DegronMD

Uniprot ID: Q16650

Source protein: T-box brain protein 1

Source gene: TBR1

Class: DEG_APCC_DBOX_1

Location: 79:87

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8274

ASA_SCORE: 86.4778

COIL: 0.787

CONS_SCORE: 0.5356

DSS_SCORE: 0.5967

HELIX: 0.143

FCONS_SCORE: 0.7278

RIG_SCORE: 0.6919

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S91Y	TCGA-06-5416	GBM	TCGA	QRSKLSPVL	DEG_APCC_DBOX_1	0.6667
p.S91Y	DO10880	GBM	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.6667
p.P69T	TCGA-86-8358	LUAD	TCGA	QRSKLSPVL	DEG_APCC_DBOX_1	0.0556
p.P69T	DO25471	LUAD	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.0556
p.P69L	TCGA-BT-A3PK	BLCA	TCGA	QRSKLSPVL	DEG_APCC_DBOX_1	0.0556
p.P69L	DO44051	BLCA	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.0556
p.P85L	TCGA-CV-7099	HNSC	TCGA	QRSKLSPVL	DEG_APCC_DBOX_1	0.6471
p.P85L	DO15294	HNSC	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.6471
p.R94H	TCGA-D1-A1NY	UCEC	TCGA	QRSKLSPVL	DEG_APCC_DBOX_1	0.1389
p.R94H	DO42512	UCEC	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.1389
p.R94C	TCGA-D8-A1J8	BRCA	TCGA	QRSKLSPVL	DEG_APCC_DBOX_1	0.1389
p.R94C	DO1269	BRCA	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.1389
p.D70Y	TCGA-EE-A182	SKCM	TCGA	QRSKLSPVL	DEG_APCC_DBOX_1	0.0833
p.D70Y	DO228948	LICA	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.0833
p.D70Y	DO37814	SKCM	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.0833
p.D70Y	SIDM00847	Rhabdomyosarcoma	GDSC	QRSKLSPVL	DEG_APCC_DBOX_1	0.0833
p.D70Y	ACH-000169	Sarcoma	CCLE	QRSKLSPVL	DEG_APCC_DBOX_1	0.0833
p.D70Y	RD	soft_tissue	COSMIC	QRSKLSPVL	DEG_APCC_DBOX_1	0.0833
p.D73N	TCGA-MI-A75I	LIHC	TCGA	QRSKLSPVL	DEG_APCC_DBOX_1	0.1667
p.D73N	DO49712	LIHC	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.1667
p.D77G	DO222501	COCA	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.2778
p.V82I	DO234462	ESAD	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.7076
p.V82I	DO233823	GACA	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.7076
p.A84V	DO26502	LUSC	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.6936
p.I90M	DO27011	LUSC	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.25
p.H97Y	DO220877	MELA	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.0556
p.G89E	DO222843	MELA	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.2778
p.T88M	DO47889	STAD	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.3056
p.Q86H	DO42793	UCEC	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.7582
p.V69M	DO42713	UCEC	ICGC	QRSKLSPVL	DEG_APCC_DBOX_1	0.0556
p.V69M	COLO-741	large_intestine	COSMIC	QRSKLSPVL	DEG_APCC_DBOX_1	0.0556
p.S96R	SIDM00233	T-Lymphoblastic Leukemia	GDSC	QRSKLSPVL	DEG_APCC_DBOX_1	0.0833
p.S96R	ACH-002058	Leukemia	CCLE	QRSKLSPVL	DEG_APCC_DBOX_1	0.0833
p.S96R	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	QRSKLSPVL	DEG_APCC_DBOX_1	0.0833
p.D88G	ACH-001610	Brain Cancer	CCLE	QRSKLSPVL	DEG_APCC_DBOX_1	0.3056
p.T73I	COR-L95	lung	COSMIC	QRSKLSPVL	DEG_APCC_DBOX_1	0.1667
p.T77P	NCI-H510A	lung	COSMIC	QRSKLSPVL	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRSKLSPVL

Degron related mutations and impact score

Drug responses associated with TBR1 mutations

All proteins holding degron of QRSKLSPVL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16650	T-box brain protein 1	DEG_APCC_DBOX_1	79:87	QRSKLSPVL	APC,CDC20,FZR1	0.8274	More...