DegronMD - Q24JP5(TMEM132A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D243Y	TCGA-55-8207	LUAD	TCGA	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.0556
p.D243Y	TCGA-55-8207	LUAD	TCGA	PPQY	ITCH	244:247	Mutation rewiring degron network	0.3056
p.D243Y	DO45351	LUAD	ICGC	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.0556
p.D243Y	DO45351	LUAD	ICGC	PPQY	ITCH	244:247	Mutation rewiring degron network	0.3056
p.R266W	TCGA-A6-5661	COAD	TCGA	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.25
p.R266W	DO8634	COAD	ICGC	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.25
p.R266L	TCGA-AA-3715	COAD	TCGA	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.25
p.R266L	DO8018	COAD	ICGC	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.25
p.R266Q	TCGA-AZ-4315	COAD	TCGA	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.25
p.R266Q	TCGA-GF-A3OT	SKCM	TCGA	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.25
p.R266Q	DO8842	COAD	ICGC	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.25
p.R266Q	DO47288	SKCM	ICGC	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.25
p.P251L	TCGA-FW-A3R5	SKCM	TCGA	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.2778
p.P251L	TCGA-FW-A3R5	SKCM	TCGA	PPQY	ITCH	244:247	Mutation rewiring degron network	0.2222
p.P251L	TCGA-GN-A8LK	SKCM	TCGA	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.2778
p.P251L	TCGA-GN-A8LK	SKCM	TCGA	PPQY	ITCH	244:247	Mutation rewiring degron network	0.2222
p.P251L	DO37406	SKCM	ICGC	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.2778
p.P251L	DO37406	SKCM	ICGC	PPQY	ITCH	244:247	Mutation rewiring degron network	0.2222
p.P251L	DO51259	SKCM	ICGC	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.2778
p.P251L	DO51259	SKCM	ICGC	PPQY	ITCH	244:247	Mutation rewiring degron network	0.2222
p.R240H	DO233271	GACA	ICGC	PPQY	ITCH	244:247	Mutation rewiring degron network	0.2222
p.A273G	DO228301	LICA	ICGC	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.0556
p.R240L	DO229025	LICA	ICGC	PPQY	ITCH	244:247	Mutation rewiring degron network	0.2222
p.P264S	DO23543	LIRI	ICGC	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.3056
p.R240C	DO228355	MALY	ICGC	PPQY	ITCH	244:247	Mutation rewiring degron network	0.2222
p.D253N	DO222837	MELA	ICGC	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation altering degron motif	0.6932
p.E249K	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.2222
p.E249K	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PPQY	ITCH	244:247	Mutation rewiring degron network	0.2778
p.E249K	ACH-000823	Esophageal Cancer	CCLE	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.2222
p.E249K	ACH-000823	Esophageal Cancer	CCLE	PPQY	ITCH	244:247	Mutation rewiring degron network	0.2778
p.E249K	KYSE-140	oesophagus	COSMIC	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.2222
p.E249K	KYSE-140	oesophagus	COSMIC	PPQY	ITCH	244:247	Mutation rewiring degron network	0.2778
p.A242V	SIDM00537	Colorectal Carcinoma	GDSC	PPQY	ITCH	244:247	Mutation rewiring degron network	0.2778
p.A242V	ACH-000982	Colon/Colorectal Cancer	CCLE	PPQY	ITCH	244:247	Mutation rewiring degron network	0.2778
p.A242V	ACH-001345	Colon/Colorectal Cancer	CCLE	PPQY	ITCH	244:247	Mutation rewiring degron network	0.2778
p.A242V	GP5d	large intestine	COSMIC	PPQY	ITCH	244:247	Mutation rewiring degron network	0.2778
p.G268S	ACH-000451	Lung Cancer	CCLE	DEAVTLRVPDM	DEG_COP1_1	253:263	Mutation rewiring degron network	0.1944

Kaplan plot for TMEM132A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM132A

UniProt ID: Q24JP5

Entrez ID: 54972

Protein name: Transmembrane protein 132A (HSPA5-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM132A in