DegronMD

Uniprot ID: Q9UHV7

Source protein: Mediator of RNA polymerase II transcription subunit 13

Source gene: MED13

Class: DEG_SCF_FBW7_1

Location: 323:330

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 77.5125

COIL: 0.9616

CONS_SCORE: 0.3249

DSS_SCORE: 0.6428

HELIX: 0.0126

FCONS_SCORE: 0.996

RIG_SCORE: 0.6644

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q335H	TCGA-CA-6717	COAD	TCGA	VTLTPPTS	DEG_SCF_FBW7_1	0.1944
p.Q335H	DO8264	COAD	ICGC	VTLTPPTS	DEG_SCF_FBW7_1	0.1944
p.Q340H	DO49665	LIAD	ICGC	VTLTPPTS	DEG_SCF_FBW7_1	0.0556
p.P318T	DO229024	LICA	ICGC	VTLTPPTS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SCF_FBW7_1	323:330	VTLTPPTS	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons