DegronMD - O15162(PLSCR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G35V	TCGA-49-6761	LUAD	TCGA	PPGY	ITCH	33:36	Mutation altering degron motif	0.6421
p.P27L	TCGA-55-7907	LUAD	TCGA	PPQY	ITCH	22:25	Mutation rewiring degron network	0.2778
p.P27L	TCGA-55-7907	LUAD	TCGA	PPGY	ITCH	33:36	Mutation rewiring degron network	0.1667
p.P27L	SIDM02041	Colorectal Carcinoma	GDSC	PPQY	ITCH	22:25	Mutation rewiring degron network	0.2778
p.P27L	SIDM02041	Colorectal Carcinoma	GDSC	PPGY	ITCH	33:36	Mutation rewiring degron network	0.1667
p.P23A	TCGA-61-1740	OV	TCGA	PPQY	ITCH	22:25	Mutation altering degron motif	0.7503
p.P23R	TCGA-CR-6491	HNSC	TCGA	PPQY	ITCH	22:25	Mutation altering degron motif	0.7512
p.F30L	TCGA-CX-7082	HNSC	TCGA	PPQY	ITCH	22:25	Mutation rewiring degron network	0.1944
p.F30L	TCGA-CX-7082	HNSC	TCGA	PPGY	ITCH	33:36	Mutation rewiring degron network	0.25
p.Q31R	TCGA-D1-A103	UCEC	TCGA	PPQY	ITCH	22:25	Mutation rewiring degron network	0.1667
p.Q31R	TCGA-D1-A103	UCEC	TCGA	PPGY	ITCH	33:36	Mutation rewiring degron network	0.2778
p.H12N	TCGA-G2-A2EK	BLCA	TCGA	PPQY	ITCH	22:25	Mutation rewiring degron network	0.0556
p.H12N	TCGA-XF-A9SY	BLCA	TCGA	PPQY	ITCH	22:25	Mutation rewiring degron network	0.0556
p.G32E	TCGA-YC-A89H	BLCA	TCGA	PPQY	ITCH	22:25	Mutation rewiring degron network	0.1389
p.G32E	TCGA-YC-A89H	BLCA	TCGA	PPGY	ITCH	33:36	Mutation rewiring degron network	0.3056
p.N16H	TCGA-Z6-A8JD	ESCA	TCGA	PPQY	ITCH	22:25	Mutation rewiring degron network	0.1667
p.Y21C	TCGA-ZQ-A9CR	STAD	TCGA	PPQY	ITCH	22:25	Mutation rewiring degron network	0.3056
p.G25E	DO51948	BLCA	ICGC	PPQY	ITCH	22:25	Mutation altering degron motif	0.7199
p.F23L	DO14268	HNSC	ICGC	PPQY	ITCH	22:25	Mutation altering degron motif	0.6981
p.P16R	DO14192	HNSC	ICGC	PPQY	ITCH	22:25	Mutation rewiring degron network	0.1667
p.A44V	DO22237	LGG	ICGC	PPGY	ITCH	33:36	Mutation rewiring degron network	0.1111
p.T21K	DO228986	LICA	ICGC	PPQY	ITCH	22:25	Mutation rewiring degron network	0.3056
p.T21K	DO229025	LICA	ICGC	PPQY	ITCH	22:25	Mutation rewiring degron network	0.3056
p.P15T	DO229031	LICA	ICGC	PPQY	ITCH	22:25	Mutation rewiring degron network	0.1389
p.P19T	DO229034	LICA	ICGC	PPQY	ITCH	22:25	Mutation rewiring degron network	0.25
p.P20T	DO229036	LICA	ICGC	PPQY	ITCH	22:25	Mutation rewiring degron network	0.2778
p.P35S	DO50964	LICA	ICGC	PPGY	ITCH	33:36	Mutation altering degron motif	0.6752
p.G28V	DO24566	LUAD	ICGC	PPQY	ITCH	22:25	Mutation rewiring degron network	0.25
p.G28V	DO24566	LUAD	ICGC	PPGY	ITCH	33:36	Mutation rewiring degron network	0.1944
p.P16A	DO27981	OV	ICGC	PPQY	ITCH	22:25	Mutation rewiring degron network	0.1667
p.Y14C	DO50145	STAD	ICGC	PPQY	ITCH	22:25	Mutation rewiring degron network	0.1111
p.Q24R	DO42312	UCEC	ICGC	PPQY	ITCH	22:25	Mutation altering degron motif	0.6218
p.G20V	SIDM00672	Hepatocellular Carcinoma	GDSC	PPQY	ITCH	22:25	Mutation rewiring degron network	0.2778
p.G20V	SIDM01090	Colorectal Carcinoma	GDSC	PPQY	ITCH	22:25	Mutation rewiring degron network	0.2778
p.G20V	SIDM00954	Breast Carcinoma	GDSC	PPQY	ITCH	22:25	Mutation rewiring degron network	0.2778
p.Y21H	SIDM01608	Endometrial Carcinoma	GDSC	PPQY	ITCH	22:25	Mutation rewiring degron network	0.3056
p.Y21H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPQY	ITCH	22:25	Mutation rewiring degron network	0.3056
p.A29S	ACH-000999	Colon/Colorectal Cancer	CCLE	PPQY	ITCH	22:25	Mutation rewiring degron network	0.2222
p.A29S	ACH-000999	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	33:36	Mutation rewiring degron network	0.2222
p.A29S	SNU-1040	large intestine	COSMIC	PPQY	ITCH	22:25	Mutation rewiring degron network	0.2222
p.A29S	SNU-1040	large intestine	COSMIC	PPGY	ITCH	33:36	Mutation rewiring degron network	0.2222
p.A22S	SNU-1040	large intestine	COSMIC	PPQY	ITCH	22:25	Mutation altering degron motif	0.7588
p.D25N	LNCaP-Clone-FGC	prostate	COSMIC	PPQY	ITCH	22:25	Mutation altering degron motif	0.6932
p.T44N	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	33:36	Mutation rewiring degron network	0.1111
p.Q20H	SNU-1040	large intestine	COSMIC	PPQY	ITCH	22:25	Mutation rewiring degron network	0.2778

Kaplan plot for PLSCR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLSCR1

UniProt ID: O15162

Entrez ID: 5359

Protein name: Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Erythrocyte phospholipid scramblase) (Mg(2+)-dependent nuclease) (EC 3.1.-.-) (MmTRA1b)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLSCR1 in