DegronMD

Uniprot ID: P35680

Source protein: Hepatocyte nuclear factor 1-beta

Source gene: HNF1B

Class: ITCH

Location: 519:522

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9746

ASA_SCORE: 92.525

COIL: 0.9313

CONS_SCORE: 0.735

DSS_SCORE: 0.597

HELIX: 0.0208

FCONS_SCORE: 1.1872

RIG_SCORE: 0.622

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F528S	TCGA-14-0862	GBM	TCGA	PPQY	ITCH	0.1667
p.F528S	DO12430	GBM	ICGC	PPQY	ITCH	0.1667
p.P519L	TCGA-61-1914	OV	TCGA	PPQY	ITCH	0.7582
p.P519L	DO28105	OV	ICGC	PPQY	ITCH	0.7582
p.R527W	TCGA-AX-A2HD	UCEC	TCGA	PPQY	ITCH	0.1944
p.R527W	DO42608	UCEC	ICGC	PPQY	ITCH	0.1944
p.Y522H	TCGA-BG-A221	UCEC	TCGA	PPQY	ITCH	0.7229
p.Y522H	DO42384	UCEC	ICGC	PPQY	ITCH	0.7229
p.R526C	DO222798	COCA	ICGC	PPQY	ITCH	0.2222
p.R526C	DO220862	MELA	ICGC	PPQY	ITCH	0.2222
p.R526C	DO36556	READ	ICGC	PPQY	ITCH	0.2222
p.R526C	DO37442	SKCM	ICGC	PPQY	ITCH	0.2222
p.R526C	DO38123	SKCM	ICGC	PPQY	ITCH	0.2222
p.R526C	DO38663	STAD	ICGC	PPQY	ITCH	0.2222
p.R526C	DO223286	UCEC	ICGC	PPQY	ITCH	0.2222
p.R526C	DO43891	UCEC	ICGC	PPQY	ITCH	0.2222
p.R526C	DO42793	UCEC	ICGC	PPQY	ITCH	0.2222
p.L525F	DO234409	ESAD	ICGC	PPQY	ITCH	0.25
p.R526H	DO21637	LAML	ICGC	PPQY	ITCH	0.2222
p.R526H	DO27739	LUSC	ICGC	PPQY	ITCH	0.2222
p.R526H	ACH-001377	Pancreatic Cancer	CCLE	PPQY	ITCH	0.2222
p.H523Y	DO36860	READ	ICGC	PPQY	ITCH	0.3056
p.G531E	DO48665	SKCM	ICGC	PPQY	ITCH	0.0833
p.A527V	DO43755	UCEC	ICGC	PPQY	ITCH	0.1944
p.M532V	SIDM01137	Pancreatic Carcinoma	GDSC	PPQY	ITCH	0.0556
p.A514T	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PPQY	ITCH	0.1944
p.A514T	ACH-000938	Leukemia	CCLE	PPQY	ITCH	0.1944

Drug responses associated with HNF1B mutations

All proteins holding degron of PPQY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15162	Phospholipid scramblase 1	ITCH	22:25	PPQY	ITCH,NEDD4	0.9984	More...
O43809	Cleavage and polyadenylation specificity factor subunit 5	ITCH	155:158	PPQY	ITCH,NEDD4	0.5897	More...
O75791	GRB2-related adapter protein 2	ITCH	204:207	PPQY	ITCH,NEDD4	0.675	More...
P10153	Non-secretory ribonuclease	ITCH	147:150	PPQY	ITCH,NEDD4	0.8403	More...
P35680	Hepatocyte nuclear factor 1-beta	ITCH	519:522	PPQY	ITCH,NEDD4	0.9746	More...
P47902	Homeobox protein CDX-1	ITCH	39:42	PPQY	ITCH,NEDD4	0.9834	More...
Q15751	Probable E3 ubiquitin-protein ligase HERC1	ITCH	4383:4386	PPQY	ITCH,NEDD4	0.6066	More...
Q16650	T-box brain protein 1	ITCH	550:553	PPQY	ITCH,NEDD4	0.9804	More...
Q24JP5	Transmembrane protein 132A	ITCH	244:247	PPQY	ITCH,NEDD4	0.8056	More...
Q5JTH9	RRP12-like protein	ITCH	1209:1212	PPQY	ITCH,NEDD4	0.8336	More...
Q68CP9	AT-rich interactive domain-containing protein 2	ITCH	850:853	PPQY	ITCH,NEDD4	0.9824	More...
Q71SY5	Mediator of RNA polymerase II transcription subunit 25	ITCH	269:272	PPQY	ITCH,NEDD4	0.9206	More...
Q8IVH2	Forkhead box protein P4	ITCH	628:631	PPQY	ITCH,NEDD4	0.899	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	ITCH	581:584	PPQY	ITCH,NEDD4	0.8798	More...
Q8TB72	Pumilio homolog 2	ITCH	342:345	PPQY	ITCH,NEDD4	0.751	More...
Q92585	Mastermind-like protein 1	ITCH	670:673	PPQY	ITCH,NEDD4	0.9964	More...
Q96RT1	Erbin	ITCH	974:977	PPQY	ITCH,NEDD4	0.9986	More...
Q99626	Homeobox protein CDX-2	ITCH	34:37	PPQY	ITCH,NEDD4	0.7582	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	ITCH	951:954	PPQY	ITCH,NEDD4	0.9234	More...
Q9H7P6	Multivesicular body subunit 12B	ITCH	173:176	PPQY	ITCH,NEDD4	0.9906	More...
Q9NW97	Transmembrane protein 51	ITCH	236:239	PPQY	ITCH,NEDD4	0.9991	More...
Q9NZ53	Podocalyxin-like protein 2	ITCH	94:97	PPQY	ITCH,NEDD4	0.6559	More...
Q9P0N8	E3 ubiquitin-protein ligase MARCHF2	ITCH	33:36	PPQY	ITCH,NEDD4	0.7278	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	ITCH	587:590	PPQY	ITCH,NEDD4	0.9964	More...
Q9UPX0	Protein turtle homolog B	ITCH	145:148	PPQY	ITCH,NEDD4	0.7346	More...
Q9Y2J4	Angiomotin-like protein 2	ITCH	210:213	PPQY	ITCH,NEDD4	0.9661	More...
Q5T0L3	Spermatogenesis-associated protein 46	ITCH	53:56	PPQY	ITCH,NEDD4	0.9935	More...
Q86VI1	Exocyst complex component 3-like protein	ITCH	299:302	PPQY	ITCH,NEDD4	0.6459	More...
Q8WUU8	Transmembrane protein 174	ITCH	179:182	PPQY	ITCH,NEDD4	0.9754	More...
Q9ULL0	Acrosomal protein KIAA1210	ITCH	1154:1157	PPQY	ITCH,NEDD4	0.9027	More...
P0CJ78	Zinc finger protein 865	ITCH	74:77	PPQY	ITCH,NEDD4	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPQY

Degron related mutations and impact score

Drug responses associated with HNF1B mutations

All proteins holding degron of PPQY