG_SPOP_SBC_1	0.2778
p.Q297K	DO229032	LICA	ICGC	PISSS	DEG_SPOP_SBC_1	0.1389
p.R276I	DO44927	LIHC	ICGC	PISSS	DEG_SPOP_SBC_1	0.0556
p.P282H	DO45436	LUSC	ICGC	PISSS	DEG_SPOP_SBC_1	0.2222
p.R290S	ACH-000467	Colon/Colorectal Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	0.7427
p.R290S	HCC-56	large_intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	0.7427
p.Q280E	MDA-MB-468	breast	COSMIC	PISSS	DEG_SPOP_SBC_1	0.1667
p.S279P	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	0.1389
p.R276S	HCC-56	large_intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	0.0556
p.A285T	NCI-SNU-1	stomach	COSMIC	PISSS	DEG_SPOP_SBC_1	0.3056
p.A299T	NCI-SNU-1	stomach	COSMIC	PISSS	DEG_SPOP_SBC_1	0.0833
p.P283L	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15444	C-C motif chemokine 25	DEG_SPOP_SBC_1	132:136	PISSS	SPOP	0.8813	More...
O75030	Microphthalmia-associated transcription factor	DEG_SPOP_SBC_1	47:51	PISSS	SPOP	0.9949	More...
O94864	STAGA complex 65 subunit gamma	DEG_SPOP_SBC_1	11:15	PISSS	SPOP	0.9981	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	314:318	PISSS	SPOP	0.9982	More...
P26367	Paired box protein Pax-6	DEG_SPOP_SBC_1	286:290	PISSS	SPOP	0.8502	More...
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	586:590	PISSS	SPOP	0.963	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	931:935	PISSS	SPOP	0.9118	More...
Q8IZH2	5'-3' exoribonuclease 1	DEG_SPOP_SBC_1	1684:1688	PISSS	SPOP	0.9961	More...
Q8N983	39S ribosomal protein L43, mitochondrial	DEG_SPOP_SBC_1	184:188	PISSS	SPOP	0.8798	More...
Q92908	Transcription factor GATA-6	DEG_SPOP_SBC_1	38:42	PISSS	SPOP	0.7589	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	532:536	PISSS	SPOP	0.9978	More...
Q7M4L6	SH2 domain-containing adapter protein F	DEG_SPOP_SBC_1	62:66	PISSS	SPOP	0.9333	More...
A6NIR3	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5	DEG_SPOP_SBC_1	354:358	PISSS	SPOP	0.9883	More...
Q5VTM2	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9	DEG_SPOP_SBC_1	399:403	PISSS	SPOP	0.9606	More...
Q5VUJ5	Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7	DEG_SPOP_SBC_1	331:335	PISSS	SPOP	0.9817	More...
Q5VW22	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6	DEG_SPOP_SBC_1	331:335	PISSS	SPOP	0.9118	More...
Q8TF27	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11	DEG_SPOP_SBC_1	193:197	PISSS	SPOP	0.9254	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1507:1511	PISSS	SPOP	0.9387	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PISSS

Degron related mutations and impact score

Drug responses associated with PAX6 mutations

All proteins holding degron of PISSS