DegronMD - Q9UHV7(MED13)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S859N	TCGA-06-5416	GBM	TCGA	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation rewiring degron network	0.3056
p.S859N	DO10880	GBM	ICGC	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation rewiring degron network	0.3056
p.S874C	TCGA-44-7670	LUAD	TCGA	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation rewiring degron network	0.1389
p.S874C	TCGA-AC-A23H	BRCA	TCGA	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation rewiring degron network	0.1389
p.S874C	DO2401	BRCA	ICGC	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation rewiring degron network	0.1389
p.S874C	DO23555	LUAD	ICGC	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation rewiring degron network	0.1389
p.S1539L	TCGA-4Z-AA80	BLCA	TCGA	ASTSS	DEG_SPOP_SBC_1	1536:1540	Mutation altering degron motif	0.7667
p.S1539L	DO218986	BLCA	ICGC	ASTSS	DEG_SPOP_SBC_1	1536:1540	Mutation altering degron motif	0.7667
p.T1501A	TCGA-A5-A1OF	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.1111
p.T1501A	DO42568	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.1111
p.A777V	TCGA-AP-A0LM	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1111
p.A777V	DO43306	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1111
p.L776M	TCGA-AX-A1CE	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1389
p.L776M	DO42280	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1389
p.S177N	TCGA-BK-A6W3	UCEC	TCGA	FFLHGD	LIG_APCC_ABBA_1	166:171	Mutation rewiring degron network	0.1667
p.S177N	DO50076	UCEC	ICGC	FFLHGD	LIG_APCC_ABBA_1	166:171	Mutation rewiring degron network	0.1667
p.A1068S	TCGA-BS-A0UF	UCEC	TCGA	SVEPATVPSI	DEG_COP1_1	1056:1065	Mutation rewiring degron network	0.25
p.A1068S	DO41488	UCEC	ICGC	SVEPATVPSI	DEG_COP1_1	1056:1065	Mutation rewiring degron network	0.25
p.M850I	TCGA-BS-A0UV	UCEC	TCGA	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation rewiring degron network	0.0556
p.M850I	DO42793	UCEC	ICGC	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation rewiring degron network	0.0556
p.Q335H	TCGA-CA-6717	COAD	TCGA	VTLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation rewiring degron network	0.1944
p.Q335H	DO8264	COAD	ICGC	VTLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation rewiring degron network	0.1944
p.P1059H	TCGA-CD-A4MG	STAD	TCGA	SVEPATVPSI	DEG_COP1_1	1056:1065	Mutation altering degron motif	0.6583
p.P1059H	DO48009	STAD	ICGC	SVEPATVPSI	DEG_COP1_1	1056:1065	Mutation altering degron motif	0.6583
p.M1944L	TCGA-CV-7435	HNSC	TCGA	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.1944
p.M1944L	DO14918	HNSC	ICGC	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.1944
p.D755Y	TCGA-D3-A2JC	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.0556
p.D755Y	DO47578	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.0556
p.P759H	TCGA-DA-A1IB	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1667
p.P759H	DO38033	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1667
p.R758C	TCGA-DD-A4NO	LIHC	TCGA	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1389
p.R758C	DO45013	LIHC	ICGC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1389
p.N181S	TCGA-DD-AAE7	LIHC	TCGA	FFLHGD	LIG_APCC_ABBA_1	166:171	Mutation rewiring degron network	0.0556
p.N181S	DO52262	LIHC	ICGC	FFLHGD	LIG_APCC_ABBA_1	166:171	Mutation rewiring degron network	0.0556
p.N181S	DO27895	ORCA	ICGC	FFLHGD	LIG_APCC_ABBA_1	166:171	Mutation rewiring degron network	0.0556
p.M1944I	TCGA-DF-A2KN	UCEC	TCGA	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.1944
p.M1944I	DO223282	UCEC	ICGC	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.1944
p.P1502A	TCGA-DX-A240	SARC	TCGA	AASST	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.1389
p.P1502A	DO219960	SARC	ICGC	AASST	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.1389
p.D775Y	TCGA-EO-A22R	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1667
p.D775Y	DO42713	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1667
p.S583P	TCGA-EO-A22R	UCEC	TCGA	PPQY	ITCH	587:590	Mutation rewiring degron network	0.2222
p.S583P	DO42713	UCEC	ICGC	PPQY	ITCH	587:590	Mutation rewiring degron network	0.2222
p.A1499V	TCGA-EO-A22U	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.0556
p.A1499V	DO43755	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.0556
p.E856Q	TCGA-FD-A6TA	BLCA	TCGA	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation rewiring degron network	0.2222
p.E856Q	DO49753	BLCA	ICGC	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation rewiring degron network	0.2222
p.A1510V	TCGA-NH-A6GB	COAD	TCGA	AASST	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.5825
p.A1510V	DO50092	COAD	ICGC	AASST	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.5825
p.A1510V	DO230968	LUSC	ICGC	AASST	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.5825
p.A1510V	DO224621	LUSC	ICGC	AASST	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.5825
p.E179K	TCGA-UY-A9PF	BLCA	TCGA	FFLHGD	LIG_APCC_ABBA_1	166:171	Mutation rewiring degron network	0.1111
p.E179K	DO219044	BLCA	ICGC	FFLHGD	LIG_APCC_ABBA_1	166:171	Mutation rewiring degron network	0.1111
p.S1939G	TCGA-UZ-A9PS	KIRP	TCGA	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.0556
p.S1939G	DO219709	KIRP	ICGC	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.0556
p.N1545K	TCGA-YG-AA3N	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	1536:1540	Mutation rewiring degron network	0.1944
p.N1545K	DO51298	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	1536:1540	Mutation rewiring degron network	0.1944
p.L582F	DO224722	BRCA	ICGC	PPQY	ITCH	587:590	Mutation rewiring degron network	0.1944
p.Y772N	DO1187	BRCA	ICGC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.25
p.C1051R	DO234417	ESAD	ICGC	SVEPATVPSI	DEG_COP1_1	1056:1065	Mutation rewiring degron network	0.1944
p.N1074K	DO233629	GACA	ICGC	SVEPATVPSI	DEG_COP1_1	1056:1065	Mutation rewiring degron network	0.0833
p.Q340H	DO49665	LIAD	ICGC	VTLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation rewiring degron network	0.0556
p.T1524N	DO228976	LICA	ICGC	AISTS	DEG_SPOP_SBC_1	1521:1525	Mutation altering degron motif	0.7055
p.P318T	DO229024	LICA	ICGC	VTLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation rewiring degron network	0.1944
p.P765H	DO229026	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation altering degron motif	0.7694
p.P765H	DO229045	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation altering degron motif	0.7694
p.A1068E	DO229032	LICA	ICGC	SVEPATVPSI	DEG_COP1_1	1056:1065	Mutation rewiring degron network	0.25
p.N181K	DO229035	LICA	ICGC	FFLHGD	LIG_APCC_ABBA_1	166:171	Mutation rewiring degron network	0.0556
p.A1499S	DO23270	LINC	ICGC	AASST	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.0556
p.Y772C	DO48730	LIRI	ICGC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.25
p.P759T	DO35442	PACA	ICGC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1667
p.V868F	DO229213	THCA	ICGC	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation rewiring degron network	0.3056
p.C162Y	DO229248	THCA	ICGC	FFLHGD	LIG_APCC_ABBA_1	166:171	Mutation rewiring degron network	0.2222
p.H1069Q	SIDM00570	Gastric Carcinoma	GDSC	SVEPATVPSI	DEG_COP1_1	1056:1065	Mutation rewiring degron network	0.2222
p.H1069Q	ACH-000674	Gastric Cancer	CCLE	SVEPATVPSI	DEG_COP1_1	1056:1065	Mutation rewiring degron network	0.2222
p.A1521P	SIDM00845	Burkitt's Lymphoma	GDSC	AISTS	DEG_SPOP_SBC_1	1521:1525	Mutation altering degron motif	0.6392
p.A1521P	SIDM01519	Head and Neck Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	1521:1525	Mutation altering degron motif	0.6392
p.V1516M	SIDM00845	Burkitt's Lymphoma	GDSC	AASST	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.25
p.V1516M	SIDM00845	Burkitt's Lymphoma	GDSC	AISTS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.1944
p.Y590F	SIDM00845	Burkitt's Lymphoma	GDSC	PPQY	ITCH	587:590	Mutation altering degron motif	0.7528
p.Y590F	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPQY	ITCH	587:590	Mutation altering degron motif	0.7528
p.Q589P	SIDM00845	Burkitt's Lymphoma	GDSC	PPQY	ITCH	587:590	Mutation altering degron motif	0.5924
p.Q589P	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPQY	ITCH	587:590	Mutation altering degron motif	0.5924
p.T1940M	SIDM01090	Colorectal Carcinoma	GDSC	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.0833
p.T1940M	ACH-000943	Colon/Colorectal Cancer	CCLE	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.0833
p.T1940M	RKO	large intestine	COSMIC	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.0833
p.Q584R	SIDM00277	Acute Myeloid Leukemia	GDSC	PPQY	ITCH	587:590	Mutation rewiring degron network	0.25
p.C1957G	SIDM00754	Non-Small Cell Lung Carcinoma	GDSC	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.2778
p.C1957G	ACH-000379	Lung Cancer	CCLE	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.2778
p.C1957G	NCI-H1781	lung	COSMIC	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.2778
p.T760S	SIDM00335	Endometrial Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1944
p.T760S	ACH-000192	Endometrial/Uterine Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1944
p.T760S	MFE-280	endometrium	COSMIC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1944
p.P1063S	SIDM00853	Other Sarcomas	GDSC	SVEPATVPSI	DEG_COP1_1	1056:1065	Mutation altering degron motif	0.6752
p.P1063S	ACH-000835	Sarcoma	CCLE	SVEPATVPSI	DEG_COP1_1	1056:1065	Mutation altering degron motif	0.6752
p.P1063S	GCT	soft tissue	COSMIC	SVEPATVPSI	DEG_COP1_1	1056:1065	Mutation altering degron motif	0.6752
p.S779C	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.0556
p.S779C	H513	pleura	COSMIC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.0556
p.N1943Y	SIDM01019	Acute Myeloid Leukemia	GDSC	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.1667
p.N1943Y	ACH-002258	Leukemia	CCLE	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.1667
p.N1943Y	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.1667
p.D773N	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.2222
p.D773N	ACH-000875	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.2222
p.D773N	NCI-H2347	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.2222
p.F1963S	SIDM00118	Colorectal Carcinoma	GDSC	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.1111
p.F1963S	ACH-001081	Colon/Colorectal Cancer	CCLE	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.1111
p.F1963S	HCC2998	large intestine	COSMIC	LNTPQDT	DEG_SCF_FBW7_1	1949:1955	Mutation rewiring degron network	0.1111
p.I876M	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation rewiring degron network	0.0833
p.I876M	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation rewiring degron network	0.0833
p.S761N	SIDM01519	Head and Neck Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.2222
p.T862A	SIDM01574	Plasma Cell Myeloma	GDSC	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation altering degron motif	0.6028
p.T862A	ACH-000588	Myeloma	CCLE	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation altering degron motif	0.6028
p.F166L	SIDM01343	Gastric Carcinoma	GDSC	FFLHGD	LIG_APCC_ABBA_1	166:171	Mutation altering degron motif	0.587
p.F166L	ACH-000764	Gastric Cancer	CCLE	FFLHGD	LIG_APCC_ABBA_1	166:171	Mutation altering degron motif	0.587
p.T862K	ACH-000219	Skin Cancer	CCLE	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation altering degron motif	0.6195
p.T862K	ACH-000470	Colon/Colorectal Cancer	CCLE	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation altering degron motif	0.6195
p.T862K	ACH-001199	Colon/Colorectal Cancer	CCLE	MDTTPGGT	DEG_SCF_FBW7_1	860:867	Mutation altering degron motif	0.6195
p.M1514I	ACH-000901	Lung Cancer	CCLE	AASST	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.3056
p.M1514I	ACH-000901	Lung Cancer	CCLE	AISTS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.1389
p.V594I	ACH-001484	Leukemia	CCLE	PPQY	ITCH	587:590	Mutation rewiring degron network	0.2222
p.V594I	ACH-001485	Leukemia	CCLE	PPQY	ITCH	587:590	Mutation rewiring degron network	0.2222
p.R764H	ACH-001610	Brain Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MED13

UniProt ID: Q9UHV7

Entrez ID: 9969

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MED13 in