DegronMD

Uniprot ID: Q92908

Source protein: Transcription factor GATA-6

Source gene: GATA6

Class: DEG_SCF_FBW7_1

Location: 512:519

E3 ligase: FBXW7

DEGRON score: 0.9985

ASA_SCORE: 104.575

COIL: 0.9724

CONS_SCORE: 0.4458

DSS_SCORE: 0.6495

HELIX: 0.0095

FCONS_SCORE: 1.164

RIG_SCORE: 0.5992

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N529K	TCGA-12-0688	GBM	TCGA	IPMTPTST	DEG_SCF_FBW7_1	0.0556
p.N529K	DO11088	GBM	ICGC	IPMTPTST	DEG_SCF_FBW7_1	0.0556
p.N529K	SIDM00193	Colorectal Carcinoma	GDSC	IPMTPTST	DEG_SCF_FBW7_1	0.0556
p.N529K	ACH-000991	Colon/Colorectal Cancer	CCLE	IPMTPTST	DEG_SCF_FBW7_1	0.0556
p.N529K	SNU-81	large_intestine	COSMIC	IPMTPTST	DEG_SCF_FBW7_1	0.0556
p.N529H	TCGA-64-1679	LUAD	TCGA	IPMTPTST	DEG_SCF_FBW7_1	0.0556
p.N529H	DO26200	LUAD	ICGC	IPMTPTST	DEG_SCF_FBW7_1	0.0556
p.P516L	TCGA-64-5781	LUAD	TCGA	IPMTPTST	DEG_SCF_FBW7_1	0.7582
p.P516L	DO23740	LUAD	ICGC	IPMTPTST	DEG_SCF_FBW7_1	0.7582
p.T503S	TCGA-BR-6452	STAD	TCGA	IPMTPTST	DEG_SCF_FBW7_1	0.0833
p.T503S	DO38404	STAD	ICGC	IPMTPTST	DEG_SCF_FBW7_1	0.0833
p.I512T	DO48404	BLCA	ICGC	IPMTPTST	DEG_SCF_FBW7_1	0.7078
p.D525N	DO222838	BTCA	ICGC	IPMTPTST	DEG_SCF_FBW7_1	0.1667
p.M514I	DO222838	BTCA	ICGC	IPMTPTST	DEG_SCF_FBW7_1	0.6507
p.T517A	DO233766	GACA	ICGC	IPMTPTST	DEG_SCF_FBW7_1	0.6028
p.C504F	DO229027	LICA	ICGC	IPMTPTST	DEG_SCF_FBW7_1	0.1111
p.K502M	SIDM01118	Small Cell Lung Carcinoma	GDSC	IPMTPTST	DEG_SCF_FBW7_1	0.1667
p.K502M	ACH-002175	Lung Cancer	CCLE	IPMTPTST	DEG_SCF_FBW7_1	0.1667
p.K502M	NCI-H740	lung	COSMIC	IPMTPTST	DEG_SCF_FBW7_1	0.1667
p.P513H	SIDM01739	Small Cell Lung Carcinoma	GDSC	IPMTPTST	DEG_SCF_FBW7_1	0.6583
p.P513H	ACH-000297	Lung Cancer	CCLE	IPMTPTST	DEG_SCF_FBW7_1	0.6583
p.T517I	ACH-001389	Breast Cancer	CCLE	IPMTPTST	DEG_SCF_FBW7_1	0.5966

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92908	Transcription factor GATA-6	DEG_SCF_FBW7_1	512:519	IPMTPTST	FBXW7	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons