DegronMD - Q9H4L4(SENP3)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R33H	TCGA-26-6174	GBM	TCGA	PPAY	ITCH	21:24	Mutation rewiring degron network	0.0833
p.R33H	TCGA-FI-A2D0	UCEC	TCGA	PPAY	ITCH	21:24	Mutation rewiring degron network	0.0833
p.R33H	DO11076	GBM	ICGC	PPAY	ITCH	21:24	Mutation rewiring degron network	0.0833
p.R33H	DO43891	UCEC	ICGC	PPAY	ITCH	21:24	Mutation rewiring degron network	0.0833
p.P246H	TCGA-85-6561	LUSC	TCGA	DSGLLS	DEG_SCF_TRCP1_1	237:242	Mutation rewiring degron network	0.2222
p.P246H	DO26518	LUSC	ICGC	DSGLLS	DEG_SCF_TRCP1_1	237:242	Mutation rewiring degron network	0.2222
p.P233S	TCGA-AD-6895	COAD	TCGA	DSGLLS	DEG_SCF_TRCP1_1	237:242	Mutation rewiring degron network	0.2222
p.P233S	DO8938	COAD	ICGC	DSGLLS	DEG_SCF_TRCP1_1	237:242	Mutation rewiring degron network	0.2222
p.R31H	TCGA-AX-A2HD	UCEC	TCGA	PPAY	ITCH	21:24	Mutation rewiring degron network	0.1389
p.R31H	TCGA-B5-A1MR	UCEC	TCGA	PPAY	ITCH	21:24	Mutation rewiring degron network	0.1389
p.R31H	TCGA-E7-A6MD	BLCA	TCGA	PPAY	ITCH	21:24	Mutation rewiring degron network	0.1389
p.R31H	DO219015	BLCA	ICGC	PPAY	ITCH	21:24	Mutation rewiring degron network	0.1389
p.R31H	DO41758	UCEC	ICGC	PPAY	ITCH	21:24	Mutation rewiring degron network	0.1389
p.R31H	DO42608	UCEC	ICGC	PPAY	ITCH	21:24	Mutation rewiring degron network	0.1389
p.R29W	TCGA-AZ-4315	COAD	TCGA	PPAY	ITCH	21:24	Mutation rewiring degron network	0.1944
p.R29W	DO8842	COAD	ICGC	PPAY	ITCH	21:24	Mutation rewiring degron network	0.1944
p.R227M	TCGA-BF-A1Q0	SKCM	TCGA	DSGLLS	DEG_SCF_TRCP1_1	237:242	Mutation rewiring degron network	0.0556
p.R227M	DO47374	SKCM	ICGC	DSGLLS	DEG_SCF_TRCP1_1	237:242	Mutation rewiring degron network	0.0556
p.R28S	TCGA-D1-A1NZ	UCEC	TCGA	PPAY	ITCH	21:24	Mutation rewiring degron network	0.2222
p.R28S	DO41536	UCEC	ICGC	PPAY	ITCH	21:24	Mutation rewiring degron network	0.2222
p.P27S	TCGA-DK-A6B6	BLCA	TCGA	PPAY	ITCH	21:24	Mutation rewiring degron network	0.25
p.P27S	DO48576	BLCA	ICGC	PPAY	ITCH	21:24	Mutation rewiring degron network	0.25
p.P233L	TCGA-EB-A51B	SKCM	TCGA	DSGLLS	DEG_SCF_TRCP1_1	237:242	Mutation rewiring degron network	0.2222
p.P233L	DO47343	SKCM	ICGC	DSGLLS	DEG_SCF_TRCP1_1	237:242	Mutation rewiring degron network	0.2222
p.G248C	TCGA-EE-A2M7	SKCM	TCGA	DSGLLS	DEG_SCF_TRCP1_1	237:242	Mutation rewiring degron network	0.1667
p.G248C	DO37847	SKCM	ICGC	DSGLLS	DEG_SCF_TRCP1_1	237:242	Mutation rewiring degron network	0.1667
p.P15H	TCGA-ER-A19P	SKCM	TCGA	PPAY	ITCH	21:24	Mutation rewiring degron network	0.1667
p.P15H	DO47623	SKCM	ICGC	PPAY	ITCH	21:24	Mutation rewiring degron network	0.1667
p.A23V	TCGA-FI-A2D0	UCEC	TCGA	PPAY	ITCH	21:24	Mutation altering degron motif	0.5825
p.A23V	DO43891	UCEC	ICGC	PPAY	ITCH	21:24	Mutation altering degron motif	0.5825
p.R29L	TCGA-GL-6846	KIRP	TCGA	PPAY	ITCH	21:24	Mutation rewiring degron network	0.1944
p.R29L	DO20808	KIRP	ICGC	PPAY	ITCH	21:24	Mutation rewiring degron network	0.1944
p.P246S	DO234151	ESAD	ICGC	DSGLLS	DEG_SCF_TRCP1_1	237:242	Mutation rewiring degron network	0.2222
p.D237N	DO233780	GACA	ICGC	DSGLLS	DEG_SCF_TRCP1_1	237:242	Mutation altering degron motif	0.6932
p.G12R	DO231844	LINC	ICGC	PPAY	ITCH	21:24	Mutation rewiring degron network	0.0833
p.E14Q	DO50684	ORCA	ICGC	PPAY	ITCH	21:24	Mutation rewiring degron network	0.1389
p.R227S	SIDM01119	Other Solid Cancers	GDSC	DSGLLS	DEG_SCF_TRCP1_1	237:242	Mutation rewiring degron network	0.0556
p.R227S	ACH-000775	Lung Cancer	CCLE	DSGLLS	DEG_SCF_TRCP1_1	237:242	Mutation rewiring degron network	0.0556
p.R227S	NCI-H727	lung	COSMIC	DSGLLS	DEG_SCF_TRCP1_1	237:242	Mutation rewiring degron network	0.0556

Kaplan plot for SENP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SENP3

UniProt ID: Q9H4L4

Entrez ID: 26168

Protein name: Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SENP3 in