DegronMD

Uniprot ID: Q5JTH9

Source protein: RRP12-like protein

Source gene: RRP12

Class: ITCH

Location: 1209:1212

E3 ligase: ITCH,NEDD4

DEGRON score: 0.8336

ASA_SCORE: 94.55

COIL: 0.7435

CONS_SCORE: 0.2218

DSS_SCORE: 0.6167

HELIX: 0.2385

FCONS_SCORE: 0.6061

RIG_SCORE: 0.7002

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1221C	TCGA-24-1845	OV	TCGA	PPQY	ITCH	0.0833
p.R1221C	DO29920	OV	ICGC	PPQY	ITCH	0.0833
p.E1204K	TCGA-CR-6472	HNSC	TCGA	PPQY	ITCH	0.1944
p.E1204K	TCGA-QK-A64Z	HNSC	TCGA	PPQY	ITCH	0.1944
p.E1204K	DO15870	HNSC	ICGC	PPQY	ITCH	0.1944
p.E1204K	DO49053	HNSC	ICGC	PPQY	ITCH	0.1944
p.E1204D	TCGA-EE-A181	SKCM	TCGA	PPQY	ITCH	0.1944
p.E1204D	DO37444	SKCM	ICGC	PPQY	ITCH	0.1944
p.R1221H	TCGA-EO-A22R	UCEC	TCGA	PPQY	ITCH	0.0833
p.R1221H	DO42713	UCEC	ICGC	PPQY	ITCH	0.0833
p.P1209S	TCGA-Y8-A894	KIRP	TCGA	PPQY	ITCH	0.6752
p.P1209S	DO49798	KIRP	ICGC	PPQY	ITCH	0.6752
p.P1222L	DO50437	ESAD	ICGC	PPQY	ITCH	0.0556
p.S1217F	DO228947	LICA	ICGC	PPQY	ITCH	0.6389
p.I1219V	DO234007	THCA	ICGC	PPQY	ITCH	0.1389
p.Q1211H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPQY	ITCH	0.647
p.Q1211H	ACH-000995	Leukemia	CCLE	PPQY	ITCH	0.647
p.P1210T	SIDM00657	Acute Myeloid Leukemia	GDSC	PPQY	ITCH	0.7031
p.P1210T	ACH-000045	Leukemia	CCLE	PPQY	ITCH	0.7031
p.P1210T	MV-4-11	haematopoietic_and_lymphoid_tissue	COSMIC	PPQY	ITCH	0.7031
p.P1210S	SIDM00612	Glioma	GDSC	PPQY	ITCH	0.6752
p.P1210S	ACH-002257	Brain Cancer	CCLE	PPQY	ITCH	0.6752
p.P1210S	KINGS-1	central_nervous_system	COSMIC	PPQY	ITCH	0.6752
p.R1202H	SNG-M	endometrium	COSMIC	PPQY	ITCH	0.1389
p.R1202C	SNU-1040	large_intestine	COSMIC	PPQY	ITCH	0.1389
p.G1214V	COR-L32	lung	COSMIC	PPQY	ITCH	0.2778
p.K1205N	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	PPQY	ITCH	0.2222

Drug responses associated with RRP12 mutations

All proteins holding degron of PPQY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15162	Phospholipid scramblase 1	ITCH	22:25	PPQY	ITCH,NEDD4	0.9984	More...
O43809	Cleavage and polyadenylation specificity factor subunit 5	ITCH	155:158	PPQY	ITCH,NEDD4	0.5897	More...
O75791	GRB2-related adapter protein 2	ITCH	204:207	PPQY	ITCH,NEDD4	0.675	More...
P10153	Non-secretory ribonuclease	ITCH	147:150	PPQY	ITCH,NEDD4	0.8403	More...
P35680	Hepatocyte nuclear factor 1-beta	ITCH	519:522	PPQY	ITCH,NEDD4	0.9746	More...
P47902	Homeobox protein CDX-1	ITCH	39:42	PPQY	ITCH,NEDD4	0.9834	More...
Q15751	Probable E3 ubiquitin-protein ligase HERC1	ITCH	4383:4386	PPQY	ITCH,NEDD4	0.6066	More...
Q16650	T-box brain protein 1	ITCH	550:553	PPQY	ITCH,NEDD4	0.9804	More...
Q24JP5	Transmembrane protein 132A	ITCH	244:247	PPQY	ITCH,NEDD4	0.8056	More...
Q5JTH9	RRP12-like protein	ITCH	1209:1212	PPQY	ITCH,NEDD4	0.8336	More...
Q68CP9	AT-rich interactive domain-containing protein 2	ITCH	850:853	PPQY	ITCH,NEDD4	0.9824	More...
Q71SY5	Mediator of RNA polymerase II transcription subunit 25	ITCH	269:272	PPQY	ITCH,NEDD4	0.9206	More...
Q8IVH2	Forkhead box protein P4	ITCH	628:631	PPQY	ITCH,NEDD4	0.899	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	ITCH	581:584	PPQY	ITCH,NEDD4	0.8798	More...
Q8TB72	Pumilio homolog 2	ITCH	342:345	PPQY	ITCH,NEDD4	0.751	More...
Q92585	Mastermind-like protein 1	ITCH	670:673	PPQY	ITCH,NEDD4	0.9964	More...
Q96RT1	Erbin	ITCH	974:977	PPQY	ITCH,NEDD4	0.9986	More...
Q99626	Homeobox protein CDX-2	ITCH	34:37	PPQY	ITCH,NEDD4	0.7582	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	ITCH	951:954	PPQY	ITCH,NEDD4	0.9234	More...
Q9H7P6	Multivesicular body subunit 12B	ITCH	173:176	PPQY	ITCH,NEDD4	0.9906	More...
Q9NW97	Transmembrane protein 51	ITCH	236:239	PPQY	ITCH,NEDD4	0.9991	More...
Q9NZ53	Podocalyxin-like protein 2	ITCH	94:97	PPQY	ITCH,NEDD4	0.6559	More...
Q9P0N8	E3 ubiquitin-protein ligase MARCHF2	ITCH	33:36	PPQY	ITCH,NEDD4	0.7278	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	ITCH	587:590	PPQY	ITCH,NEDD4	0.9964	More...
Q9UPX0	Protein turtle homolog B	ITCH	145:148	PPQY	ITCH,NEDD4	0.7346	More...
Q9Y2J4	Angiomotin-like protein 2	ITCH	210:213	PPQY	ITCH,NEDD4	0.9661	More...
Q5T0L3	Spermatogenesis-associated protein 46	ITCH	53:56	PPQY	ITCH,NEDD4	0.9935	More...
Q86VI1	Exocyst complex component 3-like protein	ITCH	299:302	PPQY	ITCH,NEDD4	0.6459	More...
Q8WUU8	Transmembrane protein 174	ITCH	179:182	PPQY	ITCH,NEDD4	0.9754	More...
Q9ULL0	Acrosomal protein KIAA1210	ITCH	1154:1157	PPQY	ITCH,NEDD4	0.9027	More...
P0CJ78	Zinc finger protein 865	ITCH	74:77	PPQY	ITCH,NEDD4	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPQY

Degron related mutations and impact score

Drug responses associated with RRP12 mutations

All proteins holding degron of PPQY