DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PTSTS
Uniprot ID:
Q9Y580
Source protein:
RNA-binding protein 7
Source gene:
RBM7
Class:
DEG_SPOP_SBC_1
Location:
109:113
E3 ligase:
SPOP
DEGRON score:
0.9723
ASA_SCORE:
79.2
COIL:
0.9396
CONS_SCORE:
0.2636
DSS_SCORE:
0.7082
HELIX:
0.0244
FCONS_SCORE:
0.8636
RIG_SCORE:
0.5493
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T112A
DO229229
THCA
ICGC
PTSTS
DEG_SPOP_SBC_1
0.825
p.E118K
TCGA-EY-A1G8
UCEC
TCGA
PTSTS
DEG_SPOP_SBC_1
0.1944
p.H103R
TCGA-BR-6563
STAD
TCGA
PTSTS
DEG_SPOP_SBC_1
0.1667
p.H103R
DO38364
STAD
ICGC
PTSTS
DEG_SPOP_SBC_1
0.1667
p.H103D
DO228562
LICA
ICGC
PTSTS
DEG_SPOP_SBC_1
0.1667
p.E119K
DO43578
UCEC
ICGC
PTSTS
DEG_SPOP_SBC_1
0.1667
p.G103V
EJM
haematopoietic_and_lymphoid_tissue
COSMIC
PTSTS
DEG_SPOP_SBC_1
0.1667
p.P100S
DO229272
THCA
ICGC
PTSTS
DEG_SPOP_SBC_1
0.0833
Showing 1 to 8 of 8 entries
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Drug responses associated with RBM7 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PTSTS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86UB2
Basic immunoglobulin-like variable motif-containing protein
DEG_SPOP_SBC_1
113:117
PTSTS
SPOP
0.996
More...
Q8NEZ4
Histone-lysine N-methyltransferase 2C
DEG_SPOP_SBC_1
1838:1842
PTSTS
SPOP
0.8657
More...
Q659C4
La-related protein 1B
DEG_SPOP_SBC_1
888:892
PTSTS
SPOP
0.9366
More...
Q6ZMT4
Lysine-specific demethylase 7A
DEG_SPOP_SBC_1
725:729
PTSTS
SPOP
0.964
More...
P35658
Nuclear pore complex protein Nup214
DEG_SPOP_SBC_1
1764:1768
PTSTS
SPOP
0.7279
More...
Q12809
Potassium voltage-gated channel subfamily H member 2
DEG_SPOP_SBC_1
1088:1092
PTSTS
SPOP
0.9344
More...
A8MVS5
Protein HIDE1
DEG_SPOP_SBC_1
211:215
PTSTS
SPOP
0.9885
More...
Q5VT52
Regulation of nuclear pre-mRNA domain-containing protein 2
DEG_SPOP_SBC_1
712:716
PTSTS
SPOP
0.9904
More...
Q9Y580
RNA-binding protein 7
DEG_SPOP_SBC_1
109:113
PTSTS
SPOP
0.9723
More...
Q14140
SERTA domain-containing protein 2
DEG_SPOP_SBC_1
181:185
PTSTS
SPOP
0.9991
More...
Q8N5H7
SH2 domain-containing protein 3C
DEG_SPOP_SBC_1
378:382
PTSTS
SPOP
0.9446
More...
Q9UHA2
SS18-like protein 2
DEG_SPOP_SBC_1
69:73
PTSTS
SPOP
0.905
More...
Q92908
Transcription factor GATA-6
DEG_SPOP_SBC_1
516:520
PTSTS
SPOP
0.9952
More...
Q70CQ2
Ubiquitin carboxyl-terminal hydrolase 34
DEG_SPOP_SBC_1
3382:3386
PTSTS
SPOP
0.9803
More...
Q9H4Z2
Zinc finger protein 335
DEG_SPOP_SBC_1
200:204
PTSTS
SPOP
0.9952
More...
Showing 1 to 15 of 15 entries
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