DegronMD - O75791(GRAP2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q203P	TCGA-41-2575	GBM	TCGA	PPQY	ITCH	204:207	Mutation rewiring degron network	0.3056
p.H198N	TCGA-BG-A222	UCEC	TCGA	PPQY	ITCH	204:207	Mutation rewiring degron network	0.1667
p.A208V	TCGA-DK-A6AW	BLCA	TCGA	PPQY	ITCH	204:207	Mutation rewiring degron network	0.3056
p.H198Q	TCGA-EO-A22T	UCEC	TCGA	PPQY	ITCH	204:207	Mutation rewiring degron network	0.1667
p.H198Q	SIDM00498	Colorectal Carcinoma	GDSC	PPQY	ITCH	204:207	Mutation rewiring degron network	0.1667
p.H198Q	ACH-000970	Colon/Colorectal Cancer	CCLE	PPQY	ITCH	204:207	Mutation rewiring degron network	0.1667
p.Q206H	TCGA-FS-A1ZW	SKCM	TCGA	PPQY	ITCH	204:207	Mutation altering degron motif	0.647
p.Q206H	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	PPQY	ITCH	204:207	Mutation altering degron motif	0.647
p.Q206H	ACH-000488	Esophageal Cancer	CCLE	PPQY	ITCH	204:207	Mutation altering degron motif	0.647
p.A210G	DO6152	BRCA	ICGC	PPQY	ITCH	204:207	Mutation rewiring degron network	0.25
p.R211Q	DO6260	CESC	ICGC	PPQY	ITCH	204:207	Mutation rewiring degron network	0.2222
p.R211Q	DO233820	GACA	ICGC	PPQY	ITCH	204:207	Mutation rewiring degron network	0.2222
p.W209C	DO228948	LICA	ICGC	PPQY	ITCH	204:207	Mutation rewiring degron network	0.2778
p.V199L	DO229028	LICA	ICGC	PPQY	ITCH	204:207	Mutation rewiring degron network	0.1944
p.R208Q	DO44876	LIHC	ICGC	PPQY	ITCH	204:207	Mutation rewiring degron network	0.3056
p.V199G	DO27699	LUSC	ICGC	PPQY	ITCH	204:207	Mutation rewiring degron network	0.1944
p.T196A	DO35442	PACA	ICGC	PPQY	ITCH	204:207	Mutation rewiring degron network	0.1111
p.A212V	DO47873	STAD	ICGC	PPQY	ITCH	204:207	Mutation rewiring degron network	0.1944
p.A212V	DO41235	UCEC	ICGC	PPQY	ITCH	204:207	Mutation rewiring degron network	0.1944
p.D197Y	DO42472	UCEC	ICGC	PPQY	ITCH	204:207	Mutation rewiring degron network	0.1389
p.P211L	ACH-001521	Skin Cancer	CCLE	PPQY	ITCH	204:207	Mutation rewiring degron network	0.2222

Kaplan plot for GRAP2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRAP2

UniProt ID: O75791

Entrez ID: 9402

Protein name: GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for GRAP2 in