DegronMD - Q9NWM3(CUEDC1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P133R	TCGA-22-5483	LUSC	TCGA	PPAY	ITCH	133:136	Mutation altering degron motif	0.7512
p.P133R	DO26614	LUSC	ICGC	PPAY	ITCH	133:136	Mutation altering degron motif	0.7512
p.D121H	TCGA-43-8116	LUSC	TCGA	PPVY	ITCH	128:131	Mutation rewiring degron network	0.1389
p.D121H	DO27349	LUSC	ICGC	PPVY	ITCH	128:131	Mutation rewiring degron network	0.1389
p.E300K	TCGA-85-A4CL	LUSC	TCGA	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.H310R	TCGA-B5-A11E	UCEC	TCGA	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation altering degron motif	0.7133
p.P296S	TCGA-CN-A63V	HNSC	TCGA	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.1111
p.P296H	TCGA-EJ-7125	PRAD	TCGA	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.1111
p.S299F	TCGA-FG-6688	LGG	TCGA	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.1944
p.A294V	TCGA-YG-AA3O	SKCM	TCGA	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.0556
p.L127F	DO779	BLCA	ICGC	PPVY	ITCH	128:131	Mutation rewiring degron network	0.3056
p.L127F	DO779	BLCA	ICGC	PPAY	ITCH	133:136	Mutation rewiring degron network	0.1667
p.A140T	DO222404	BTCA	ICGC	PPVY	ITCH	128:131	Mutation rewiring degron network	0.0833
p.A140T	DO222404	BTCA	ICGC	PPAY	ITCH	133:136	Mutation rewiring degron network	0.2222
p.Y129H	DO16560	KIRC	ICGC	PPVY	ITCH	128:131	Mutation altering degron motif	0.7229
p.N143K	DO229027	LICA	ICGC	PPAY	ITCH	133:136	Mutation rewiring degron network	0.1389
p.H139N	DO229027	LICA	ICGC	PPVY	ITCH	128:131	Mutation rewiring degron network	0.1111
p.H139N	DO229027	LICA	ICGC	PPAY	ITCH	133:136	Mutation rewiring degron network	0.25
p.D144N	DO50076	UCEC	ICGC	PPAY	ITCH	133:136	Mutation rewiring degron network	0.1111
p.R316Q	SIDM01265	Plasma Cell Myeloma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM00773	Non-Cancerous	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM00969	Ovarian Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM01117	Small Cell Lung Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM00846	Cervical Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM01112	Osteosarcoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM00650	Small Cell Lung Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM00879	Breast Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM00806	Osteosarcoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM00254	Neuroblastoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM00309	Mesothelioma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM01147	Gastric Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM00431	T-Lymphoblastic Leukemia	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM00863	Burkitt's Lymphoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM01681	Non-Cancerous	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM00118	Colorectal Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM00774	Breast Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM00720	Mesothelioma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM00760	Small Cell Lung Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM00785	Acute Myeloid Leukemia	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R316Q	SIDM01318	Hepatocellular Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	304:312	Mutation rewiring degron network	0.2222
p.R143W	SIDM01146	Gastric Carcinoma	GDSC	PPAY	ITCH	133:136	Mutation rewiring degron network	0.1389
p.R143W	ACH-000932	Gastric Cancer	CCLE	PPAY	ITCH	133:136	Mutation rewiring degron network	0.1389
p.R143W	NCI-SNU-1	stomach	COSMIC	PPAY	ITCH	133:136	Mutation rewiring degron network	0.1389
p.R143Q	SIDM00954	Breast Carcinoma	GDSC	PPAY	ITCH	133:136	Mutation rewiring degron network	0.1389
p.V140M	ACH-000608	Ovarian Cancer	CCLE	PPVY	ITCH	128:131	Mutation rewiring degron network	0.0833
p.V140M	ACH-000608	Ovarian Cancer	CCLE	PPAY	ITCH	133:136	Mutation rewiring degron network	0.2222
p.Y136C	ACH-000634	Brain Cancer	CCLE	PPAY	ITCH	133:136	Mutation altering degron motif	0.7087
p.S137N	NCI-H1155	lung	COSMIC	PPVY	ITCH	128:131	Mutation rewiring degron network	0.1667
p.S137N	NCI-H1155	lung	COSMIC	PPAY	ITCH	133:136	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CUEDC1

UniProt ID: Q9NWM3

Entrez ID: 404093

Protein name: CUE domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CUEDC1 in