DegronMD

Uniprot ID: P12724

Source protein: Eosinophil cationic protein

Source gene: RNASE3

Class: LIG_APCC_ABBA_1

Location: 152:157

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9805

ASA_SCORE: 38.4167

COIL: 0.7092

CONS_SCORE: 0.9475

DSS_SCORE: 0.6159

HELIX: 0.0485

FCONS_SCORE: 1.2367

RIG_SCORE: 0.8055

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P150S	DO222595	MELA	ICGC	VPVHLD	LIG_APCC_ABBA_1	0.2778
p.I160T	TCGA-96-7544	LUSC	TCGA	VPVHLD	LIG_APCC_ABBA_1	0.25
p.I160T	DO26425	LUSC	ICGC	VPVHLD	LIG_APCC_ABBA_1	0.25
p.I160T	SIDM00299	Other Sarcomas	GDSC	VPVHLD	LIG_APCC_ABBA_1	0.25
p.I160T	ACH-002271	Sarcoma	CCLE	VPVHLD	LIG_APCC_ABBA_1	0.25
p.I160T	MFH-ino	soft_tissue	COSMIC	VPVHLD	LIG_APCC_ABBA_1	0.25
p.S146Y	DO222884	COCA	ICGC	VPVHLD	LIG_APCC_ABBA_1	0.1667
p.R144L	TCGA-69-7979	LUAD	TCGA	VPVHLD	LIG_APCC_ABBA_1	0.1111
p.R144L	DO23874	LUAD	ICGC	VPVHLD	LIG_APCC_ABBA_1	0.1111
p.P143S	DO222494	MELA	ICGC	VPVHLD	LIG_APCC_ABBA_1	0.0833

Showing 1 to 10 of 10 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12724	Eosinophil cationic protein	LIG_APCC_ABBA_1	152:157	VPVHLD	APC,CDC20,FZR1	0.9805	More...
P10153	Non-secretory ribonuclease	LIG_APCC_ABBA_1	153:158	VPVHLD	APC,CDC20,FZR1	0.9586	More...

Showing 1 to 2 of 2 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons