DegronMD

Uniprot ID: Q9NWM3

Source protein: CUE domain-containing protein 1

Source gene: CUEDC1

Class: DEG_APCC_DBOX_1

Location: 304:312

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9438

ASA_SCORE: 80.8222

COIL: 0.3889

CONS_SCORE: 0.5698

DSS_SCORE: 0.4512

HELIX: 0.611

FCONS_SCORE: 1.2445

RIG_SCORE: 0.7701

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E300K	TCGA-85-A4CL	LUSC	TCGA	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.H310R	TCGA-B5-A11E	UCEC	TCGA	FRDKLKHMG	DEG_APCC_DBOX_1	0.7133
p.P296S	TCGA-CN-A63V	HNSC	TCGA	FRDKLKHMG	DEG_APCC_DBOX_1	0.1111
p.P296H	TCGA-EJ-7125	PRAD	TCGA	FRDKLKHMG	DEG_APCC_DBOX_1	0.1111
p.S299F	TCGA-FG-6688	LGG	TCGA	FRDKLKHMG	DEG_APCC_DBOX_1	0.1944
p.A294V	TCGA-YG-AA3O	SKCM	TCGA	FRDKLKHMG	DEG_APCC_DBOX_1	0.0556
p.R316Q	SIDM01265	Plasma Cell Myeloma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM00773	Non-Cancerous	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM00969	Ovarian Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM01117	Small Cell Lung Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM00846	Cervical Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM01112	Osteosarcoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM00650	Small Cell Lung Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM00879	Breast Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM00806	Osteosarcoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM00254	Neuroblastoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM00309	Mesothelioma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM01147	Gastric Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM00431	T-Lymphoblastic Leukemia	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM00863	Burkitt's Lymphoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM01681	Non-Cancerous	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM00118	Colorectal Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM00774	Breast Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM00720	Mesothelioma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM00760	Small Cell Lung Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM00785	Acute Myeloid Leukemia	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222
p.R316Q	SIDM01318	Hepatocellular Carcinoma	GDSC	FRDKLKHMG	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FRDKLKHMG

Degron related mutations and impact score

Drug responses associated with CUEDC1 mutations

All proteins holding degron of FRDKLKHMG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NWM3	CUE domain-containing protein 1	DEG_APCC_DBOX_1	304:312	FRDKLKHMG	APC,CDC20,FZR1	0.9438	More...