DegronMD

Uniprot ID: Q8NFD5

Source protein: AT-rich interactive domain-containing protein 1B

Source gene: ARID1B

Class: ITCH

Location: 581:584

E3 ligase: ITCH,NEDD4

DEGRON score: 0.8798

ASA_SCORE: 96.75

COIL: 0.93

CONS_SCORE: 0.3298

DSS_SCORE: 0.5801

HELIX: 0.0513

FCONS_SCORE: 1.0303

RIG_SCORE: 0.6472

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G572R	TCGA-B5-A3FC	UCEC	TCGA	PPQY	ITCH	0.0833
p.G572R	DO233118	GACA	ICGC	PPQY	ITCH	0.0833
p.G572R	DO41871	UCEC	ICGC	PPQY	ITCH	0.0833
p.L592F	TCGA-ER-A19P	SKCM	TCGA	PPQY	ITCH	0.1111
p.L592F	DO47623	SKCM	ICGC	PPQY	ITCH	0.1111
p.P576L	TCGA-HI-7168	PRAD	TCGA	PPQY	ITCH	0.1944
p.P576L	DO36229	PRAD	ICGC	PPQY	ITCH	0.1944
p.W591L	DO229029	LICA	ICGC	PPQY	ITCH	0.1389
p.G572V	DO229031	LICA	ICGC	PPQY	ITCH	0.0833
p.V589A	SIDM00534	Colorectal Carcinoma	GDSC	PPQY	ITCH	0.1944
p.V589A	HT-115	large_intestine	COSMIC	PPQY	ITCH	0.1944
p.M580V	SIDM00901	Endometrial Carcinoma	GDSC	PPQY	ITCH	0.3056
p.M580V	AN3-CA	endometrium	COSMIC	PPQY	ITCH	0.3056
p.M593V	AN3-CA	endometrium	COSMIC	PPQY	ITCH	0.0833
p.Y572C	HT	haematopoietic_and_lymphoid_tissue	COSMIC	PPQY	ITCH	0.0833

Drug responses associated with ARID1B mutations

All proteins holding degron of PPQY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15162	Phospholipid scramblase 1	ITCH	22:25	PPQY	ITCH,NEDD4	0.9984	More...
O43809	Cleavage and polyadenylation specificity factor subunit 5	ITCH	155:158	PPQY	ITCH,NEDD4	0.5897	More...
O75791	GRB2-related adapter protein 2	ITCH	204:207	PPQY	ITCH,NEDD4	0.675	More...
P10153	Non-secretory ribonuclease	ITCH	147:150	PPQY	ITCH,NEDD4	0.8403	More...
P35680	Hepatocyte nuclear factor 1-beta	ITCH	519:522	PPQY	ITCH,NEDD4	0.9746	More...
P47902	Homeobox protein CDX-1	ITCH	39:42	PPQY	ITCH,NEDD4	0.9834	More...
Q15751	Probable E3 ubiquitin-protein ligase HERC1	ITCH	4383:4386	PPQY	ITCH,NEDD4	0.6066	More...
Q16650	T-box brain protein 1	ITCH	550:553	PPQY	ITCH,NEDD4	0.9804	More...
Q24JP5	Transmembrane protein 132A	ITCH	244:247	PPQY	ITCH,NEDD4	0.8056	More...
Q5JTH9	RRP12-like protein	ITCH	1209:1212	PPQY	ITCH,NEDD4	0.8336	More...
Q68CP9	AT-rich interactive domain-containing protein 2	ITCH	850:853	PPQY	ITCH,NEDD4	0.9824	More...
Q71SY5	Mediator of RNA polymerase II transcription subunit 25	ITCH	269:272	PPQY	ITCH,NEDD4	0.9206	More...
Q8IVH2	Forkhead box protein P4	ITCH	628:631	PPQY	ITCH,NEDD4	0.899	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	ITCH	581:584	PPQY	ITCH,NEDD4	0.8798	More...
Q8TB72	Pumilio homolog 2	ITCH	342:345	PPQY	ITCH,NEDD4	0.751	More...
Q92585	Mastermind-like protein 1	ITCH	670:673	PPQY	ITCH,NEDD4	0.9964	More...
Q96RT1	Erbin	ITCH	974:977	PPQY	ITCH,NEDD4	0.9986	More...
Q99626	Homeobox protein CDX-2	ITCH	34:37	PPQY	ITCH,NEDD4	0.7582	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	ITCH	951:954	PPQY	ITCH,NEDD4	0.9234	More...
Q9H7P6	Multivesicular body subunit 12B	ITCH	173:176	PPQY	ITCH,NEDD4	0.9906	More...
Q9NW97	Transmembrane protein 51	ITCH	236:239	PPQY	ITCH,NEDD4	0.9991	More...
Q9NZ53	Podocalyxin-like protein 2	ITCH	94:97	PPQY	ITCH,NEDD4	0.6559	More...
Q9P0N8	E3 ubiquitin-protein ligase MARCHF2	ITCH	33:36	PPQY	ITCH,NEDD4	0.7278	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	ITCH	587:590	PPQY	ITCH,NEDD4	0.9964	More...
Q9UPX0	Protein turtle homolog B	ITCH	145:148	PPQY	ITCH,NEDD4	0.7346	More...
Q9Y2J4	Angiomotin-like protein 2	ITCH	210:213	PPQY	ITCH,NEDD4	0.9661	More...
Q5T0L3	Spermatogenesis-associated protein 46	ITCH	53:56	PPQY	ITCH,NEDD4	0.9935	More...
Q86VI1	Exocyst complex component 3-like protein	ITCH	299:302	PPQY	ITCH,NEDD4	0.6459	More...
Q8WUU8	Transmembrane protein 174	ITCH	179:182	PPQY	ITCH,NEDD4	0.9754	More...
Q9ULL0	Acrosomal protein KIAA1210	ITCH	1154:1157	PPQY	ITCH,NEDD4	0.9027	More...
P0CJ78	Zinc finger protein 865	ITCH	74:77	PPQY	ITCH,NEDD4	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPQY

Degron related mutations and impact score

Drug responses associated with ARID1B mutations

All proteins holding degron of PPQY