DegronMD

Uniprot ID: P10153

Source protein: Non-secretory ribonuclease

Source gene: RNASE2

Class: LIG_APCC_ABBA_1

Location: 153:158

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9586

ASA_SCORE: 40.4333

COIL: 0.7435

CONS_SCORE: 0.9598

DSS_SCORE: 0.5501

HELIX: 0.0377

FCONS_SCORE: 1.4064

RIG_SCORE: 0.8453

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I160M	TCGA-22-4595	LUSC	TCGA	VPVHLD	LIG_APCC_ABBA_1	0.2778
p.I160M	DO26641	LUSC	ICGC	VPVHLD	LIG_APCC_ABBA_1	0.2778
p.P151L	TCGA-A5-A0G2	UCEC	TCGA	VPVHLD	LIG_APCC_ABBA_1	0.2778
p.P151L	DO41235	UCEC	ICGC	VPVHLD	LIG_APCC_ABBA_1	0.2778
p.R159I	TCGA-AP-A1DV	UCEC	TCGA	VPVHLD	LIG_APCC_ABBA_1	0.3056
p.R159I	DO43186	UCEC	ICGC	VPVHLD	LIG_APCC_ABBA_1	0.3056
p.R145Q	TCGA-DX-A7ET	SARC	TCGA	VPVHLD	LIG_APCC_ABBA_1	0.1111
p.R145Q	TCGA-Z2-A8RT	SKCM	TCGA	VPVHLD	LIG_APCC_ABBA_1	0.1111
p.R145Q	DO220038	SARC	ICGC	VPVHLD	LIG_APCC_ABBA_1	0.1111
p.R145Q	DO51301	SKCM	ICGC	VPVHLD	LIG_APCC_ABBA_1	0.1111
p.P151T	TCGA-WK-A8Y0	SARC	TCGA	VPVHLD	LIG_APCC_ABBA_1	0.2778
p.P151T	DO220305	SARC	ICGC	VPVHLD	LIG_APCC_ABBA_1	0.2778
p.R145L	DO229015	LICA	ICGC	VPVHLD	LIG_APCC_ABBA_1	0.1111
p.Q143H	DO222494	MELA	ICGC	VPVHLD	LIG_APCC_ABBA_1	0.0556
p.R144P	SIDM01199	Hepatocellular Carcinoma	GDSC	VPVHLD	LIG_APCC_ABBA_1	0.0833
p.R144P	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	VPVHLD	LIG_APCC_ABBA_1	0.0833
p.L157M	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VPVHLD	LIG_APCC_ABBA_1	0.5999
p.L157M	ACH-000878	Lung Cancer	CCLE	VPVHLD	LIG_APCC_ABBA_1	0.5999
p.L157M	HCC-15	lung	COSMIC	VPVHLD	LIG_APCC_ABBA_1	0.5999

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10153	Non-secretory ribonuclease	LIG_APCC_ABBA_1	153:158	VPVHLD	APC,CDC20,FZR1	0.9586	More...
P12724	Eosinophil cationic protein	LIG_APCC_ABBA_1	152:157	VPVHLD	APC,CDC20,FZR1	0.9805	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons