DegronMD

Uniprot ID: Q9NW97

Source protein: Transmembrane protein 51

Source gene: TMEM51

Class: DEG_COP1_1

Location: 122:134

E3 ligase: COP1

DEGRON score: 0.993

ASA_SCORE: 80.3692

COIL: 0.5152

CONS_SCORE: 0.7442

DSS_SCORE: 0.6862

HELIX: 0.3638

FCONS_SCORE: 1.2112

RIG_SCORE: 0.7138

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V137G	TCGA-A5-A0G1	UCEC	TCGA	DEEAASRYYVPSY	DEG_COP1_1	0.25
p.V137G	DO42472	UCEC	ICGC	DEEAASRYYVPSY	DEG_COP1_1	0.25
p.A126V	TCGA-A5-A0G2	UCEC	TCGA	DEEAASRYYVPSY	DEG_COP1_1	0.5825
p.A126V	DO41235	UCEC	ICGC	DEEAASRYYVPSY	DEG_COP1_1	0.5825
p.N141Y	TCGA-KN-8432	KICH	TCGA	DEEAASRYYVPSY	DEG_COP1_1	0.1389
p.N141Y	DO220510	KICH	ICGC	DEEAASRYYVPSY	DEG_COP1_1	0.1389
p.E120K	TCGA-LT-A5Z6	BLCA	TCGA	DEEAASRYYVPSY	DEG_COP1_1	0.2778
p.E120K	DO44029	BLCA	ICGC	DEEAASRYYVPSY	DEG_COP1_1	0.2778
p.T133M	DO234322	ESAD	ICGC	DEEAASRYYVPSY	DEG_COP1_1	0.7423
p.P131Q	DO20786	KIRP	ICGC	DEEAASRYYVPSY	DEG_COP1_1	0.7035
p.S115G	DO229208	THCA	ICGC	DEEAASRYYVPSY	DEG_COP1_1	0.5833
p.E135D	SIDM00572	Gastric Carcinoma	GDSC	DEEAASRYYVPSY	DEG_COP1_1	0.3056
p.E135D	ACH-000911	Gastric Cancer	CCLE	DEEAASRYYVPSY	DEG_COP1_1	0.3056
p.E135D	NUGC-3	stomach	COSMIC	DEEAASRYYVPSY	DEG_COP1_1	0.3056
p.E135K	SIDM01619	Endometrial Carcinoma	GDSC	DEEAASRYYVPSY	DEG_COP1_1	0.3056
p.E135K	ACH-000984	Endometrial/Uterine Cancer	CCLE	DEEAASRYYVPSY	DEG_COP1_1	0.3056
p.R134M	NUGC-3	stomach	COSMIC	DEEAASRYYVPSY	DEG_COP1_1	0.8632

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NW97	Transmembrane protein 51	DEG_COP1_1	122:134	DEEAASRYYVPSY	COP1	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons