DegronMD - Q9NZ53(PODXL2)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M239I	TCGA-66-2758	LUSC	TCGA	DSGDQAS	DEG_SCF_TRCP1_1	224:230	Mutation rewiring degron network	0.0833
p.M239I	DO26731	LUSC	ICGC	DSGDQAS	DEG_SCF_TRCP1_1	224:230	Mutation rewiring degron network	0.0833
p.R90Q	TCGA-AA-A022	COAD	TCGA	PPQY	ITCH	94:97	Mutation rewiring degron network	0.2222
p.R90Q	TCGA-DI-A2QT	UCEC	TCGA	PPQY	ITCH	94:97	Mutation rewiring degron network	0.2222
p.R90Q	DO10647	COAD	ICGC	PPQY	ITCH	94:97	Mutation rewiring degron network	0.2222
p.R90Q	DO233902	GACA	ICGC	PPQY	ITCH	94:97	Mutation rewiring degron network	0.2222
p.R90Q	DO41692	UCEC	ICGC	PPQY	ITCH	94:97	Mutation rewiring degron network	0.2222
p.G232D	TCGA-AP-A051	UCEC	TCGA	DSGDQAS	DEG_SCF_TRCP1_1	224:230	Mutation rewiring degron network	0.2778
p.G232D	DO42673	UCEC	ICGC	DSGDQAS	DEG_SCF_TRCP1_1	224:230	Mutation rewiring degron network	0.2778
p.H222Q	TCGA-RC-A6M6	LIHC	TCGA	DSGDQAS	DEG_SCF_TRCP1_1	224:230	Mutation rewiring degron network	0.2778
p.H222Q	DO223917	LIHC	ICGC	DSGDQAS	DEG_SCF_TRCP1_1	224:230	Mutation rewiring degron network	0.2778
p.M239V	DO233193	GACA	ICGC	DSGDQAS	DEG_SCF_TRCP1_1	224:230	Mutation rewiring degron network	0.0833
p.G226R	SIDM01156	Small Cell Lung Carcinoma	GDSC	DSGDQAS	DEG_SCF_TRCP1_1	224:230	Mutation altering degron motif	0.7568
p.P215S	SIDM01133	Other Solid Cancers	GDSC	DSGDQAS	DEG_SCF_TRCP1_1	224:230	Mutation rewiring degron network	0.0833
p.P215S	ACH-002177	Lung Cancer	CCLE	DSGDQAS	DEG_SCF_TRCP1_1	224:230	Mutation rewiring degron network	0.0833
p.P215S	NCI-H835	lung	COSMIC	DSGDQAS	DEG_SCF_TRCP1_1	224:230	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons