DegronMD

Uniprot ID: Q9UHV7

Source protein: Mediator of RNA polymerase II transcription subunit 13

Source gene: MED13

Class: DEG_SCF_FBW7_1

Location: 860:867

E3 ligase: FBXW7

DEGRON score: 0.9963

ASA_SCORE: 77.0375

COIL: 0.9398

CONS_SCORE: 0.3556

DSS_SCORE: 0.57

HELIX: 0.0155

FCONS_SCORE: 0.9688

RIG_SCORE: 0.6743

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S859N	TCGA-06-5416	GBM	TCGA	MDTTPGGT	DEG_SCF_FBW7_1	0.3056
p.S859N	DO10880	GBM	ICGC	MDTTPGGT	DEG_SCF_FBW7_1	0.3056
p.S874C	TCGA-44-7670	LUAD	TCGA	MDTTPGGT	DEG_SCF_FBW7_1	0.1389
p.S874C	TCGA-AC-A23H	BRCA	TCGA	MDTTPGGT	DEG_SCF_FBW7_1	0.1389
p.S874C	DO2401	BRCA	ICGC	MDTTPGGT	DEG_SCF_FBW7_1	0.1389
p.S874C	DO23555	LUAD	ICGC	MDTTPGGT	DEG_SCF_FBW7_1	0.1389
p.M850I	TCGA-BS-A0UV	UCEC	TCGA	MDTTPGGT	DEG_SCF_FBW7_1	0.0556
p.M850I	DO42793	UCEC	ICGC	MDTTPGGT	DEG_SCF_FBW7_1	0.0556
p.E856Q	TCGA-FD-A6TA	BLCA	TCGA	MDTTPGGT	DEG_SCF_FBW7_1	0.2222
p.E856Q	DO49753	BLCA	ICGC	MDTTPGGT	DEG_SCF_FBW7_1	0.2222
p.V868F	DO229213	THCA	ICGC	MDTTPGGT	DEG_SCF_FBW7_1	0.3056
p.I876M	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	MDTTPGGT	DEG_SCF_FBW7_1	0.0833
p.I876M	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	MDTTPGGT	DEG_SCF_FBW7_1	0.0833
p.T862A	SIDM01574	Plasma Cell Myeloma	GDSC	MDTTPGGT	DEG_SCF_FBW7_1	0.6028
p.T862A	ACH-000588	Myeloma	CCLE	MDTTPGGT	DEG_SCF_FBW7_1	0.6028
p.T862K	ACH-000219	Skin Cancer	CCLE	MDTTPGGT	DEG_SCF_FBW7_1	0.6195
p.T862K	ACH-000470	Colon/Colorectal Cancer	CCLE	MDTTPGGT	DEG_SCF_FBW7_1	0.6195
p.T862K	ACH-001199	Colon/Colorectal Cancer	CCLE	MDTTPGGT	DEG_SCF_FBW7_1	0.6195

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SCF_FBW7_1	860:867	MDTTPGGT	FBXW7	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons