DegronMD

Uniprot ID: Q16650

Source protein: T-box brain protein 1

Source gene: TBR1

Class: DEG_SCF_FBW7_2

Location: 642:649

E3 ligase: FBXW7

DEGRON score: 0.9565

ASA_SCORE: 94.1375

COIL: 0.9423

CONS_SCORE: 0.6993

DSS_SCORE: 0.5962

HELIX: 0.0391

FCONS_SCORE: 0.923

RIG_SCORE: 0.6218

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E649K	TCGA-55-A48Y	LUAD	TCGA	PADTPVSE	DEG_SCF_FBW7_2	0.7022
p.T645M	TCGA-AU-6004	COAD	TCGA	PADTPVSE	DEG_SCF_FBW7_2	0.7423
p.P653Q	TCGA-ER-A19P	SKCM	TCGA	PADTPVSE	DEG_SCF_FBW7_2	0.2222
p.E649G	TCGA-JY-A6FH	ESCA	TCGA	PADTPVSE	DEG_SCF_FBW7_2	0.7199
p.A643V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PADTPVSE	DEG_SCF_FBW7_2	0.5825
p.S651L	SIDM01175	Other Sarcomas	GDSC	PADTPVSE	DEG_SCF_FBW7_2	0.2778
p.S651L	ACH-002309	Sarcoma	CCLE	PADTPVSE	DEG_SCF_FBW7_2	0.2778
p.D644E	SIDM01041	Esophageal Carcinoma	GDSC	PADTPVSE	DEG_SCF_FBW7_2	0.5647
p.D644E	FLO-1	oesophagus	COSMIC	PADTPVSE	DEG_SCF_FBW7_2	0.5647
p.V658M	SIDM00316	Glioblastoma	GDSC	PADTPVSE	DEG_SCF_FBW7_2	0.0833
p.V658M	ACH-000469	Brain Cancer	CCLE	PADTPVSE	DEG_SCF_FBW7_2	0.0833
p.V658M	YH-13	central_nervous_system	COSMIC	PADTPVSE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16650	T-box brain protein 1	DEG_SCF_FBW7_2	642:649	PADTPVSE	FBXW7	0.9565	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons