DegronMD

Uniprot ID: O75791

Source protein: GRB2-related adapter protein 2

Source gene: GRAP2

Class: ITCH

Location: 204:207

E3 ligase: ITCH,NEDD4

DEGRON score: 0.675

ASA_SCORE: 82.6

COIL: 0.8383

CONS_SCORE: 0.4961

DSS_SCORE: 0.9356

HELIX: 0.0552

FCONS_SCORE: 0.9897

RIG_SCORE: 0.5461

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q203P	TCGA-41-2575	GBM	TCGA	PPQY	ITCH	0.3056
p.H198N	TCGA-BG-A222	UCEC	TCGA	PPQY	ITCH	0.1667
p.A208V	TCGA-DK-A6AW	BLCA	TCGA	PPQY	ITCH	0.3056
p.H198Q	TCGA-EO-A22T	UCEC	TCGA	PPQY	ITCH	0.1667
p.H198Q	SIDM00498	Colorectal Carcinoma	GDSC	PPQY	ITCH	0.1667
p.H198Q	ACH-000970	Colon/Colorectal Cancer	CCLE	PPQY	ITCH	0.1667
p.Q206H	TCGA-FS-A1ZW	SKCM	TCGA	PPQY	ITCH	0.647
p.Q206H	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	PPQY	ITCH	0.647
p.Q206H	ACH-000488	Esophageal Cancer	CCLE	PPQY	ITCH	0.647
p.A210G	DO6152	BRCA	ICGC	PPQY	ITCH	0.25
p.R211Q	DO6260	CESC	ICGC	PPQY	ITCH	0.2222
p.R211Q	DO233820	GACA	ICGC	PPQY	ITCH	0.2222
p.W209C	DO228948	LICA	ICGC	PPQY	ITCH	0.2778
p.V199L	DO229028	LICA	ICGC	PPQY	ITCH	0.1944
p.R208Q	DO44876	LIHC	ICGC	PPQY	ITCH	0.3056
p.V199G	DO27699	LUSC	ICGC	PPQY	ITCH	0.1944
p.T196A	DO35442	PACA	ICGC	PPQY	ITCH	0.1111
p.A212V	DO47873	STAD	ICGC	PPQY	ITCH	0.1944
p.A212V	DO41235	UCEC	ICGC	PPQY	ITCH	0.1944
p.D197Y	DO42472	UCEC	ICGC	PPQY	ITCH	0.1389
p.P211L	ACH-001521	Skin Cancer	CCLE	PPQY	ITCH	0.2222

Drug responses associated with GRAP2 mutations

All proteins holding degron of PPQY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15162	Phospholipid scramblase 1	ITCH	22:25	PPQY	ITCH,NEDD4	0.9984	More...
O43809	Cleavage and polyadenylation specificity factor subunit 5	ITCH	155:158	PPQY	ITCH,NEDD4	0.5897	More...
O75791	GRB2-related adapter protein 2	ITCH	204:207	PPQY	ITCH,NEDD4	0.675	More...
P10153	Non-secretory ribonuclease	ITCH	147:150	PPQY	ITCH,NEDD4	0.8403	More...
P35680	Hepatocyte nuclear factor 1-beta	ITCH	519:522	PPQY	ITCH,NEDD4	0.9746	More...
P47902	Homeobox protein CDX-1	ITCH	39:42	PPQY	ITCH,NEDD4	0.9834	More...
Q15751	Probable E3 ubiquitin-protein ligase HERC1	ITCH	4383:4386	PPQY	ITCH,NEDD4	0.6066	More...
Q16650	T-box brain protein 1	ITCH	550:553	PPQY	ITCH,NEDD4	0.9804	More...
Q24JP5	Transmembrane protein 132A	ITCH	244:247	PPQY	ITCH,NEDD4	0.8056	More...
Q5JTH9	RRP12-like protein	ITCH	1209:1212	PPQY	ITCH,NEDD4	0.8336	More...
Q68CP9	AT-rich interactive domain-containing protein 2	ITCH	850:853	PPQY	ITCH,NEDD4	0.9824	More...
Q71SY5	Mediator of RNA polymerase II transcription subunit 25	ITCH	269:272	PPQY	ITCH,NEDD4	0.9206	More...
Q8IVH2	Forkhead box protein P4	ITCH	628:631	PPQY	ITCH,NEDD4	0.899	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	ITCH	581:584	PPQY	ITCH,NEDD4	0.8798	More...
Q8TB72	Pumilio homolog 2	ITCH	342:345	PPQY	ITCH,NEDD4	0.751	More...
Q92585	Mastermind-like protein 1	ITCH	670:673	PPQY	ITCH,NEDD4	0.9964	More...
Q96RT1	Erbin	ITCH	974:977	PPQY	ITCH,NEDD4	0.9986	More...
Q99626	Homeobox protein CDX-2	ITCH	34:37	PPQY	ITCH,NEDD4	0.7582	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	ITCH	951:954	PPQY	ITCH,NEDD4	0.9234	More...
Q9H7P6	Multivesicular body subunit 12B	ITCH	173:176	PPQY	ITCH,NEDD4	0.9906	More...
Q9NW97	Transmembrane protein 51	ITCH	236:239	PPQY	ITCH,NEDD4	0.9991	More...
Q9NZ53	Podocalyxin-like protein 2	ITCH	94:97	PPQY	ITCH,NEDD4	0.6559	More...
Q9P0N8	E3 ubiquitin-protein ligase MARCHF2	ITCH	33:36	PPQY	ITCH,NEDD4	0.7278	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	ITCH	587:590	PPQY	ITCH,NEDD4	0.9964	More...
Q9UPX0	Protein turtle homolog B	ITCH	145:148	PPQY	ITCH,NEDD4	0.7346	More...
Q9Y2J4	Angiomotin-like protein 2	ITCH	210:213	PPQY	ITCH,NEDD4	0.9661	More...
Q5T0L3	Spermatogenesis-associated protein 46	ITCH	53:56	PPQY	ITCH,NEDD4	0.9935	More...
Q86VI1	Exocyst complex component 3-like protein	ITCH	299:302	PPQY	ITCH,NEDD4	0.6459	More...
Q8WUU8	Transmembrane protein 174	ITCH	179:182	PPQY	ITCH,NEDD4	0.9754	More...
Q9ULL0	Acrosomal protein KIAA1210	ITCH	1154:1157	PPQY	ITCH,NEDD4	0.9027	More...
P0CJ78	Zinc finger protein 865	ITCH	74:77	PPQY	ITCH,NEDD4	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPQY

Degron related mutations and impact score

Drug responses associated with GRAP2 mutations

All proteins holding degron of PPQY