DegronMD - Q8NFD5(ARID1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M1203I	TCGA-13-0903	OV	TCGA	PPTPAST	DEG_SCF_FBW7_1	1199:1205	Mutation altering degron motif	0.7618
p.M1203I	DO32616	OV	ICGC	PPTPAST	DEG_SCF_FBW7_1	1199:1205	Mutation altering degron motif	0.7618
p.G1208C	TCGA-43-2581	LUSC	TCGA	PPTPAST	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.25
p.G1208C	DO26602	LUSC	ICGC	PPTPAST	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.25
p.Q969H	TCGA-50-6590	LUAD	TCGA	NTQAPPYSMAP	CBL_PTK	978:988	Mutation rewiring degron network	0.0833
p.Q969H	DO24692	LUAD	ICGC	NTQAPPYSMAP	CBL_PTK	978:988	Mutation rewiring degron network	0.0833
p.P1183H	TCGA-55-6981	LUAD	TCGA	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation altering degron motif	0.7694
p.P1183H	DO24265	LUAD	ICGC	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation altering degron motif	0.7694
p.G1199A	TCGA-55-8089	LUAD	TCGA	PPTPAST	DEG_SCF_FBW7_1	1199:1205	Mutation altering degron motif	0.754
p.G1199A	DO23690	LUAD	ICGC	PPTPAST	DEG_SCF_FBW7_1	1199:1205	Mutation altering degron motif	0.754
p.G841S	TCGA-A5-A0G2	UCEC	TCGA	PPAY	ITCH	843:846	Mutation rewiring degron network	0.2778
p.G841S	TCGA-ZG-A9M4	PRAD	TCGA	PPAY	ITCH	843:846	Mutation rewiring degron network	0.2778
p.G841S	DO219442	PRAD	ICGC	PPAY	ITCH	843:846	Mutation rewiring degron network	0.2778
p.G841S	DO41235	UCEC	ICGC	PPAY	ITCH	843:846	Mutation rewiring degron network	0.2778
p.G841S	ACH-000718	Lung Cancer	CCLE	PPAY	ITCH	843:846	Mutation rewiring degron network	0.2778
p.G841S	NCI-H2291	lung	COSMIC	PPAY	ITCH	843:846	Mutation rewiring degron network	0.2778
p.P1176S	TCGA-A5-A0G2	UCEC	TCGA	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation rewiring degron network	0.25
p.P1176S	DO41235	UCEC	ICGC	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation rewiring degron network	0.25
p.A1184S	TCGA-A8-A09W	BRCA	TCGA	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation altering degron motif	0.7588
p.A1184S	DO1476	BRCA	ICGC	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation altering degron motif	0.7588
p.N984K	TCGA-AO-A0J2	BRCA	TCGA	NTQAPPYSMAP	CBL_PTK	978:988	Mutation altering degron motif	0.6918
p.N984K	DO2252	BRCA	ICGC	NTQAPPYSMAP	CBL_PTK	978:988	Mutation altering degron motif	0.6918
p.N984K	DO229045	LICA	ICGC	NTQAPPYSMAP	CBL_PTK	978:988	Mutation altering degron motif	0.6918
p.T992M	TCGA-AX-A1CE	UCEC	TCGA	NTQAPPYSMAP	CBL_PTK	978:988	Mutation rewiring degron network	0.2222
p.T992M	DO42280	UCEC	ICGC	NTQAPPYSMAP	CBL_PTK	978:988	Mutation rewiring degron network	0.2222
p.G572R	TCGA-B5-A3FC	UCEC	TCGA	PPQY	ITCH	581:584	Mutation rewiring degron network	0.0833
p.G572R	DO233118	GACA	ICGC	PPQY	ITCH	581:584	Mutation rewiring degron network	0.0833
p.G572R	DO41871	UCEC	ICGC	PPQY	ITCH	581:584	Mutation rewiring degron network	0.0833
p.N852K	TCGA-CV-5441	HNSC	TCGA	PPAY	ITCH	843:846	Mutation rewiring degron network	0.1667
p.N852K	DO15671	HNSC	ICGC	PPAY	ITCH	843:846	Mutation rewiring degron network	0.1667
p.G1112C	TCGA-D3-A2J6	SKCM	TCGA	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.1667
p.G1112C	DO37901	SKCM	ICGC	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.1667
p.P1195L	TCGA-D3-A8GM	SKCM	TCGA	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation rewiring degron network	0.0556
p.P1195L	TCGA-D3-A8GM	SKCM	TCGA	PPTPAST	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.2222
p.P1195L	DO50288	SKCM	ICGC	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation rewiring degron network	0.0556
p.P1195L	DO50288	SKCM	ICGC	PPTPAST	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.2222
p.N1119S	TCGA-DU-6392	LGG	TCGA	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation altering degron motif	0.7069
p.N1119S	DO22237	LGG	ICGC	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation altering degron motif	0.7069
p.S854F	TCGA-EE-A3AF	SKCM	TCGA	PPAY	ITCH	843:846	Mutation rewiring degron network	0.1111
p.S854F	DO37911	SKCM	ICGC	PPAY	ITCH	843:846	Mutation rewiring degron network	0.1111
p.L592F	TCGA-ER-A19P	SKCM	TCGA	PPQY	ITCH	581:584	Mutation rewiring degron network	0.1111
p.L592F	DO47623	SKCM	ICGC	PPQY	ITCH	581:584	Mutation rewiring degron network	0.1111
p.R525I	TCGA-EY-A1GI	UCEC	TCGA	KRPQLYGMG	DEG_APCC_DBOX_1	524:532	Mutation altering degron motif	0.8102
p.R525I	DO41211	UCEC	ICGC	KRPQLYGMG	DEG_APCC_DBOX_1	524:532	Mutation altering degron motif	0.8102
p.P576L	TCGA-HI-7168	PRAD	TCGA	PPQY	ITCH	581:584	Mutation rewiring degron network	0.1944
p.P576L	DO36229	PRAD	ICGC	PPQY	ITCH	581:584	Mutation rewiring degron network	0.1944
p.P1183T	TCGA-IB-7651	PAAD	TCGA	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation altering degron motif	0.7031
p.P1183T	DO46657	PAAD	ICGC	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation altering degron motif	0.7031
p.V522L	TCGA-L9-A444	LUAD	TCGA	KRPQLYGMG	DEG_APCC_DBOX_1	524:532	Mutation rewiring degron network	0.2778
p.V522L	DO26015	LUAD	ICGC	KRPQLYGMG	DEG_APCC_DBOX_1	524:532	Mutation rewiring degron network	0.2778
p.S845R	TCGA-OD-A75X	SKCM	TCGA	PPAY	ITCH	843:846	Mutation altering degron motif	0.7427
p.S845R	DO48601	SKCM	ICGC	PPAY	ITCH	843:846	Mutation altering degron motif	0.7427
p.Y997H	TCGA-QK-A652	HNSC	TCGA	NTQAPPYSMAP	CBL_PTK	978:988	Mutation rewiring degron network	0.0833
p.Y997H	DO49999	HNSC	ICGC	NTQAPPYSMAP	CBL_PTK	978:988	Mutation rewiring degron network	0.0833
p.Y997H	DO229257	THCA	ICGC	NTQAPPYSMAP	CBL_PTK	978:988	Mutation rewiring degron network	0.0833
p.Q541H	TCGA-VS-A9V1	CESC	TCGA	KRPQLYGMG	DEG_APCC_DBOX_1	524:532	Mutation rewiring degron network	0.0833
p.Q541H	DO51648	CESC	ICGC	KRPQLYGMG	DEG_APCC_DBOX_1	524:532	Mutation rewiring degron network	0.0833
p.Q843H	TCGA-XF-A8HD	BLCA	TCGA	PPAY	ITCH	843:846	Mutation altering degron motif	0.7582
p.Q843H	DO49795	BLCA	ICGC	PPAY	ITCH	843:846	Mutation altering degron motif	0.7582
p.E1124K	TCGA-ZF-AA51	BLCA	TCGA	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.2778
p.E1124K	DO219093	BLCA	ICGC	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.2778
p.Q494P	DO1020	BRCA	ICGC	PGTPGPT	DEG_SCF_FBW7_1	503:509	Mutation rewiring degron network	0.0833
p.K1177R	DO222700	BTCA	ICGC	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation rewiring degron network	0.2778
p.G532D	DO222817	BTCA	ICGC	KRPQLYGMG	DEG_APCC_DBOX_1	524:532	Mutation altering degron motif	0.6087
p.L1129R	DO234188	ESAD	ICGC	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation substituting flanking lysine	0.25
p.Q850H	DO234445	ESAD	ICGC	PPAY	ITCH	843:846	Mutation rewiring degron network	0.2222
p.G530D	DO233210	GACA	ICGC	KRPQLYGMG	DEG_APCC_DBOX_1	524:532	Mutation altering degron motif	0.6087
p.G532C	DO228922	LICA	ICGC	KRPQLYGMG	DEG_APCC_DBOX_1	524:532	Mutation altering degron motif	0.6489
p.M844R	DO228899	LICA	ICGC	PPAY	ITCH	843:846	Mutation altering degron motif	0.8632
p.G1187V	DO228985	LICA	ICGC	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation rewiring degron network	0.2778
p.G1187V	DO229028	LICA	ICGC	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation rewiring degron network	0.2778
p.W591L	DO229029	LICA	ICGC	PPQY	ITCH	581:584	Mutation rewiring degron network	0.1389
p.G572V	DO229031	LICA	ICGC	PPQY	ITCH	581:584	Mutation rewiring degron network	0.0833
p.G1111R	DO23338	LINC	ICGC	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.1389
p.G1111R	ACH-000449	Sarcoma	CCLE	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.1389
p.G1111R	MES-SA	soft tissue	COSMIC	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.1389
p.P842S	DO220891	MELA	ICGC	PPAY	ITCH	843:846	Mutation rewiring degron network	0.3056
p.G1112D	DO32887	PACA	ICGC	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.1667
p.Q833H	DO35239	PACA	ICGC	PPAY	ITCH	843:846	Mutation rewiring degron network	0.0556
p.S1202F	DO232224	PBCA	ICGC	PPTPAST	DEG_SCF_FBW7_1	1199:1205	Mutation altering degron motif	0.7982
p.L1129P	DO229459	SKCA	ICGC	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation substituting flanking lysine	0.25
p.A987V	SIDM02072	Colorectal Carcinoma	GDSC	NTQAPPYSMAP	CBL_PTK	978:988	Mutation altering degron motif	0.5825
p.Y1188C	SIDM01015	Chronic Myelogenous Leukemia	GDSC	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation rewiring degron network	0.25
p.Y1188C	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation rewiring degron network	0.25
p.G515A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	KRPQLYGMG	DEG_APCC_DBOX_1	524:532	Mutation rewiring degron network	0.0833
p.G515A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGTPGPT	DEG_SCF_FBW7_1	503:509	Mutation rewiring degron network	0.1667
p.G515A	HT	haematopoietic and lymphoid tissue	COSMIC	KRPQLYGMG	DEG_APCC_DBOX_1	524:532	Mutation rewiring degron network	0.0833
p.G515A	HT	haematopoietic and lymphoid tissue	COSMIC	PGTPGPT	DEG_SCF_FBW7_1	503:509	Mutation rewiring degron network	0.1667
p.S497N	SIDM00935	Other Solid Cancers	GDSC	PGTPGPT	DEG_SCF_FBW7_1	503:509	Mutation blocking phosphorylation signal	0.6111
p.S497N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PGTPGPT	DEG_SCF_FBW7_1	503:509	Mutation blocking phosphorylation signal	0.6111
p.S497N	ACH-002091	Skin Cancer	CCLE	PGTPGPT	DEG_SCF_FBW7_1	503:509	Mutation blocking phosphorylation signal	0.6111
p.S497N	ACH-002222	Leukemia	CCLE	PGTPGPT	DEG_SCF_FBW7_1	503:509	Mutation blocking phosphorylation signal	0.6111
p.S497N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PGTPGPT	DEG_SCF_FBW7_1	503:509	Mutation blocking phosphorylation signal	0.6111
p.S497N	CAL-39	vulva	COSMIC	PGTPGPT	DEG_SCF_FBW7_1	503:509	Mutation blocking phosphorylation signal	0.6111
p.V991L	SIDM00212	Glioblastoma	GDSC	NTQAPPYSMAP	CBL_PTK	978:988	Mutation rewiring degron network	0.25
p.V991L	CAS-1	central nervous system	COSMIC	NTQAPPYSMAP	CBL_PTK	978:988	Mutation rewiring degron network	0.25
p.P508S	SIDM00856	Other Solid Cancers	GDSC	PGTPGPT	DEG_SCF_FBW7_1	503:509	Mutation altering degron motif	0.5641
p.A996S	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	NTQAPPYSMAP	CBL_PTK	978:988	Mutation rewiring degron network	0.1111
p.A996S	NCI-H322M	lung	COSMIC	NTQAPPYSMAP	CBL_PTK	978:988	Mutation rewiring degron network	0.1111
p.P506L	SIDM00516	Melanoma	GDSC	PGTPGPT	DEG_SCF_FBW7_1	503:509	Mutation altering degron motif	0.7582
p.P506L	ACH-002166	Skin Cancer	CCLE	PGTPGPT	DEG_SCF_FBW7_1	503:509	Mutation altering degron motif	0.7582
p.P506L	MZ7-mel	skin	COSMIC	PGTPGPT	DEG_SCF_FBW7_1	503:509	Mutation altering degron motif	0.7582
p.A1132V	SIDM01088	Endometrial Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.0556
p.A1132V	RL95-2	endometrium	COSMIC	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.0556
p.V589A	SIDM00534	Colorectal Carcinoma	GDSC	PPQY	ITCH	581:584	Mutation rewiring degron network	0.1944
p.V589A	HT-115	large intestine	COSMIC	PPQY	ITCH	581:584	Mutation rewiring degron network	0.1944
p.P982S	SIDM01128	Small Cell Lung Carcinoma	GDSC	NTQAPPYSMAP	CBL_PTK	978:988	Mutation altering degron motif	0.5641
p.P982S	NCI-H526	lung	COSMIC	NTQAPPYSMAP	CBL_PTK	978:988	Mutation altering degron motif	0.5641
p.G856S	SIDM00479	Esophageal Carcinoma	GDSC	PPAY	ITCH	843:846	Mutation rewiring degron network	0.0556
p.D1114N	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation blocking phosphorylation signal	0.6667
p.D1114N	RC-K8	haematopoietic and lymphoid tissue	COSMIC	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation blocking phosphorylation signal	0.6667
p.L1130R	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation substituting flanking lysine	0.2222
p.L1130R	NCI-H3122	lung	COSMIC	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation substituting flanking lysine	0.2222
p.M580V	SIDM00901	Endometrial Carcinoma	GDSC	PPQY	ITCH	581:584	Mutation rewiring degron network	0.3056
p.M580V	AN3-CA	endometrium	COSMIC	PPQY	ITCH	581:584	Mutation rewiring degron network	0.3056
p.A981V	SIDM01608	Endometrial Carcinoma	GDSC	NTQAPPYSMAP	CBL_PTK	978:988	Mutation altering degron motif	0.5825
p.P988S	SIDM01608	Endometrial Carcinoma	GDSC	NTQAPPYSMAP	CBL_PTK	978:988	Mutation altering degron motif	0.6752
p.P995S	ACH-000767	Lung Cancer	CCLE	NTQAPPYSMAP	CBL_PTK	978:988	Mutation rewiring degron network	0.1389
p.P995S	NCI-H526	lung	COSMIC	NTQAPPYSMAP	CBL_PTK	978:988	Mutation rewiring degron network	0.1389
p.A994V	ACH-000990	Endometrial/Uterine Cancer	CCLE	NTQAPPYSMAP	CBL_PTK	978:988	Mutation rewiring degron network	0.1667
p.G1187E	ACH-001335	Cervical Cancer	CCLE	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation rewiring degron network	0.2778
p.A1200D	AGS	stomach	COSMIC	PPTPAST	DEG_SCF_FBW7_1	1199:1205	Mutation altering degron motif	0.7793
p.N1198S	NCI-H2347	lung	COSMIC	PPTPAST	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.3056
p.D1108N	NCI-H630	large intestine	COSMIC	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation substituting flanking lysine	0.1667
p.A1193D	AGS	stomach	COSMIC	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation rewiring degron network	0.1111
p.A1193D	AGS	stomach	COSMIC	PPTPAST	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.1667
p.M593V	AN3-CA	endometrium	COSMIC	PPQY	ITCH	581:584	Mutation rewiring degron network	0.0833
p.D1115N	NCI-H630	large intestine	COSMIC	VGTSS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.25
p.D1176A	NCI-H1876	lung	COSMIC	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation rewiring degron network	0.25
p.E1212K	SNU-1040	large intestine	COSMIC	PPTPAST	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.1389
p.Y572C	HT	haematopoietic and lymphoid tissue	COSMIC	PPQY	ITCH	581:584	Mutation rewiring degron network	0.0833
p.M1213V	42-MG-BA	central nervous system	COSMIC	PPTPAST	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.1111
p.N1191S	NCI-H2347	lung	COSMIC	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation rewiring degron network	0.1667
p.N1191S	NCI-H2347	lung	COSMIC	PPTPAST	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.1111
p.M516V	42-MG-BA	central nervous system	COSMIC	KRPQLYGMG	DEG_APCC_DBOX_1	524:532	Mutation blocking phosphorylation signal	0.5556
p.M516V	42-MG-BA	central nervous system	COSMIC	PGTPGPT	DEG_SCF_FBW7_1	503:509	Mutation blocking phosphorylation signal	0.5833
p.D1169A	NCI-H1876	lung	COSMIC	PQTPQST	DEG_SCF_FBW7_1	1179:1185	Mutation blocking phosphorylation signal	0.5

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARID1B

UniProt ID: Q8NFD5

Entrez ID: 57492

Protein name: AT-rich interactive domain-containing protein 1B (ARID domain-containing protein 1B) (BRG1-associated factor 250b) (BAF250B) (BRG1-binding protein hELD/OSA1) (Osa homolog 2) (hOsa2) (p250R)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARID1B in