DegronMD - P12724(RNASE3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R144L	TCGA-69-7979	LUAD	TCGA	VPVHLD	LIG_APCC_ABBA_1	152:157	Mutation rewiring degron network	0.1111
p.R144L	DO23874	LUAD	ICGC	VPVHLD	LIG_APCC_ABBA_1	152:157	Mutation rewiring degron network	0.1111
p.I160T	TCGA-96-7544	LUSC	TCGA	VPVHLD	LIG_APCC_ABBA_1	152:157	Mutation rewiring degron network	0.25
p.I160T	DO26425	LUSC	ICGC	VPVHLD	LIG_APCC_ABBA_1	152:157	Mutation rewiring degron network	0.25
p.I160T	SIDM00299	Other Sarcomas	GDSC	VPVHLD	LIG_APCC_ABBA_1	152:157	Mutation rewiring degron network	0.25
p.I160T	ACH-002271	Sarcoma	CCLE	VPVHLD	LIG_APCC_ABBA_1	152:157	Mutation rewiring degron network	0.25
p.I160T	MFH-ino	soft tissue	COSMIC	VPVHLD	LIG_APCC_ABBA_1	152:157	Mutation rewiring degron network	0.25
p.S146Y	DO222884	COCA	ICGC	VPVHLD	LIG_APCC_ABBA_1	152:157	Mutation rewiring degron network	0.1667
p.P143S	DO222494	MELA	ICGC	VPVHLD	LIG_APCC_ABBA_1	152:157	Mutation rewiring degron network	0.0833
p.P150S	DO222595	MELA	ICGC	VPVHLD	LIG_APCC_ABBA_1	152:157	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons