DegronMD

Uniprot ID: Q24JP5

Source protein: Transmembrane protein 132A

Source gene: TMEM132A

Class: DEG_COP1_1

Location: 253:263

E3 ligase: COP1

DEGRON score: 0.8793

ASA_SCORE: 51

COIL: 0.5947

CONS_SCORE: 0.8006

DSS_SCORE: 0.4031

HELIX: 0.0297

FCONS_SCORE: 1.0008

RIG_SCORE: 0.8027

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D243Y	TCGA-55-8207	LUAD	TCGA	DEAVTLRVPDM	DEG_COP1_1	0.0556
p.D243Y	DO45351	LUAD	ICGC	DEAVTLRVPDM	DEG_COP1_1	0.0556
p.R266W	TCGA-A6-5661	COAD	TCGA	DEAVTLRVPDM	DEG_COP1_1	0.25
p.R266W	DO8634	COAD	ICGC	DEAVTLRVPDM	DEG_COP1_1	0.25
p.R266L	TCGA-AA-3715	COAD	TCGA	DEAVTLRVPDM	DEG_COP1_1	0.25
p.R266L	DO8018	COAD	ICGC	DEAVTLRVPDM	DEG_COP1_1	0.25
p.R266Q	TCGA-AZ-4315	COAD	TCGA	DEAVTLRVPDM	DEG_COP1_1	0.25
p.R266Q	TCGA-GF-A3OT	SKCM	TCGA	DEAVTLRVPDM	DEG_COP1_1	0.25
p.R266Q	DO8842	COAD	ICGC	DEAVTLRVPDM	DEG_COP1_1	0.25
p.R266Q	DO47288	SKCM	ICGC	DEAVTLRVPDM	DEG_COP1_1	0.25
p.P251L	TCGA-FW-A3R5	SKCM	TCGA	DEAVTLRVPDM	DEG_COP1_1	0.2778
p.P251L	TCGA-GN-A8LK	SKCM	TCGA	DEAVTLRVPDM	DEG_COP1_1	0.2778
p.P251L	DO37406	SKCM	ICGC	DEAVTLRVPDM	DEG_COP1_1	0.2778
p.P251L	DO51259	SKCM	ICGC	DEAVTLRVPDM	DEG_COP1_1	0.2778
p.A273G	DO228301	LICA	ICGC	DEAVTLRVPDM	DEG_COP1_1	0.0556
p.P264S	DO23543	LIRI	ICGC	DEAVTLRVPDM	DEG_COP1_1	0.3056
p.D253N	DO222837	MELA	ICGC	DEAVTLRVPDM	DEG_COP1_1	0.6932
p.E249K	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	DEAVTLRVPDM	DEG_COP1_1	0.2222
p.E249K	ACH-000823	Esophageal Cancer	CCLE	DEAVTLRVPDM	DEG_COP1_1	0.2222
p.E249K	KYSE-140	oesophagus	COSMIC	DEAVTLRVPDM	DEG_COP1_1	0.2222
p.G268S	ACH-000451	Lung Cancer	CCLE	DEAVTLRVPDM	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q24JP5	Transmembrane protein 132A	DEG_COP1_1	253:263	DEAVTLRVPDM	COP1	0.8793	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons