DegronMD

Uniprot ID: Q9UHV7

Source protein: Mediator of RNA polymerase II transcription subunit 13

Source gene: MED13

Class: LIG_APCC_ABBA_1

Location: 166:171

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.571

ASA_SCORE: 39.15

COIL: 0.4328

CONS_SCORE: 0.5749

DSS_SCORE: 0.0659

HELIX: 0.0097

FCONS_SCORE: 1.2646

RIG_SCORE: 0.7924

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S177N	TCGA-BK-A6W3	UCEC	TCGA	FFLHGD	LIG_APCC_ABBA_1	0.1667
p.S177N	DO50076	UCEC	ICGC	FFLHGD	LIG_APCC_ABBA_1	0.1667
p.N181S	TCGA-DD-AAE7	LIHC	TCGA	FFLHGD	LIG_APCC_ABBA_1	0.0556
p.N181S	DO52262	LIHC	ICGC	FFLHGD	LIG_APCC_ABBA_1	0.0556
p.N181S	DO27895	ORCA	ICGC	FFLHGD	LIG_APCC_ABBA_1	0.0556
p.E179K	TCGA-UY-A9PF	BLCA	TCGA	FFLHGD	LIG_APCC_ABBA_1	0.1111
p.E179K	DO219044	BLCA	ICGC	FFLHGD	LIG_APCC_ABBA_1	0.1111
p.N181K	DO229035	LICA	ICGC	FFLHGD	LIG_APCC_ABBA_1	0.0556
p.C162Y	DO229248	THCA	ICGC	FFLHGD	LIG_APCC_ABBA_1	0.2222
p.F166L	SIDM01343	Gastric Carcinoma	GDSC	FFLHGD	LIG_APCC_ABBA_1	0.587
p.F166L	ACH-000764	Gastric Cancer	CCLE	FFLHGD	LIG_APCC_ABBA_1	0.587

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	LIG_APCC_ABBA_1	166:171	FFLHGD	APC,CDC20,FZR1	0.571	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons