DegronMD

Uniprot ID: Q86VI1

Source protein: Exocyst complex component 3-like protein

Source gene: EXOC3L1

Class: ITCH

Location: 299:302

E3 ligase: ITCH,NEDD4

DEGRON score: 0.6459

ASA_SCORE: 73.5

COIL: 0.813

CONS_SCORE: 0.6771

DSS_SCORE: 0.0477

HELIX: 0.1748

FCONS_SCORE: 1.2193

RIG_SCORE: 0.8304

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P299T	TCGA-BR-4370	STAD	TCGA	PPQY	ITCH	0.7031
p.P299T	DO38499	STAD	ICGC	PPQY	ITCH	0.7031
p.C297R	SIDM01609	Endometrial Carcinoma	GDSC	PPQY	ITCH	0.2778
p.C297R	ACH-000972	Endometrial/Uterine Cancer	CCLE	PPQY	ITCH	0.2778
p.C297Y	ACH-001737	Leukemia	CCLE	PPQY	ITCH	0.2778
p.L293V	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PPQY	ITCH	0.1667
p.L293V	ACH-000983	Leukemia	CCLE	PPQY	ITCH	0.1667
p.L293V	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PPQY	ITCH	0.1667
p.H310Y	SIDM01624	Bladder Carcinoma	GDSC	PPQY	ITCH	0.1111
p.H310Y	SIDM01529	Bladder Carcinoma	GDSC	PPQY	ITCH	0.1111
p.H310Y	ACH-000011	Bladder Cancer	CCLE	PPQY	ITCH	0.1111
p.H310Y	ACH-000026	Bladder Cancer	CCLE	PPQY	ITCH	0.1111
p.T311M	TCGA-D5-6924	COAD	TCGA	PPQY	ITCH	0.0833
p.T311M	DO7922	COAD	ICGC	PPQY	ITCH	0.0833
p.T311M	SIDM00220	Ovarian Carcinoma	GDSC	PPQY	ITCH	0.0833
p.T311M	ACH-000962	Ovarian Cancer	CCLE	PPQY	ITCH	0.0833
p.T311M	ACH-001145	Ovarian Cancer	CCLE	PPQY	ITCH	0.0833
p.T311M	OC-314	ovary	COSMIC	PPQY	ITCH	0.0833

Showing 1 to 18 of 18 entries

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Drug responses associated with EXOC3L1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPQY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULL0	Acrosomal protein KIAA1210	ITCH	1154:1157	PPQY	ITCH,NEDD4	0.9027	More...
Q9Y2J4	Angiomotin-like protein 2	ITCH	210:213	PPQY	ITCH,NEDD4	0.9661	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	ITCH	581:584	PPQY	ITCH,NEDD4	0.8798	More...
Q68CP9	AT-rich interactive domain-containing protein 2	ITCH	850:853	PPQY	ITCH,NEDD4	0.9824	More...
O43809	Cleavage and polyadenylation specificity factor subunit 5	ITCH	155:158	PPQY	ITCH,NEDD4	0.5897	More...
Q9P0N8	E3 ubiquitin-protein ligase MARCHF2	ITCH	33:36	PPQY	ITCH,NEDD4	0.7278	More...
Q96RT1	Erbin	ITCH	974:977	PPQY	ITCH,NEDD4	0.9986	More...
Q86VI1	Exocyst complex component 3-like protein	ITCH	299:302	PPQY	ITCH,NEDD4	0.6459	More...
Q8IVH2	Forkhead box protein P4	ITCH	628:631	PPQY	ITCH,NEDD4	0.899	More...
O75791	GRB2-related adapter protein 2	ITCH	204:207	PPQY	ITCH,NEDD4	0.675	More...
P35680	Hepatocyte nuclear factor 1-beta	ITCH	519:522	PPQY	ITCH,NEDD4	0.9746	More...
P47902	Homeobox protein CDX-1	ITCH	39:42	PPQY	ITCH,NEDD4	0.9834	More...
Q99626	Homeobox protein CDX-2	ITCH	34:37	PPQY	ITCH,NEDD4	0.7582	More...
Q92585	Mastermind-like protein 1	ITCH	670:673	PPQY	ITCH,NEDD4	0.9964	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	ITCH	587:590	PPQY	ITCH,NEDD4	0.9964	More...
Q71SY5	Mediator of RNA polymerase II transcription subunit 25	ITCH	269:272	PPQY	ITCH,NEDD4	0.9206	More...
Q9H7P6	Multivesicular body subunit 12B	ITCH	173:176	PPQY	ITCH,NEDD4	0.9906	More...
P10153	Non-secretory ribonuclease	ITCH	147:150	PPQY	ITCH,NEDD4	0.8403	More...
O15162	Phospholipid scramblase 1	ITCH	22:25	PPQY	ITCH,NEDD4	0.9984	More...
Q9NZ53	Podocalyxin-like protein 2	ITCH	94:97	PPQY	ITCH,NEDD4	0.6559	More...
Q15751	Probable E3 ubiquitin-protein ligase HERC1	ITCH	4383:4386	PPQY	ITCH,NEDD4	0.6066	More...
Q9UPX0	Protein turtle homolog B	ITCH	145:148	PPQY	ITCH,NEDD4	0.7346	More...
Q8TB72	Pumilio homolog 2	ITCH	342:345	PPQY	ITCH,NEDD4	0.751	More...
Q5JTH9	RRP12-like protein	ITCH	1209:1212	PPQY	ITCH,NEDD4	0.8336	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	ITCH	951:954	PPQY	ITCH,NEDD4	0.9234	More...

Showing 1 to 25 of 31 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPQY

Degron related mutations and impact score

Drug responses associated with EXOC3L1 mutations

All proteins holding degron of PPQY