DegronMD

Uniprot ID: Q9NZ53

Source protein: Podocalyxin-like protein 2

Source gene: PODXL2

Class: DEG_SCF_TRCP1_1

Location: 224:230

E3 ligase: BTRC

DEGRON score: 0.9994

ASA_SCORE: 80.5571

COIL: 0.8746

CONS_SCORE: 0.6075

DSS_SCORE: 0.7362

HELIX: 0.0913

FCONS_SCORE: 1.2637

RIG_SCORE: 0.5712

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M239I	TCGA-66-2758	LUSC	TCGA	DSGDQAS	DEG_SCF_TRCP1_1	0.0833
p.M239I	DO26731	LUSC	ICGC	DSGDQAS	DEG_SCF_TRCP1_1	0.0833
p.G232D	TCGA-AP-A051	UCEC	TCGA	DSGDQAS	DEG_SCF_TRCP1_1	0.2778
p.G232D	DO42673	UCEC	ICGC	DSGDQAS	DEG_SCF_TRCP1_1	0.2778
p.H222Q	TCGA-RC-A6M6	LIHC	TCGA	DSGDQAS	DEG_SCF_TRCP1_1	0.2778
p.H222Q	DO223917	LIHC	ICGC	DSGDQAS	DEG_SCF_TRCP1_1	0.2778
p.M239V	DO233193	GACA	ICGC	DSGDQAS	DEG_SCF_TRCP1_1	0.0833
p.G226R	SIDM01156	Small Cell Lung Carcinoma	GDSC	DSGDQAS	DEG_SCF_TRCP1_1	0.7568
p.P215S	SIDM01133	Other Solid Cancers	GDSC	DSGDQAS	DEG_SCF_TRCP1_1	0.0833
p.P215S	ACH-002177	Lung Cancer	CCLE	DSGDQAS	DEG_SCF_TRCP1_1	0.0833
p.P215S	NCI-H835	lung	COSMIC	DSGDQAS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZ53	Podocalyxin-like protein 2	DEG_SCF_TRCP1_1	224:230	DSGDQAS	BTRC	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons