DegronMD - Q8N0U2(TMEM61)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A51S	TCGA-24-1845	OV	TCGA	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.25
p.A51S	DO29920	OV	ICGC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.25
p.A171T	TCGA-28-5208	GBM	TCGA	PPSY	ITCH	174:177	Mutation rewiring degron network	0.25
p.A171T	TCGA-AA-3492	COAD	TCGA	PPSY	ITCH	174:177	Mutation rewiring degron network	0.25
p.A171T	DO8224	COAD	ICGC	PPSY	ITCH	174:177	Mutation rewiring degron network	0.25
p.A171T	DO12022	GBM	ICGC	PPSY	ITCH	174:177	Mutation rewiring degron network	0.25
p.A164V	TCGA-2W-A8YY	CESC	TCGA	PPSY	ITCH	174:177	Mutation rewiring degron network	0.0556
p.A164V	DO223732	CESC	ICGC	PPSY	ITCH	174:177	Mutation rewiring degron network	0.0556
p.E154D	TCGA-A5-A0G2	UCEC	TCGA	PPAY	ITCH	147:150	Mutation rewiring degron network	0.2222
p.E154D	DO41235	UCEC	ICGC	PPAY	ITCH	147:150	Mutation rewiring degron network	0.2222
p.P57L	TCGA-A6-2686	COAD	TCGA	TEYPVPEGP	DEG_COP1_1	54:62	Mutation altering degron motif	0.6471
p.P57L	TCGA-CV-7242	HNSC	TCGA	TEYPVPEGP	DEG_COP1_1	54:62	Mutation altering degron motif	0.6471
p.P57L	DO7828	COAD	ICGC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation altering degron motif	0.6471
p.P57L	DO14974	HNSC	ICGC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation altering degron motif	0.6471
p.P57L	SIDM00599	Osteosarcoma	GDSC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation altering degron motif	0.6471
p.P57L	ACH-001526	Bone Cancer	CCLE	TEYPVPEGP	DEG_COP1_1	54:62	Mutation altering degron motif	0.6471
p.P57L	HuO9	bone	COSMIC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation altering degron motif	0.6471
p.A155S	TCGA-AK-3444	KIRC	TCGA	PPAY	ITCH	147:150	Mutation rewiring degron network	0.1944
p.P47S	TCGA-B5-A0K2	UCEC	TCGA	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.1389
p.P47S	DO43835	UCEC	ICGC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.1389
p.S181G	TCGA-B5-A11J	UCEC	TCGA	PPSY	ITCH	174:177	Mutation rewiring degron network	0.2222
p.S181G	DO43698	UCEC	ICGC	PPSY	ITCH	174:177	Mutation rewiring degron network	0.2222
p.G61D	TCGA-BF-AAOX	SKCM	TCGA	TEYPVPEGP	DEG_COP1_1	54:62	Mutation altering degron motif	0.7198
p.G61D	DO223907	SKCM	ICGC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation altering degron motif	0.7198
p.E142D	TCGA-D1-A103	UCEC	TCGA	PPAY	ITCH	147:150	Mutation rewiring degron network	0.1944
p.E142D	DO42312	UCEC	ICGC	PPAY	ITCH	147:150	Mutation rewiring degron network	0.1944
p.E142K	TCGA-DK-A2I4	BLCA	TCGA	PPAY	ITCH	147:150	Mutation rewiring degron network	0.1944
p.E142K	DO465	BLCA	ICGC	PPAY	ITCH	147:150	Mutation rewiring degron network	0.1944
p.E142K	SIDM01588	Endometrial Carcinoma	GDSC	PPAY	ITCH	147:150	Mutation rewiring degron network	0.1944
p.E142K	ACH-000993	Endometrial/Uterine Cancer	CCLE	PPAY	ITCH	147:150	Mutation rewiring degron network	0.1944
p.D185Y	TCGA-EO-A22X	UCEC	TCGA	PPSY	ITCH	174:177	Mutation rewiring degron network	0.1111
p.D185Y	DO43907	UCEC	ICGC	PPSY	ITCH	174:177	Mutation rewiring degron network	0.1111
p.S167I	TCGA-FI-A2D5	UCEC	TCGA	PPSY	ITCH	174:177	Mutation rewiring degron network	0.1389
p.S167I	DO41331	UCEC	ICGC	PPSY	ITCH	174:177	Mutation rewiring degron network	0.1389
p.E178K	TCGA-FW-A3R5	SKCM	TCGA	PPSY	ITCH	174:177	Mutation rewiring degron network	0.3056
p.E178K	DO37406	SKCM	ICGC	PPSY	ITCH	174:177	Mutation rewiring degron network	0.3056
p.V187I	TCGA-HU-8243	STAD	TCGA	PPSY	ITCH	174:177	Mutation rewiring degron network	0.0556
p.V187I	DO47915	STAD	ICGC	PPSY	ITCH	174:177	Mutation rewiring degron network	0.0556
p.S63G	TCGA-VQ-A8PO	STAD	TCGA	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.3056
p.S63G	DO51773	STAD	ICGC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.3056
p.P59H	DO50090	COAD	ICGC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation altering degron motif	0.7694
p.A45T	DO233748	GACA	ICGC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.0833
p.V72F	DO229018	LICA	ICGC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.0556
p.G48C	DO229019	LICA	ICGC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.1667
p.R67T	DO23418	LINC	ICGC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.1944
p.V72I	DO27783	MALY	ICGC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.0556
p.V72I	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.0556
p.V72I	SIDM01743	Melanoma	GDSC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.0556
p.V72I	SW900	lung	COSMIC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.0556
p.P57Q	DO220877	MELA	ICGC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation altering degron motif	0.5924
p.P57S	DO222494	MELA	ICGC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation altering degron motif	0.5641
p.D185E	DO233298	NACA	ICGC	PPSY	ITCH	174:177	Mutation rewiring degron network	0.1111
p.A45V	DO50727	ORCA	ICGC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.0833
p.P64S	SIDM01245	T-Lymphoblastic Leukemia	GDSC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.2778
p.P64S	ACH-002216	Leukemia	CCLE	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.2778
p.P64S	BE-13	haematopoietic and lymphoid tissue	COSMIC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.2778
p.S68F	SIDM01079	Melanoma	GDSC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.1667
p.S68F	ACH-000441	Skin Cancer	CCLE	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.1667
p.S68F	SH-4	skin	COSMIC	TEYPVPEGP	DEG_COP1_1	54:62	Mutation rewiring degron network	0.1667
p.P148H	SIDM00112	Kidney Carcinoma	GDSC	PPAY	ITCH	147:150	Mutation altering degron motif	0.7694
p.P148H	SIDM00674	Non-Cancerous	GDSC	PPAY	ITCH	147:150	Mutation altering degron motif	0.7694
p.D185N	SIDM00247	Gastric Carcinoma	GDSC	PPSY	ITCH	174:177	Mutation rewiring degron network	0.1111
p.D185N	ACH-000356	Gastric Cancer	CCLE	PPSY	ITCH	174:177	Mutation rewiring degron network	0.1111
p.D185N	MKN45	stomach	COSMIC	PPSY	ITCH	174:177	Mutation rewiring degron network	0.1111
p.S176R	SIDM01760	Rhabdomyosarcoma	GDSC	PPSY	ITCH	174:177	Mutation altering degron motif	0.6316
p.S176R	ACH-000051	Sarcoma	CCLE	PPSY	ITCH	174:177	Mutation altering degron motif	0.6316
p.S181N	SIDM01588	Endometrial Carcinoma	GDSC	PPSY	ITCH	174:177	Mutation rewiring degron network	0.2222
p.S181N	ACH-000993	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	174:177	Mutation rewiring degron network	0.2222
p.A183G	ACH-000837	Lung Cancer	CCLE	PPSY	ITCH	174:177	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM61

UniProt ID: Q8N0U2

Entrez ID: 199964

Protein name: Transmembrane protein 61

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM61 in