DegronMD

Uniprot ID: Q9H4L4

Source protein: Sentrin-specific protease 3

Source gene: SENP3

Class: DEG_SCF_TRCP1_1

Location: 237:242

E3 ligase: BTRC

DEGRON score: 0.9973

ASA_SCORE: 69.5167

COIL: 0.7582

CONS_SCORE: 0.3653

DSS_SCORE: 0.6058

HELIX: 0.1643

FCONS_SCORE: 1.0113

RIG_SCORE: 0.6822

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P246H	TCGA-85-6561	LUSC	TCGA	DSGLLS	DEG_SCF_TRCP1_1	0.2222
p.P246H	DO26518	LUSC	ICGC	DSGLLS	DEG_SCF_TRCP1_1	0.2222
p.P233S	TCGA-AD-6895	COAD	TCGA	DSGLLS	DEG_SCF_TRCP1_1	0.2222
p.P233S	DO8938	COAD	ICGC	DSGLLS	DEG_SCF_TRCP1_1	0.2222
p.R227M	TCGA-BF-A1Q0	SKCM	TCGA	DSGLLS	DEG_SCF_TRCP1_1	0.0556
p.R227M	DO47374	SKCM	ICGC	DSGLLS	DEG_SCF_TRCP1_1	0.0556
p.P233L	TCGA-EB-A51B	SKCM	TCGA	DSGLLS	DEG_SCF_TRCP1_1	0.2222
p.P233L	DO47343	SKCM	ICGC	DSGLLS	DEG_SCF_TRCP1_1	0.2222
p.G248C	TCGA-EE-A2M7	SKCM	TCGA	DSGLLS	DEG_SCF_TRCP1_1	0.1667
p.G248C	DO37847	SKCM	ICGC	DSGLLS	DEG_SCF_TRCP1_1	0.1667
p.P246S	DO234151	ESAD	ICGC	DSGLLS	DEG_SCF_TRCP1_1	0.2222
p.D237N	DO233780	GACA	ICGC	DSGLLS	DEG_SCF_TRCP1_1	0.6932
p.R227S	SIDM01119	Other Solid Cancers	GDSC	DSGLLS	DEG_SCF_TRCP1_1	0.0556
p.R227S	ACH-000775	Lung Cancer	CCLE	DSGLLS	DEG_SCF_TRCP1_1	0.0556
p.R227S	NCI-H727	lung	COSMIC	DSGLLS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4L4	Sentrin-specific protease 3	DEG_SCF_TRCP1_1	237:242	DSGLLS	BTRC	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons