DegronMD

Uniprot ID: P10153

Source protein: Non-secretory ribonuclease

Source gene: RNASE2

Class: ITCH

Location: 147:150

E3 ligase: ITCH,NEDD4

DEGRON score: 0.8403

ASA_SCORE: 79.825

COIL: 0.8743

CONS_SCORE: 0.7535

DSS_SCORE: 0.4651

HELIX: 0.0528

FCONS_SCORE: 1.0076

RIG_SCORE: 0.7063

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P147H	TCGA-12-0820	GBM	TCGA	PPQY	ITCH	0.7694
p.P147H	DO12838	GBM	ICGC	PPQY	ITCH	0.7694
p.I160M	TCGA-22-4595	LUSC	TCGA	PPQY	ITCH	0.0556
p.I160M	DO26641	LUSC	ICGC	PPQY	ITCH	0.0556
p.P151L	TCGA-A5-A0G2	UCEC	TCGA	PPQY	ITCH	0.3056
p.P151L	DO41235	UCEC	ICGC	PPQY	ITCH	0.3056
p.R159I	TCGA-AP-A1DV	UCEC	TCGA	PPQY	ITCH	0.0833
p.R159I	DO43186	UCEC	ICGC	PPQY	ITCH	0.0833
p.R145Q	TCGA-DX-A7ET	SARC	TCGA	PPQY	ITCH	0.2778
p.R145Q	TCGA-Z2-A8RT	SKCM	TCGA	PPQY	ITCH	0.2778
p.R145Q	DO220038	SARC	ICGC	PPQY	ITCH	0.2778
p.R145Q	DO51301	SKCM	ICGC	PPQY	ITCH	0.2778
p.R141I	TCGA-E6-A1LX	UCEC	TCGA	PPQY	ITCH	0.1667
p.R141I	DO41020	UCEC	ICGC	PPQY	ITCH	0.1667
p.D142Y	TCGA-E6-A1LX	UCEC	TCGA	PPQY	ITCH	0.1944
p.D142Y	DO41020	UCEC	ICGC	PPQY	ITCH	0.1944
p.P151T	TCGA-WK-A8Y0	SARC	TCGA	PPQY	ITCH	0.3056
p.P151T	DO220305	SARC	ICGC	PPQY	ITCH	0.3056
p.R145L	DO229015	LICA	ICGC	PPQY	ITCH	0.2778
p.Q143H	DO222494	MELA	ICGC	PPQY	ITCH	0.2222
p.R144P	SIDM01199	Hepatocellular Carcinoma	GDSC	PPQY	ITCH	0.25
p.R144P	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PPQY	ITCH	0.25
p.D139V	ACH-000773	Lymphoma	CCLE	PPQY	ITCH	0.1111

Drug responses associated with RNASE2 mutations

All proteins holding degron of PPQY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15162	Phospholipid scramblase 1	ITCH	22:25	PPQY	ITCH,NEDD4	0.9984	More...
O43809	Cleavage and polyadenylation specificity factor subunit 5	ITCH	155:158	PPQY	ITCH,NEDD4	0.5897	More...
O75791	GRB2-related adapter protein 2	ITCH	204:207	PPQY	ITCH,NEDD4	0.675	More...
P10153	Non-secretory ribonuclease	ITCH	147:150	PPQY	ITCH,NEDD4	0.8403	More...
P35680	Hepatocyte nuclear factor 1-beta	ITCH	519:522	PPQY	ITCH,NEDD4	0.9746	More...
P47902	Homeobox protein CDX-1	ITCH	39:42	PPQY	ITCH,NEDD4	0.9834	More...
Q15751	Probable E3 ubiquitin-protein ligase HERC1	ITCH	4383:4386	PPQY	ITCH,NEDD4	0.6066	More...
Q16650	T-box brain protein 1	ITCH	550:553	PPQY	ITCH,NEDD4	0.9804	More...
Q24JP5	Transmembrane protein 132A	ITCH	244:247	PPQY	ITCH,NEDD4	0.8056	More...
Q5JTH9	RRP12-like protein	ITCH	1209:1212	PPQY	ITCH,NEDD4	0.8336	More...
Q68CP9	AT-rich interactive domain-containing protein 2	ITCH	850:853	PPQY	ITCH,NEDD4	0.9824	More...
Q71SY5	Mediator of RNA polymerase II transcription subunit 25	ITCH	269:272	PPQY	ITCH,NEDD4	0.9206	More...
Q8IVH2	Forkhead box protein P4	ITCH	628:631	PPQY	ITCH,NEDD4	0.899	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	ITCH	581:584	PPQY	ITCH,NEDD4	0.8798	More...
Q8TB72	Pumilio homolog 2	ITCH	342:345	PPQY	ITCH,NEDD4	0.751	More...
Q92585	Mastermind-like protein 1	ITCH	670:673	PPQY	ITCH,NEDD4	0.9964	More...
Q96RT1	Erbin	ITCH	974:977	PPQY	ITCH,NEDD4	0.9986	More...
Q99626	Homeobox protein CDX-2	ITCH	34:37	PPQY	ITCH,NEDD4	0.7582	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	ITCH	951:954	PPQY	ITCH,NEDD4	0.9234	More...
Q9H7P6	Multivesicular body subunit 12B	ITCH	173:176	PPQY	ITCH,NEDD4	0.9906	More...
Q9NW97	Transmembrane protein 51	ITCH	236:239	PPQY	ITCH,NEDD4	0.9991	More...
Q9NZ53	Podocalyxin-like protein 2	ITCH	94:97	PPQY	ITCH,NEDD4	0.6559	More...
Q9P0N8	E3 ubiquitin-protein ligase MARCHF2	ITCH	33:36	PPQY	ITCH,NEDD4	0.7278	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	ITCH	587:590	PPQY	ITCH,NEDD4	0.9964	More...
Q9UPX0	Protein turtle homolog B	ITCH	145:148	PPQY	ITCH,NEDD4	0.7346	More...
Q9Y2J4	Angiomotin-like protein 2	ITCH	210:213	PPQY	ITCH,NEDD4	0.9661	More...
Q5T0L3	Spermatogenesis-associated protein 46	ITCH	53:56	PPQY	ITCH,NEDD4	0.9935	More...
Q86VI1	Exocyst complex component 3-like protein	ITCH	299:302	PPQY	ITCH,NEDD4	0.6459	More...
Q8WUU8	Transmembrane protein 174	ITCH	179:182	PPQY	ITCH,NEDD4	0.9754	More...
Q9ULL0	Acrosomal protein KIAA1210	ITCH	1154:1157	PPQY	ITCH,NEDD4	0.9027	More...
P0CJ78	Zinc finger protein 865	ITCH	74:77	PPQY	ITCH,NEDD4	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPQY

Degron related mutations and impact score

Drug responses associated with RNASE2 mutations

All proteins holding degron of PPQY