DegronMD - Q16650(TBR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S91Y	TCGA-06-5416	GBM	TCGA	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation blocking phosphorylation signal	0.6667
p.S91Y	DO10880	GBM	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation blocking phosphorylation signal	0.6667
p.E649K	TCGA-55-A48Y	LUAD	TCGA	PADTPVSE	DEG_SCF_FBW7_2	642:649	Mutation altering degron motif	0.7022
p.P69T	TCGA-86-8358	LUAD	TCGA	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0556
p.P69T	DO25471	LUAD	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0556
p.T645M	TCGA-AU-6004	COAD	TCGA	PADTPVSE	DEG_SCF_FBW7_2	642:649	Mutation altering degron motif	0.7423
p.P69L	TCGA-BT-A3PK	BLCA	TCGA	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0556
p.P69L	DO44051	BLCA	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0556
p.P85L	TCGA-CV-7099	HNSC	TCGA	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation altering degron motif	0.6471
p.P85L	DO15294	HNSC	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation altering degron motif	0.6471
p.R94H	TCGA-D1-A1NY	UCEC	TCGA	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1389
p.R94H	DO42512	UCEC	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1389
p.R94C	TCGA-D8-A1J8	BRCA	TCGA	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1389
p.R94C	DO1269	BRCA	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1389
p.D70Y	TCGA-EE-A182	SKCM	TCGA	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0833
p.D70Y	DO228948	LICA	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0833
p.D70Y	DO37814	SKCM	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0833
p.D70Y	SIDM00847	Rhabdomyosarcoma	GDSC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0833
p.D70Y	ACH-000169	Sarcoma	CCLE	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0833
p.D70Y	RD	soft tissue	COSMIC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0833
p.P653Q	TCGA-ER-A19P	SKCM	TCGA	PADTPVSE	DEG_SCF_FBW7_2	642:649	Mutation rewiring degron network	0.2222
p.E649G	TCGA-JY-A6FH	ESCA	TCGA	PADTPVSE	DEG_SCF_FBW7_2	642:649	Mutation altering degron motif	0.7199
p.D73N	TCGA-MI-A75I	LIHC	TCGA	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1667
p.D73N	DO49712	LIHC	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1667
p.D77G	DO222501	COCA	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.2778
p.V82I	DO234462	ESAD	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation altering degron motif	0.7076
p.V82I	DO233823	GACA	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation altering degron motif	0.7076
p.A84V	DO26502	LUSC	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation altering degron motif	0.6936
p.I90M	DO27011	LUSC	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.25
p.H97Y	DO220877	MELA	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0556
p.G89E	DO222843	MELA	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.2778
p.T88M	DO47889	STAD	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.3056
p.Q86H	DO42793	UCEC	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation altering degron motif	0.7582
p.V69M	DO42713	UCEC	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0556
p.V69M	COLO-741	large intestine	COSMIC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0556
p.A643V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PADTPVSE	DEG_SCF_FBW7_2	642:649	Mutation altering degron motif	0.5825
p.S651L	SIDM01175	Other Sarcomas	GDSC	PADTPVSE	DEG_SCF_FBW7_2	642:649	Mutation rewiring degron network	0.2778
p.S651L	ACH-002309	Sarcoma	CCLE	PADTPVSE	DEG_SCF_FBW7_2	642:649	Mutation rewiring degron network	0.2778
p.D644E	SIDM01041	Esophageal Carcinoma	GDSC	PADTPVSE	DEG_SCF_FBW7_2	642:649	Mutation altering degron motif	0.5647
p.D644E	FLO-1	oesophagus	COSMIC	PADTPVSE	DEG_SCF_FBW7_2	642:649	Mutation altering degron motif	0.5647
p.S96R	SIDM00233	T-Lymphoblastic Leukemia	GDSC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0833
p.S96R	ACH-002058	Leukemia	CCLE	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0833
p.S96R	ATN-1	haematopoietic and lymphoid tissue	COSMIC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0833
p.V658M	SIDM00316	Glioblastoma	GDSC	PADTPVSE	DEG_SCF_FBW7_2	642:649	Mutation rewiring degron network	0.0833
p.V658M	ACH-000469	Brain Cancer	CCLE	PADTPVSE	DEG_SCF_FBW7_2	642:649	Mutation rewiring degron network	0.0833
p.V658M	YH-13	central nervous system	COSMIC	PADTPVSE	DEG_SCF_FBW7_2	642:649	Mutation rewiring degron network	0.0833
p.P550S	ACH-000668	Breast Cancer	CCLE	PPQY	ITCH	550:553	Mutation altering degron motif	0.6752
p.P551T	ACH-000958	Colon/Colorectal Cancer	CCLE	PPQY	ITCH	550:553	Mutation altering degron motif	0.7031
p.D88G	ACH-001610	Brain Cancer	CCLE	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.3056
p.T73I	COR-L95	lung	COSMIC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1667
p.T77P	NCI-H510A	lung	COSMIC	QRSKLSPVL	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.2778

Kaplan plot for TBR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TBR1

UniProt ID: Q16650

Entrez ID: 10716

Protein name: T-box brain protein 1 (T-brain-1) (TBR-1) (TES-56)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TBR1 in