DegronMD - Q9NW97(TMEM51)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V137G	TCGA-A5-A0G1	UCEC	TCGA	DEEAASRYYVPSY	DEG_COP1_1	122:134	Mutation rewiring degron network	0.25
p.V137G	DO42472	UCEC	ICGC	DEEAASRYYVPSY	DEG_COP1_1	122:134	Mutation rewiring degron network	0.25
p.P235S	TCGA-A5-A0G1	UCEC	TCGA	PPQY	ITCH	236:239	Mutation rewiring degron network	0.3056
p.P235S	DO42472	UCEC	ICGC	PPQY	ITCH	236:239	Mutation rewiring degron network	0.3056
p.A126V	TCGA-A5-A0G2	UCEC	TCGA	DEEAASRYYVPSY	DEG_COP1_1	122:134	Mutation altering degron motif	0.5825
p.A126V	DO41235	UCEC	ICGC	DEEAASRYYVPSY	DEG_COP1_1	122:134	Mutation altering degron motif	0.5825
p.P237L	TCGA-A5-A0G2	UCEC	TCGA	PPQY	ITCH	236:239	Mutation altering degron motif	0.7582
p.P237L	DO41235	UCEC	ICGC	PPQY	ITCH	236:239	Mutation altering degron motif	0.7582
p.P228H	TCGA-A6-3809	COAD	TCGA	PPQY	ITCH	236:239	Mutation rewiring degron network	0.1111
p.P228H	DO8722	COAD	ICGC	PPQY	ITCH	236:239	Mutation rewiring degron network	0.1111
p.P232H	TCGA-B5-A11E	UCEC	TCGA	PPQY	ITCH	236:239	Mutation rewiring degron network	0.2222
p.P232H	DO41644	UCEC	ICGC	PPQY	ITCH	236:239	Mutation rewiring degron network	0.2222
p.P232H	SIDM00217	Colorectal Carcinoma	GDSC	PPQY	ITCH	236:239	Mutation rewiring degron network	0.2222
p.P232H	ACH-000999	Colon/Colorectal Cancer	CCLE	PPQY	ITCH	236:239	Mutation rewiring degron network	0.2222
p.P232H	SNU-1040	large intestine	COSMIC	PPQY	ITCH	236:239	Mutation rewiring degron network	0.2222
p.N141Y	TCGA-KN-8432	KICH	TCGA	DEEAASRYYVPSY	DEG_COP1_1	122:134	Mutation rewiring degron network	0.1389
p.N141Y	DO220510	KICH	ICGC	DEEAASRYYVPSY	DEG_COP1_1	122:134	Mutation rewiring degron network	0.1389
p.E120K	TCGA-LT-A5Z6	BLCA	TCGA	DEEAASRYYVPSY	DEG_COP1_1	122:134	Mutation rewiring degron network	0.2778
p.E120K	DO44029	BLCA	ICGC	DEEAASRYYVPSY	DEG_COP1_1	122:134	Mutation rewiring degron network	0.2778
p.P236S	TCGA-QB-AA9O	SKCM	TCGA	PPQY	ITCH	236:239	Mutation altering degron motif	0.6752
p.P236S	DO51267	SKCM	ICGC	PPQY	ITCH	236:239	Mutation altering degron motif	0.6752
p.E241K	TCGA-ZJ-AAXU	CESC	TCGA	PPQY	ITCH	236:239	Mutation rewiring degron network	0.2778
p.E241K	DO219759	CESC	ICGC	PPQY	ITCH	236:239	Mutation rewiring degron network	0.2778
p.T133M	DO234322	ESAD	ICGC	DEEAASRYYVPSY	DEG_COP1_1	122:134	Mutation altering degron motif	0.7423
p.D240N	DO233779	GACA	ICGC	PPQY	ITCH	236:239	Mutation rewiring degron network	0.3056
p.D240G	DO233941	GACA	ICGC	PPQY	ITCH	236:239	Mutation rewiring degron network	0.3056
p.P131Q	DO20786	KIRP	ICGC	DEEAASRYYVPSY	DEG_COP1_1	122:134	Mutation altering degron motif	0.7035
p.S115G	DO229208	THCA	ICGC	DEEAASRYYVPSY	DEG_COP1_1	122:134	Mutation blocking phosphorylation signal	0.5833
p.P226H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPQY	ITCH	236:239	Mutation rewiring degron network	0.0556
p.P226H	ACH-000981	Leukemia	CCLE	PPQY	ITCH	236:239	Mutation rewiring degron network	0.0556
p.P226H	DND-41	haematopoietic and lymphoid tissue	COSMIC	PPQY	ITCH	236:239	Mutation rewiring degron network	0.0556
p.E135D	SIDM00572	Gastric Carcinoma	GDSC	DEEAASRYYVPSY	DEG_COP1_1	122:134	Mutation rewiring degron network	0.3056
p.E135D	ACH-000911	Gastric Cancer	CCLE	DEEAASRYYVPSY	DEG_COP1_1	122:134	Mutation rewiring degron network	0.3056
p.E135D	NUGC-3	stomach	COSMIC	DEEAASRYYVPSY	DEG_COP1_1	122:134	Mutation rewiring degron network	0.3056
p.D248N	SIDM00928	Breast Carcinoma	GDSC	PPQY	ITCH	236:239	Mutation rewiring degron network	0.0833
p.D248N	CAL-85-1	breast	COSMIC	PPQY	ITCH	236:239	Mutation rewiring degron network	0.0833
p.E135K	SIDM01619	Endometrial Carcinoma	GDSC	DEEAASRYYVPSY	DEG_COP1_1	122:134	Mutation rewiring degron network	0.3056
p.E135K	ACH-000984	Endometrial/Uterine Cancer	CCLE	DEEAASRYYVPSY	DEG_COP1_1	122:134	Mutation rewiring degron network	0.3056
p.R134M	NUGC-3	stomach	COSMIC	DEEAASRYYVPSY	DEG_COP1_1	122:134	Mutation altering degron motif	0.8632

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM51

UniProt ID: Q9NW97

Entrez ID: 55092

Protein name: Transmembrane protein 51

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM51 in