DegronMD

Uniprot ID: Q9UHV7

Source protein: Mediator of RNA polymerase II transcription subunit 13

Source gene: MED13

Class: DEG_SPOP_SBC_1

Location: 1521:1525

E3 ligase: SPOP

DEGRON score: 0.7322

ASA_SCORE: 74.48

COIL: 0.7608

CONS_SCORE: 0.2654

DSS_SCORE: 0.3155

HELIX: 0.1374

FCONS_SCORE: 1.0748

RIG_SCORE: 0.7803

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1524N	DO228976	LICA	ICGC	AISTS	DEG_SPOP_SBC_1	0.7055
p.A1521P	SIDM00845	Burkitt's Lymphoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.6392
p.A1521P	SIDM01519	Head and Neck Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.6392
p.V1516M	SIDM00845	Burkitt's Lymphoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.1944
p.M1514I	ACH-000901	Lung Cancer	CCLE	AISTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95721	Synaptosomal-associated protein 29	DEG_SPOP_SBC_1	149:153	AISTS	SPOP	0.6634	More...
P13073	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	DEG_SPOP_SBC_1	14:18	AISTS	SPOP	0.8718	More...
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_SPOP_SBC_1	2047:2051	AISTS	SPOP	0.9931	More...
Q92633	Lysophosphatidic acid receptor 1	DEG_SPOP_SBC_1	3:7	AISTS	SPOP	0.8246	More...
Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	DEG_SPOP_SBC_1	240:244	AISTS	SPOP	0.9994	More...
Q9H694	Protein bicaudal C homolog 1	DEG_SPOP_SBC_1	583:587	AISTS	SPOP	0.8688	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	1521:1525	AISTS	SPOP	0.7322	More...
Q9UK61	Protein TASOR	DEG_SPOP_SBC_1	857:861	AISTS	SPOP	0.8563	More...
Q53QW1	Testis-expressed protein 44	DEG_SPOP_SBC_1	61:65	AISTS	SPOP	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons