DegronMD

Uniprot ID: Q8N0U2

Source protein: Transmembrane protein 61

Source gene: TMEM61

Class: DEG_COP1_1

Location: 54:62

E3 ligase: COP1

DEGRON score: 0.7197

ASA_SCORE: 89.6778

COIL: 0.9359

CONS_SCORE: 0.9177

DSS_SCORE: 0.4325

HELIX: 0.0318

FCONS_SCORE: 0.9725

RIG_SCORE: 0.695

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A51S	TCGA-24-1845	OV	TCGA	TEYPVPEGP	DEG_COP1_1	0.25
p.A51S	DO29920	OV	ICGC	TEYPVPEGP	DEG_COP1_1	0.25
p.P57L	TCGA-A6-2686	COAD	TCGA	TEYPVPEGP	DEG_COP1_1	0.6471
p.P57L	TCGA-CV-7242	HNSC	TCGA	TEYPVPEGP	DEG_COP1_1	0.6471
p.P57L	DO7828	COAD	ICGC	TEYPVPEGP	DEG_COP1_1	0.6471
p.P57L	DO14974	HNSC	ICGC	TEYPVPEGP	DEG_COP1_1	0.6471
p.P57L	SIDM00599	Osteosarcoma	GDSC	TEYPVPEGP	DEG_COP1_1	0.6471
p.P57L	ACH-001526	Bone Cancer	CCLE	TEYPVPEGP	DEG_COP1_1	0.6471
p.P57L	HuO9	bone	COSMIC	TEYPVPEGP	DEG_COP1_1	0.6471
p.P47S	TCGA-B5-A0K2	UCEC	TCGA	TEYPVPEGP	DEG_COP1_1	0.1389
p.P47S	DO43835	UCEC	ICGC	TEYPVPEGP	DEG_COP1_1	0.1389
p.G61D	TCGA-BF-AAOX	SKCM	TCGA	TEYPVPEGP	DEG_COP1_1	0.7198
p.G61D	DO223907	SKCM	ICGC	TEYPVPEGP	DEG_COP1_1	0.7198
p.S63G	TCGA-VQ-A8PO	STAD	TCGA	TEYPVPEGP	DEG_COP1_1	0.3056
p.S63G	DO51773	STAD	ICGC	TEYPVPEGP	DEG_COP1_1	0.3056
p.P59H	DO50090	COAD	ICGC	TEYPVPEGP	DEG_COP1_1	0.7694
p.A45T	DO233748	GACA	ICGC	TEYPVPEGP	DEG_COP1_1	0.0833
p.V72F	DO229018	LICA	ICGC	TEYPVPEGP	DEG_COP1_1	0.0556
p.G48C	DO229019	LICA	ICGC	TEYPVPEGP	DEG_COP1_1	0.1667
p.R67T	DO23418	LINC	ICGC	TEYPVPEGP	DEG_COP1_1	0.1944
p.V72I	DO27783	MALY	ICGC	TEYPVPEGP	DEG_COP1_1	0.0556
p.V72I	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	TEYPVPEGP	DEG_COP1_1	0.0556
p.V72I	SIDM01743	Melanoma	GDSC	TEYPVPEGP	DEG_COP1_1	0.0556
p.V72I	SW900	lung	COSMIC	TEYPVPEGP	DEG_COP1_1	0.0556
p.P57Q	DO220877	MELA	ICGC	TEYPVPEGP	DEG_COP1_1	0.5924
p.P57S	DO222494	MELA	ICGC	TEYPVPEGP	DEG_COP1_1	0.5641
p.A45V	DO50727	ORCA	ICGC	TEYPVPEGP	DEG_COP1_1	0.0833
p.P64S	SIDM01245	T-Lymphoblastic Leukemia	GDSC	TEYPVPEGP	DEG_COP1_1	0.2778
p.P64S	ACH-002216	Leukemia	CCLE	TEYPVPEGP	DEG_COP1_1	0.2778
p.P64S	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	TEYPVPEGP	DEG_COP1_1	0.2778
p.S68F	SIDM01079	Melanoma	GDSC	TEYPVPEGP	DEG_COP1_1	0.1667
p.S68F	ACH-000441	Skin Cancer	CCLE	TEYPVPEGP	DEG_COP1_1	0.1667
p.S68F	SH-4	skin	COSMIC	TEYPVPEGP	DEG_COP1_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TEYPVPEGP

Degron related mutations and impact score

Drug responses associated with TMEM61 mutations

All proteins holding degron of TEYPVPEGP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N0U2	Transmembrane protein 61	DEG_COP1_1	54:62	TEYPVPEGP	COP1	0.7197	More...