DegronMD

Uniprot ID: O14640

Source protein: Segment polarity protein dishevelled homolog DVL-1

Source gene: DVL1

Class: ITCH

Location: 550:553

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9898

ASA_SCORE: 69.55

COIL: 0.9023

CONS_SCORE: 0.5973

DSS_SCORE: 0.5574

HELIX: 0.0483

FCONS_SCORE: 1.439

RIG_SCORE: 0.6975

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q543L	TCGA-33-4566	LUSC	TCGA	PPAY	ITCH	0.1389
p.Q543L	DO26790	LUSC	ICGC	PPAY	ITCH	0.1389
p.G547V	TCGA-EE-A2GH	SKCM	TCGA	PPAY	ITCH	0.25
p.G547V	DO37643	SKCM	ICGC	PPAY	ITCH	0.25
p.R563C	DO222653	MELA	ICGC	PPAY	ITCH	0.0556
p.R563C	MES-SA	soft_tissue	COSMIC	PPAY	ITCH	0.0556
p.R558S	DO229218	THCA	ICGC	PPAY	ITCH	0.1944
p.Y542C	ACH-001610	Brain Cancer	CCLE	PPAY	ITCH	0.1111
p.R555Q	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	PPAY	ITCH	0.2778

Drug responses associated with DVL1 mutations

All proteins holding degron of PPAY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14497	AT-rich interactive domain-containing protein 1A	ITCH	145:148	PPAY	ITCH,NEDD4	0.9015	More...
O14559	Rho GTPase-activating protein 33	ITCH	1239:1242	PPAY	ITCH,NEDD4	0.9826	More...
O14640	Segment polarity protein dishevelled homolog DVL-1	ITCH	550:553	PPAY	ITCH,NEDD4	0.9898	More...
O14828	Secretory carrier-associated membrane protein 3	ITCH	50:53	PPAY	ITCH,NEDD4	0.9489	More...
O43561	Linker for activation of T-cells family member 1	ITCH	61:64	PPAY	ITCH,NEDD4	0.9978	More...
O75121	Microfibrillar-associated protein 3-like	ITCH	384:387	PPAY	ITCH,NEDD4	0.9598	More...
O75204	Transmembrane protein 127	ITCH	233:236	PPAY	ITCH,NEDD4	0.9861	More...
O75909	Cyclin-K	ITCH	462:465	PPAY	ITCH,NEDD4	0.5914	More...
O75952	Calcium-binding tyrosine phosphorylation-regulated protein	ITCH	270:273	PPAY	ITCH,NEDD4	0.9464	More...
O95415	Brain protein I3	ITCH	11:14	PPAY	ITCH,NEDD4	0.9941	More...
P18146	Early growth response protein 1	ITCH	237:240	PPAY	ITCH,NEDD4	0.9972	More...
P37088	Amiloride-sensitive sodium channel subunit alpha	ITCH	641:644	PPAY	ITCH,NEDD4	0.9695	More...
P43146	Netrin receptor DCC	ITCH	550:553	PPAY	ITCH,NEDD4	0.8629	More...
P78314	SH3 domain-binding protein 2	ITCH	201:204	PPAY	ITCH,NEDD4	0.958	More...
Q01892	Transcription factor Spi-B	ITCH	117:120	PPAY	ITCH,NEDD4	0.8619	More...
Q07912	Activated CDC42 kinase 1	ITCH	632:635	PPAY	ITCH,NEDD4	0.9991	More...
Q12809	Potassium voltage-gated channel subfamily H member 2	ITCH	1075:1078	PPAY	ITCH,NEDD4	0.9406	More...
Q14896	Myosin-binding protein C, cardiac-type	ITCH	794:797	PPAY	ITCH,NEDD4	0.9759	More...
Q15038	DAZ-associated protein 2	ITCH	39:42	PPAY	ITCH,NEDD4	0.9779	More...
Q15303	Receptor tyrosine-protein kinase erbB-4	ITCH	1053:1056	PPAY	ITCH,NEDD4	0.9956	More...
Q15468	SCL-interrupting locus protein	ITCH	508:511	PPAY	ITCH,NEDD4	0.9814	More...
Q15654	Thyroid receptor-interacting protein 6	ITCH	128:131	PPAY	ITCH,NEDD4	0.9801	More...
Q15797	Mothers against decapentaplegic homolog 1	ITCH	224:227	PPAY	ITCH,NEDD4	0.9965	More...
Q16655	Melanoma antigen recognized by T-cells 1	ITCH	101:104	PPAY	ITCH,NEDD4	0.9993	More...
Q5ST30	Valine--tRNA ligase, mitochondrial	ITCH	101:104	PPAY	ITCH,NEDD4	0.7036	More...
Q5T5C0	Syntaxin-binding protein 5	ITCH	872:875	PPAY	ITCH,NEDD4	0.9594	More...
Q5VX71	Sushi domain-containing protein 4	ITCH	411:414	PPAY	ITCH,NEDD4	0.9882	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	ITCH	156:159	PPAY	ITCH,NEDD4	0.9989	More...
Q8N0X7	Spartin	ITCH	171:174	PPAY	ITCH,NEDD4	0.9972	More...
Q8N114	Protein shisa-5	ITCH	206:209	PPAY	ITCH,NEDD4	0.9175	More...
Q8N144	Gap junction delta-3 protein	ITCH	262:265	PPAY	ITCH,NEDD4	0.9919	More...
Q8N5H7	SH2 domain-containing protein 3C	ITCH	64:67	PPAY	ITCH,NEDD4	0.9787	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	ITCH	843:846	PPAY	ITCH,NEDD4	0.9548	More...
Q8NFW1	Collagen alpha-1	ITCH	1488:1491	PPAY	ITCH,NEDD4	0.9918	More...
Q92738	USP6 N-terminal-like protein	ITCH	809:812	PPAY	ITCH,NEDD4	0.9809	More...
Q96AW1	Vesicular, overexpressed in cancer, prosurvival protein 1	ITCH	154:157	PPAY	ITCH,NEDD4	0.97	More...
Q96EP0	E3 ubiquitin-protein ligase RNF31	ITCH	1046:1049	PPAY	ITCH,NEDD4	0.6799	More...
Q96JM7	Lethal	ITCH	84:87	PPAY	ITCH,NEDD4	0.8976	More...
Q99700	Ataxin-2	ITCH	1031:1034	PPAY	ITCH,NEDD4	0.991	More...
Q99717	Mothers against decapentaplegic homolog 5	ITCH	223:226	PPAY	ITCH,NEDD4	0.9821	More...
Q9BSR8	Protein YIPF4	ITCH	7:10	PPAY	ITCH,NEDD4	0.9115	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	ITCH	781:784	PPAY	ITCH,NEDD4	0.9594	More...
Q9C0K7	STE20-related kinase adapter protein beta	ITCH	385:388	PPAY	ITCH,NEDD4	0.9824	More...
Q9H4L4	Sentrin-specific protease 3	ITCH	21:24	PPAY	ITCH,NEDD4	0.9368	More...
Q9NS40	Potassium voltage-gated channel subfamily H member 7	ITCH	1068:1071	PPAY	ITCH,NEDD4	0.8974	More...
Q9NVU7	Protein SDA1 homolog	ITCH	24:27	PPAY	ITCH,NEDD4	0.7681	More...
Q9UPU5	Ubiquitin carboxyl-terminal hydrolase 24	ITCH	98:101	PPAY	ITCH,NEDD4	0.9984	More...
Q9UPX0	Protein turtle homolog B	ITCH	925:928	PPAY	ITCH,NEDD4	0.9966	More...
Q9Y4P9	Sperm flagellar protein 1	ITCH	169:172	PPAY	ITCH,NEDD4	0.9985	More...
O15417	Trinucleotide repeat-containing gene 18 protein	ITCH	1018:1021	PPAY	ITCH,NEDD4	0.98	More...
P54792	Putative segment polarity protein dishevelled homolog DVL1P1	ITCH	525:528	PPAY	ITCH,NEDD4	0.9791	More...
Q8N0U2	Transmembrane protein 61	ITCH	147:150	PPAY	ITCH,NEDD4	0.7454	More...
Q9H0I9	Transketolase-like protein 2	ITCH	310:313	PPAY	ITCH,NEDD4	0.8808	More...
A6NMT0	Homeobox protein DBX1	ITCH	50:53	PPAY	ITCH,NEDD4	0.9932	More...
Q6UX72	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9	ITCH	65:68	PPAY	ITCH,NEDD4	0.8606	More...
Q6ZVC0	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1	ITCH	561:564	PPAY	ITCH,NEDD4	0.9991	More...
Q8IV13	Cyclin-J-like protein	ITCH	330:333	PPAY	ITCH,NEDD4	0.9938	More...
Q8N699	Myc target protein 1	ITCH	222:225	PPAY	ITCH,NEDD4	0.9901	More...
Q96G27	WW domain-binding protein 1	ITCH	124:127	PPAY	ITCH,NEDD4	0.9731	More...
Q9NWM3	CUE domain-containing protein 1	ITCH	133:136	PPAY	ITCH,NEDD4	0.993	More...
Q9ULL5	Proline-rich protein 12	ITCH	984:987	PPAY	ITCH,NEDD4	0.992	More...
A6NMB9	Fidgetin-like protein 2	ITCH	415:418	PPAY	ITCH,NEDD4	0.9107	More...
A8K5M9	Uncharacterized protein C15orf62, mitochondrial	ITCH	99:102	PPAY	ITCH,NEDD4	0.9174	More...
Q8N6L7	Transmembrane protein 252	ITCH	98:101	PPAY	ITCH,NEDD4	0.6068	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPAY

Degron related mutations and impact score

Drug responses associated with DVL1 mutations

All proteins holding degron of PPAY