DegronMD - P10153(RNASE2)

FUNCTION: This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities. {ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:3458170}.

GO - Biological processes (BP): chemotaxis [GO:0006935]; defense response to virus [GO:0051607]; innate immune response in mucosa [GO:0002227]; RNA catabolic process [GO:0006401]; RNA phosphodiester bond hydrolysis [GO:0090501]

GO - Molecular function (MF): lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; ribonuclease activity [GO:0004540]

GO - Cellular component (CC): azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
PPQY	ITCH	ITCH,NEDD4	Non-secretory ribonuclease	147:150	More..
VPVHLD	LIG_APCC_ABBA_1	APC,CDC20,FZR1	Non-secretory ribonuclease	153:158	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P147H	TCGA-12-0820	GBM	TCGA	PPQY	ITCH	147:150	Mutation altering degron motif	0.7694
p.P147H	DO12838	GBM	ICGC	PPQY	ITCH	147:150	Mutation altering degron motif	0.7694
p.L157M	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.5999
p.L157M	ACH-000878	Lung Cancer	CCLE	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.5999
p.L157M	HCC-15	lung	COSMIC	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.5999
p.P151L	TCGA-A5-A0G2	UCEC	TCGA	PPQY	ITCH	147:150	Mutation rewiring degron network	0.3056
p.P151L	DO41235	UCEC	ICGC	PPQY	ITCH	147:150	Mutation rewiring degron network	0.3056
p.R159I	TCGA-AP-A1DV	UCEC	TCGA	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.3056
p.R159I	DO43186	UCEC	ICGC	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.3056
p.P151T	TCGA-WK-A8Y0	SARC	TCGA	PPQY	ITCH	147:150	Mutation rewiring degron network	0.3056
p.P151T	DO220305	SARC	ICGC	PPQY	ITCH	147:150	Mutation rewiring degron network	0.3056
p.I160M	TCGA-22-4595	LUSC	TCGA	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2778
p.I160M	DO26641	LUSC	ICGC	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2778
p.P151L	TCGA-A5-A0G2	UCEC	TCGA	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2778
p.P151L	DO41235	UCEC	ICGC	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2778
p.R145Q	TCGA-DX-A7ET	SARC	TCGA	PPQY	ITCH	147:150	Mutation rewiring degron network	0.2778
p.R145Q	TCGA-Z2-A8RT	SKCM	TCGA	PPQY	ITCH	147:150	Mutation rewiring degron network	0.2778
p.R145Q	DO220038	SARC	ICGC	PPQY	ITCH	147:150	Mutation rewiring degron network	0.2778
p.R145Q	DO51301	SKCM	ICGC	PPQY	ITCH	147:150	Mutation rewiring degron network	0.2778
p.P151T	TCGA-WK-A8Y0	SARC	TCGA	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 42 entries

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No resistance data available for this Degron.

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNASE2

UniProt ID: P10153

Entrez ID: 6036

Protein name: Non-secretory ribonuclease (EC 4.6.1.18) (Eosinophil-derived neurotoxin) (RNase UpI-2) (Ribonuclease 2) (RNase 2) (Ribonuclease US)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for RNASE2 in