DegronMD

Uniprot ID: P78314

Source protein: SH3 domain-binding protein 2

Source gene: SH3BP2

Class: ITCH

Location: 201:204

E3 ligase: ITCH,NEDD4

DEGRON score: 0.958

ASA_SCORE: 102.025

COIL: 0.979

CONS_SCORE: 0.5738

DSS_SCORE: 0.7153

HELIX: 0.0095

FCONS_SCORE: 1.4381

RIG_SCORE: 0.5618

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D205N	DO220879	MELA	ICGC	PPAY	ITCH	0.3056
p.M199I	ACH-000981	Leukemia	CCLE	PPAY	ITCH	0.2778
p.M199I	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PPAY	ITCH	0.2778
p.P206S	ACH-001624	Brain Cancer	CCLE	PPAY	ITCH	0.2778
p.P207S	ACH-002165	Skin Cancer	CCLE	PPAY	ITCH	0.25
p.P207S	MZ2-MEL	skin	COSMIC	PPAY	ITCH	0.25
p.S208I	TCGA-AX-A1CE	UCEC	TCGA	PPAY	ITCH	0.2222
p.S208I	DO42280	UCEC	ICGC	PPAY	ITCH	0.2222
p.P210S	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PPAY	ITCH	0.1667
p.A212T	TCGA-06-5416	GBM	TCGA	PPAY	ITCH	0.1111
p.R213K	ACH-000965	Endometrial/Uterine Cancer	CCLE	PPAY	ITCH	0.0833
p.R213K	RL95-2	endometrium	COSMIC	PPAY	ITCH	0.0833
p.E191K	TCGA-EO-A22R	UCEC	TCGA	PPAY	ITCH	0.0556

Showing 1 to 13 of 13 entries

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Drug responses associated with SH3BP2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPAY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07912	Activated CDC42 kinase 1	ITCH	632:635	PPAY	ITCH,NEDD4	0.9991	More...
P37088	Amiloride-sensitive sodium channel subunit alpha	ITCH	641:644	PPAY	ITCH,NEDD4	0.9695	More...
O14497	AT-rich interactive domain-containing protein 1A	ITCH	145:148	PPAY	ITCH,NEDD4	0.9015	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	ITCH	843:846	PPAY	ITCH,NEDD4	0.9548	More...
Q99700	Ataxin-2	ITCH	1031:1034	PPAY	ITCH,NEDD4	0.991	More...
O95415	Brain protein I3	ITCH	11:14	PPAY	ITCH,NEDD4	0.9941	More...
O75952	Calcium-binding tyrosine phosphorylation-regulated protein	ITCH	270:273	PPAY	ITCH,NEDD4	0.9464	More...
Q8NFW1	Collagen alpha-1	ITCH	1488:1491	PPAY	ITCH,NEDD4	0.9918	More...
Q9NWM3	CUE domain-containing protein 1	ITCH	133:136	PPAY	ITCH,NEDD4	0.993	More...
Q8IV13	Cyclin-J-like protein	ITCH	330:333	PPAY	ITCH,NEDD4	0.9938	More...
O75909	Cyclin-K	ITCH	462:465	PPAY	ITCH,NEDD4	0.5914	More...
Q15038	DAZ-associated protein 2	ITCH	39:42	PPAY	ITCH,NEDD4	0.9779	More...
Q96EP0	E3 ubiquitin-protein ligase RNF31	ITCH	1046:1049	PPAY	ITCH,NEDD4	0.6799	More...
P18146	Early growth response protein 1	ITCH	237:240	PPAY	ITCH,NEDD4	0.9972	More...
A6NMB9	Fidgetin-like protein 2	ITCH	415:418	PPAY	ITCH,NEDD4	0.9107	More...
Q8N144	Gap junction delta-3 protein	ITCH	262:265	PPAY	ITCH,NEDD4	0.9919	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	ITCH	781:784	PPAY	ITCH,NEDD4	0.9594	More...
A6NMT0	Homeobox protein DBX1	ITCH	50:53	PPAY	ITCH,NEDD4	0.9932	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	ITCH	156:159	PPAY	ITCH,NEDD4	0.9989	More...
Q96JM7	Lethal	ITCH	84:87	PPAY	ITCH,NEDD4	0.8976	More...
O43561	Linker for activation of T-cells family member 1	ITCH	61:64	PPAY	ITCH,NEDD4	0.9978	More...
Q16655	Melanoma antigen recognized by T-cells 1	ITCH	101:104	PPAY	ITCH,NEDD4	0.9993	More...
O75121	Microfibrillar-associated protein 3-like	ITCH	384:387	PPAY	ITCH,NEDD4	0.9598	More...
Q15797	Mothers against decapentaplegic homolog 1	ITCH	224:227	PPAY	ITCH,NEDD4	0.9965	More...
Q99717	Mothers against decapentaplegic homolog 5	ITCH	223:226	PPAY	ITCH,NEDD4	0.9821	More...

Showing 1 to 25 of 64 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPAY

Degron related mutations and impact score

Drug responses associated with SH3BP2 mutations

All proteins holding degron of PPAY