DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPQY
Uniprot ID:
O15162
Source protein:
Phospholipid scramblase 1
Source gene:
PLSCR1
Class:
ITCH
Location:
22:25
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9984
ASA_SCORE:
79.25
COIL:
0.9605
CONS_SCORE:
0.5674
DSS_SCORE:
0.661
HELIX:
0.01
FCONS_SCORE:
1.1723
RIG_SCORE:
0.6246
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P27L
TCGA-55-7907
LUAD
TCGA
PPQY
ITCH
0.2778
p.P27L
SIDM02041
Colorectal Carcinoma
GDSC
PPQY
ITCH
0.2778
p.P23A
TCGA-61-1740
OV
TCGA
PPQY
ITCH
0.7503
p.P23R
TCGA-CR-6491
HNSC
TCGA
PPQY
ITCH
0.7512
p.F30L
TCGA-CX-7082
HNSC
TCGA
PPQY
ITCH
0.1944
p.Q31R
TCGA-D1-A103
UCEC
TCGA
PPQY
ITCH
0.1667
p.H12N
TCGA-G2-A2EK
BLCA
TCGA
PPQY
ITCH
0.0556
p.H12N
TCGA-XF-A9SY
BLCA
TCGA
PPQY
ITCH
0.0556
p.G32E
TCGA-YC-A89H
BLCA
TCGA
PPQY
ITCH
0.1389
p.N16H
TCGA-Z6-A8JD
ESCA
TCGA
PPQY
ITCH
0.1667
p.Y21C
TCGA-ZQ-A9CR
STAD
TCGA
PPQY
ITCH
0.3056
p.G25E
DO51948
BLCA
ICGC
PPQY
ITCH
0.7199
p.F23L
DO14268
HNSC
ICGC
PPQY
ITCH
0.6981
p.P16R
DO14192
HNSC
ICGC
PPQY
ITCH
0.1667
p.T21K
DO228986
LICA
ICGC
PPQY
ITCH
0.3056
p.T21K
DO229025
LICA
ICGC
PPQY
ITCH
0.3056
p.P15T
DO229031
LICA
ICGC
PPQY
ITCH
0.1389
p.P19T
DO229034
LICA
ICGC
PPQY
ITCH
0.25
p.P20T
DO229036
LICA
ICGC
PPQY
ITCH
0.2778
p.G28V
DO24566
LUAD
ICGC
PPQY
ITCH
0.25
p.P16A
DO27981
OV
ICGC
PPQY
ITCH
0.1667
p.Y14C
DO50145
STAD
ICGC
PPQY
ITCH
0.1111
p.Q24R
DO42312
UCEC
ICGC
PPQY
ITCH
0.6218
p.G20V
SIDM00672
Hepatocellular Carcinoma
GDSC
PPQY
ITCH
0.2778
p.G20V
SIDM01090
Colorectal Carcinoma
GDSC
PPQY
ITCH
0.2778
p.G20V
SIDM00954
Breast Carcinoma
GDSC
PPQY
ITCH
0.2778
p.Y21H
SIDM01608
Endometrial Carcinoma
GDSC
PPQY
ITCH
0.3056
p.Y21H
ACH-000990
Endometrial/Uterine Cancer
CCLE
PPQY
ITCH
0.3056
p.A29S
ACH-000999
Colon/Colorectal Cancer
CCLE
PPQY
ITCH
0.2222
p.A29S
SNU-1040
large_intestine
COSMIC
PPQY
ITCH
0.2222
p.A22S
SNU-1040
large_intestine
COSMIC
PPQY
ITCH
0.7588
p.D25N
LNCaP-Clone-FGC
prostate
COSMIC
PPQY
ITCH
0.6932
p.Q20H
SNU-1040
large_intestine
COSMIC
PPQY
ITCH
0.2778
Drug responses associated with PLSCR1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPQY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15162
Phospholipid scramblase 1
ITCH
22:25
PPQY
ITCH,NEDD4
0.9984
More...
O43809
Cleavage and polyadenylation specificity factor subunit 5
ITCH
155:158
PPQY
ITCH,NEDD4
0.5897
More...
O75791
GRB2-related adapter protein 2
ITCH
204:207
PPQY
ITCH,NEDD4
0.675
More...
P10153
Non-secretory ribonuclease
ITCH
147:150
PPQY
ITCH,NEDD4
0.8403
More...
P35680
Hepatocyte nuclear factor 1-beta
ITCH
519:522
PPQY
ITCH,NEDD4
0.9746
More...
P47902
Homeobox protein CDX-1
ITCH
39:42
PPQY
ITCH,NEDD4
0.9834
More...
Q15751
Probable E3 ubiquitin-protein ligase HERC1
ITCH
4383:4386
PPQY
ITCH,NEDD4
0.6066
More...
Q16650
T-box brain protein 1
ITCH
550:553
PPQY
ITCH,NEDD4
0.9804
More...
Q24JP5
Transmembrane protein 132A
ITCH
244:247
PPQY
ITCH,NEDD4
0.8056
More...
Q5JTH9
RRP12-like protein
ITCH
1209:1212
PPQY
ITCH,NEDD4
0.8336
More...
Q68CP9
AT-rich interactive domain-containing protein 2
ITCH
850:853
PPQY
ITCH,NEDD4
0.9824
More...
Q71SY5
Mediator of RNA polymerase II transcription subunit 25
ITCH
269:272
PPQY
ITCH,NEDD4
0.9206
More...
Q8IVH2
Forkhead box protein P4
ITCH
628:631
PPQY
ITCH,NEDD4
0.899
More...
Q8NFD5
AT-rich interactive domain-containing protein 1B
ITCH
581:584
PPQY
ITCH,NEDD4
0.8798
More...
Q8TB72
Pumilio homolog 2
ITCH
342:345
PPQY
ITCH,NEDD4
0.751
More...
Q92585
Mastermind-like protein 1
ITCH
670:673
PPQY
ITCH,NEDD4
0.9964
More...
Q96RT1
Erbin
ITCH
974:977
PPQY
ITCH,NEDD4
0.9986
More...
Q99626
Homeobox protein CDX-2
ITCH
34:37
PPQY
ITCH,NEDD4
0.7582
More...
Q9H4A3
Serine/threonine-protein kinase WNK1
ITCH
951:954
PPQY
ITCH,NEDD4
0.9234
More...
Q9H7P6
Multivesicular body subunit 12B
ITCH
173:176
PPQY
ITCH,NEDD4
0.9906
More...
Q9NW97
Transmembrane protein 51
ITCH
236:239
PPQY
ITCH,NEDD4
0.9991
More...
Q9NZ53
Podocalyxin-like protein 2
ITCH
94:97
PPQY
ITCH,NEDD4
0.6559
More...
Q9P0N8
E3 ubiquitin-protein ligase MARCHF2
ITCH
33:36
PPQY
ITCH,NEDD4
0.7278
More...
Q9UHV7
Mediator of RNA polymerase II transcription subunit 13
ITCH
587:590
PPQY
ITCH,NEDD4
0.9964
More...
Q9UPX0
Protein turtle homolog B
ITCH
145:148
PPQY
ITCH,NEDD4
0.7346
More...
Q9Y2J4
Angiomotin-like protein 2
ITCH
210:213
PPQY
ITCH,NEDD4
0.9661
More...
Q5T0L3
Spermatogenesis-associated protein 46
ITCH
53:56
PPQY
ITCH,NEDD4
0.9935
More...
Q86VI1
Exocyst complex component 3-like protein
ITCH
299:302
PPQY
ITCH,NEDD4
0.6459
More...
Q8WUU8
Transmembrane protein 174
ITCH
179:182
PPQY
ITCH,NEDD4
0.9754
More...
Q9ULL0
Acrosomal protein KIAA1210
ITCH
1154:1157
PPQY
ITCH,NEDD4
0.9027
More...
P0CJ78
Zinc finger protein 865
ITCH
74:77
PPQY
ITCH,NEDD4
0.9965
More...