DegronMD - P10153(RNASE2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P147H	TCGA-12-0820	GBM	TCGA	PPQY	ITCH	147:150	Mutation altering degron motif	0.7694
p.P147H	DO12838	GBM	ICGC	PPQY	ITCH	147:150	Mutation altering degron motif	0.7694
p.I160M	TCGA-22-4595	LUSC	TCGA	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2778
p.I160M	TCGA-22-4595	LUSC	TCGA	PPQY	ITCH	147:150	Mutation rewiring degron network	0.0556
p.I160M	DO26641	LUSC	ICGC	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2778
p.I160M	DO26641	LUSC	ICGC	PPQY	ITCH	147:150	Mutation rewiring degron network	0.0556
p.P151L	TCGA-A5-A0G2	UCEC	TCGA	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2778
p.P151L	TCGA-A5-A0G2	UCEC	TCGA	PPQY	ITCH	147:150	Mutation rewiring degron network	0.3056
p.P151L	DO41235	UCEC	ICGC	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2778
p.P151L	DO41235	UCEC	ICGC	PPQY	ITCH	147:150	Mutation rewiring degron network	0.3056
p.R159I	TCGA-AP-A1DV	UCEC	TCGA	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.3056
p.R159I	TCGA-AP-A1DV	UCEC	TCGA	PPQY	ITCH	147:150	Mutation rewiring degron network	0.0833
p.R159I	DO43186	UCEC	ICGC	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.3056
p.R159I	DO43186	UCEC	ICGC	PPQY	ITCH	147:150	Mutation rewiring degron network	0.0833
p.R145Q	TCGA-DX-A7ET	SARC	TCGA	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1111
p.R145Q	TCGA-DX-A7ET	SARC	TCGA	PPQY	ITCH	147:150	Mutation rewiring degron network	0.2778
p.R145Q	TCGA-Z2-A8RT	SKCM	TCGA	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1111
p.R145Q	TCGA-Z2-A8RT	SKCM	TCGA	PPQY	ITCH	147:150	Mutation rewiring degron network	0.2778
p.R145Q	DO220038	SARC	ICGC	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1111
p.R145Q	DO220038	SARC	ICGC	PPQY	ITCH	147:150	Mutation rewiring degron network	0.2778
p.R145Q	DO51301	SKCM	ICGC	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1111
p.R145Q	DO51301	SKCM	ICGC	PPQY	ITCH	147:150	Mutation rewiring degron network	0.2778
p.R141I	TCGA-E6-A1LX	UCEC	TCGA	PPQY	ITCH	147:150	Mutation rewiring degron network	0.1667
p.R141I	DO41020	UCEC	ICGC	PPQY	ITCH	147:150	Mutation rewiring degron network	0.1667
p.D142Y	TCGA-E6-A1LX	UCEC	TCGA	PPQY	ITCH	147:150	Mutation rewiring degron network	0.1944
p.D142Y	DO41020	UCEC	ICGC	PPQY	ITCH	147:150	Mutation rewiring degron network	0.1944
p.P151T	TCGA-WK-A8Y0	SARC	TCGA	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2778
p.P151T	TCGA-WK-A8Y0	SARC	TCGA	PPQY	ITCH	147:150	Mutation rewiring degron network	0.3056
p.P151T	DO220305	SARC	ICGC	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2778
p.P151T	DO220305	SARC	ICGC	PPQY	ITCH	147:150	Mutation rewiring degron network	0.3056
p.R145L	DO229015	LICA	ICGC	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1111
p.R145L	DO229015	LICA	ICGC	PPQY	ITCH	147:150	Mutation rewiring degron network	0.2778
p.Q143H	DO222494	MELA	ICGC	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.0556
p.Q143H	DO222494	MELA	ICGC	PPQY	ITCH	147:150	Mutation rewiring degron network	0.2222
p.R144P	SIDM01199	Hepatocellular Carcinoma	GDSC	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.0833
p.R144P	SIDM01199	Hepatocellular Carcinoma	GDSC	PPQY	ITCH	147:150	Mutation rewiring degron network	0.25
p.R144P	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.0833
p.R144P	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PPQY	ITCH	147:150	Mutation rewiring degron network	0.25
p.L157M	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.5999
p.L157M	ACH-000878	Lung Cancer	CCLE	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.5999
p.L157M	HCC-15	lung	COSMIC	VPVHLD	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.5999
p.D139V	ACH-000773	Lymphoma	CCLE	PPQY	ITCH	147:150	Mutation rewiring degron network	0.1111

Kaplan plot for RNASE2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNASE2

UniProt ID: P10153

Entrez ID: 6036

Protein name: Non-secretory ribonuclease (EC 4.6.1.18) (Eosinophil-derived neurotoxin) (RNase UpI-2) (Ribonuclease 2) (RNase 2) (Ribonuclease US)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RNASE2 in