DegronMD

Uniprot ID: Q9UHV7

Source protein: Mediator of RNA polymerase II transcription subunit 13

Source gene: MED13

Class: DEG_COP1_1

Location: 1056:1065

E3 ligase: COP1

DEGRON score: 0.9832

ASA_SCORE: 83.09

COIL: 0.9567

CONS_SCORE: 0.3608

DSS_SCORE: 0.3511

HELIX: 0.0162

FCONS_SCORE: 0.8572

RIG_SCORE: 0.7162

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1068S	TCGA-BS-A0UF	UCEC	TCGA	SVEPATVPSI	DEG_COP1_1	0.25
p.A1068S	DO41488	UCEC	ICGC	SVEPATVPSI	DEG_COP1_1	0.25
p.P1059H	TCGA-CD-A4MG	STAD	TCGA	SVEPATVPSI	DEG_COP1_1	0.6583
p.P1059H	DO48009	STAD	ICGC	SVEPATVPSI	DEG_COP1_1	0.6583
p.C1051R	DO234417	ESAD	ICGC	SVEPATVPSI	DEG_COP1_1	0.1944
p.N1074K	DO233629	GACA	ICGC	SVEPATVPSI	DEG_COP1_1	0.0833
p.A1068E	DO229032	LICA	ICGC	SVEPATVPSI	DEG_COP1_1	0.25
p.H1069Q	SIDM00570	Gastric Carcinoma	GDSC	SVEPATVPSI	DEG_COP1_1	0.2222
p.H1069Q	ACH-000674	Gastric Cancer	CCLE	SVEPATVPSI	DEG_COP1_1	0.2222
p.P1063S	SIDM00853	Other Sarcomas	GDSC	SVEPATVPSI	DEG_COP1_1	0.6752
p.P1063S	ACH-000835	Sarcoma	CCLE	SVEPATVPSI	DEG_COP1_1	0.6752
p.P1063S	GCT	soft_tissue	COSMIC	SVEPATVPSI	DEG_COP1_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_COP1_1	1056:1065	SVEPATVPSI	COP1	0.9832	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons