DegronMD - Q86VI1(EXOC3L1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P299T	TCGA-BR-4370	STAD	TCGA	PPQY	ITCH	299:302	Mutation altering degron motif	0.7031
p.P299T	DO38499	STAD	ICGC	PPQY	ITCH	299:302	Mutation altering degron motif	0.7031
p.T311M	TCGA-D5-6924	COAD	TCGA	PPQY	ITCH	299:302	Mutation rewiring degron network	0.0833
p.T311M	DO7922	COAD	ICGC	PPQY	ITCH	299:302	Mutation rewiring degron network	0.0833
p.T311M	SIDM00220	Ovarian Carcinoma	GDSC	PPQY	ITCH	299:302	Mutation rewiring degron network	0.0833
p.T311M	ACH-000962	Ovarian Cancer	CCLE	PPQY	ITCH	299:302	Mutation rewiring degron network	0.0833
p.T311M	ACH-001145	Ovarian Cancer	CCLE	PPQY	ITCH	299:302	Mutation rewiring degron network	0.0833
p.T311M	OC-314	ovary	COSMIC	PPQY	ITCH	299:302	Mutation rewiring degron network	0.0833
p.L293V	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PPQY	ITCH	299:302	Mutation rewiring degron network	0.1667
p.L293V	ACH-000983	Leukemia	CCLE	PPQY	ITCH	299:302	Mutation rewiring degron network	0.1667
p.L293V	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PPQY	ITCH	299:302	Mutation rewiring degron network	0.1667
p.C297R	SIDM01609	Endometrial Carcinoma	GDSC	PPQY	ITCH	299:302	Mutation rewiring degron network	0.2778
p.C297R	ACH-000972	Endometrial/Uterine Cancer	CCLE	PPQY	ITCH	299:302	Mutation rewiring degron network	0.2778
p.H310Y	SIDM01624	Bladder Carcinoma	GDSC	PPQY	ITCH	299:302	Mutation rewiring degron network	0.1111
p.H310Y	SIDM01529	Bladder Carcinoma	GDSC	PPQY	ITCH	299:302	Mutation rewiring degron network	0.1111
p.H310Y	ACH-000011	Bladder Cancer	CCLE	PPQY	ITCH	299:302	Mutation rewiring degron network	0.1111
p.H310Y	ACH-000026	Bladder Cancer	CCLE	PPQY	ITCH	299:302	Mutation rewiring degron network	0.1111
p.C297Y	ACH-001737	Leukemia	CCLE	PPQY	ITCH	299:302	Mutation rewiring degron network	0.2778

Kaplan plot for EXOC3L1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EXOC3L1

UniProt ID: Q86VI1

Entrez ID: 283849

Protein name: Exocyst complex component 3-like protein (Protein Jiangli)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EXOC3L1 in